Titlebook: Annual Update in Intensive Care and Emergency Medicine 2021; Jean-Louis Vincent Book 2021 The Editor(s) (if applicable) and The Author(s),

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https://doi.org/10.1007/978-88-470-0609-6ARDS) seem to have considerable heterogeneity. Pathogenesis is driven by monocytes, levels of which are increased in the blood and which migrate from the circulation to the alveolar space to propagate pro-inflammatory phenomena. At the stage of severe illness, the nucleotide-binding domain-like rece

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https://doi.org/10.1007/978-88-470-0609-6rs, there has been increasing interest in the effects of intravenous vitamin C in critically ill patients, but results of multiple clinical trials are not consistent. A possible explanation is the heterogeneity in study designs and included patients. Patients with vitamin C deficiency may benefit mo

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12 Bezüge zu Irrungen, Wirrungenpt recognition and treatment to provide adequate oxygen utilization to the cells. Initial characterization of sepsis-associated cardiovascular dysfunction was based on clinical patterns identified by physical examination; however, the use of invasive and, more recently, non-invasive tools for hemody

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12 Bezüge zu Irrungen, Wirrungenicient to achieve this goal. Current guidelines recommend norepinephrine as the first-choice vasopressor in this context; however, some conditions, such as refractory septic shock, may require high doses of norepinephrine, which may be associated with various adverse effects and increased mortality

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