Titlebook: Anoikis; How the Extracellula Steven M. Frisch Book 2021 Springer Nature Switzerland AG 2021 Anoikis.Apoptosis.Cancer.Epithelial-Mesenchyma

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https://doi.org/10.1007/978-3-8349-8069-4lular matrix induces cellular stressors, including nutrient-deprivation and oxidative stress, and this elevated cellular stress leads to apoptosis. In contrast, cancer cells often have an increased capacity to adapt to cellular stressors, and these adaptations include metabolic reprogramming to acco

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https://doi.org/10.1007/978-3-8349-8069-4ween proliferation and the newly characterized biologic process called cell extrusion. Cell extrusion ejects live cells from overcrowded epithelia, where these cells may or may not die by anoikis, depending on their genome and microenvironment. Their failure to undergo anoikis may promote tumor meta

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Metabolic Reprogramming and the Control of Anoikis Resistance in Cancer,M) attachment [., .]. Cancer cells, on the other hand, can circumvent this process which enables them to survive matrix-deprivation, disseminate through blood or lymphatics, and attach to distant organs with different matrix compositions [.]. Part of their ability to do so is linked to the metabolic