Titlebook: Antibody-Drug Conjugates and Cellular Metabolic Dynamics; Shuqing Chen,Jinbiao Zhan Book 2023 The Editor(s) (if applicable) and The Author

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Antibody-Drug Conjugates: Basic Concepts and Structures,e antigens which are expressed only on tumor cells. As one of crucial component, linkers such as cleavable linkers and noncleavable linkers have been explored. Finally, the highly effective payloads including tubulin inhibitors and DNA-damaging antibiotics have been discussed.

rectum

The Internalization and Intracellular Trafficking of ADCs,arly, the process of internalization and intracellular trafficking is thought to be crucial and need to be fully elucidated. Here, the internalization mechanism of ADC, including endocytosis pathways, intracellular processing and actions of ADC will be discussed.

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流浪

Determination of Drug-to-Antibody Ratio of ADCs,y of ADCs and their dissociation of small molecules in vivo. It is necessary to determine the DAR of ADCs. This chapter describes some methods for the DAR analysis, including reversed phase high performance liquid chromatography (RP-HPLC), hydrophobic interaction chromatography (HIC) and liquid chromatography-mass spectrometry (LC-MS).

POWER

Pharmacokinetic Study of Antibody-Drug Conjugates,f ADCs is the prerequisite for a thorough understanding the responses to ADCs. In this chapter, several technologies for analyzing the pharmacokinetic properties of ADCs are described, and a novel strategy is proposed by integrating the advantages of some technologies to evaluate metabolism of ADCs more accurately.

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Forschungsgruppe Konsum und Verhaltenects. A new type of entigen should be digged and developed for future antibody-based therapies. In this chapter, we discuss tumor-associated antigen, tumor-specific antigens on cell membrane, and several mutant peptides MHC I for de novo antibody-based drug antigen research.

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Mitbestimmungsrecht des Betriebsratespharmacokinetic process of ADCs when these molecules are administered into blood system. At last, we introduced some commonly used detection methods that enable researchers to trace the metabolites after metabolization happening.

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Distribution and Metabolism of Antibody-Drug Conjugates,pharmacokinetic process of ADCs when these molecules are administered into blood system. At last, we introduced some commonly used detection methods that enable researchers to trace the metabolites after metabolization happening.