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Titlebook: Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II); Thiol “Switch-on” Fl Taotao Zou Book 2016 Springer Sci

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發(fā)表于 2025-3-21 19:35:27 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
期刊全稱Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II)
期刊簡(jiǎn)稱Thiol “Switch-on” Fl
影響因子2023Taotao Zou
視頻videohttp://file.papertrans.cn/159/158320/158320.mp4
發(fā)行地址by The University of Hong Kong as an outstanding Ph.D. thesis.reviews the current status of gold- and platinum-based anti-cancer agents.Highlightsthe significant advances made in the area of metal-bas
學(xué)科分類(lèi)Springer Theses
圖書(shū)封面Titlebook: Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II); Thiol “Switch-on” Fl Taotao Zou Book 2016 Springer Sci
影響因子.This thesis focuses on the development of gold- and non-classical platinum-based anti-cancer agents that display distinctively different anti-cancer mechanisms compared to the commonly used cisplatin. These metal complexes contain N-heterocyclic carbene (NHC) ligands which are able to form strong M-C(NHC) bonds, conferring high stability and favorable lipophilicity, reactivity and binding specificity of metal complexes on biomolecules. The author demonstrates significant advances made in anti-cancer gold(III), gold(I) and platinum(II) complexes. Detailed chemical synthesis, in vitro and/or in vivo anti-cancer activities are clearly presented including: (i) a class of Au(III) complexes containing a highly fluorescent N^N^N ligand and NHC ligand that simultaneously act as fluorescent thiol “switch-on” probes and anti-cancer agents; (ii) a dinuclear gold(I) complex with a mixed diphosphine and bis(NHC) ligand displaying favorable stability and showing significant inhibition of tumor growth in two independent mice models with no observable side effects; and (iii) a panel of stable luminescent cyclometalated platinum(II) complexes exhibiting high specificity to localize to the endoplas
Pindex Book 2016
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書(shū)目名稱Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II)影響因子(影響力)




書(shū)目名稱Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II)影響因子(影響力)學(xué)科排名




書(shū)目名稱Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II)網(wǎng)絡(luò)公開(kāi)度




書(shū)目名稱Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II)網(wǎng)絡(luò)公開(kāi)度學(xué)科排名




書(shū)目名稱Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II)被引頻次




書(shū)目名稱Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II)被引頻次學(xué)科排名




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發(fā)表于 2025-3-22 00:12:36 | 只看該作者
Experimental Section,bardment (FAB) mass spectra were acquired on a Finnigan Mat 95 mass spectrometer. Electrospray ionization (ESI) mass spectrometry experiments were performed on a Waters Micromass Q-Tof Premier quadrupole time-of-flight tandem mass spectrometer or on an LTQ Orbitrap Velos mass spectrometer (Thermo Sc
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發(fā)表于 2025-3-22 08:48:06 | 只看該作者
Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II)978-981-10-0657-9Series ISSN 2190-5053 Series E-ISSN 2190-5061
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發(fā)表于 2025-3-22 14:52:38 | 只看該作者
https://doi.org/10.1007/978-3-540-34030-0bardment (FAB) mass spectra were acquired on a Finnigan Mat 95 mass spectrometer. Electrospray ionization (ESI) mass spectrometry experiments were performed on a Waters Micromass Q-Tof Premier quadrupole time-of-flight tandem mass spectrometer or on an LTQ Orbitrap Velos mass spectrometer (Thermo Scientific).
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發(fā)表于 2025-3-23 07:24:40 | 只看該作者
Frequenzverhalten analoger Schaltungen,Stimulated by the success of cisplatin to combat cancers, numerous research interests have been aroused to the development of new metal-based antitumor therapeutics [.–.].
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