Titlebook: Antibody Methods and Protocols; Gabriele Proetzel,Hilmar Ebersbach Book 2012 Springer Science+Business Media, LLC 2012 Antibodies.Antibody

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Generation of Human Fab Libraries for Phage Display,s for their subsequent selection by phage display. Although it can be applied to the mining of both human na?ve and immune antibody repertoires, the procedure is primarily intended for the generation of fully human monoclonal antibodies from patients with endogenous antibody responses of interest and limited availability of clinical specimens.

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The Application of Transgenic Mice for Therapeutic Antibody Discovery,ion (FDA). Since then, a further seven such antibodies have been approved. In this chapter, we discuss how transgenic mice technologies can provide a powerful platform for creating human therapeutic antibodies.

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