Titlebook: Annual Update in Intensive Care and Emergency Medicine 2016; Jean-Louis Vincent Book 2016 Springer International Publishing Switzerland 20

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Myths and Facts Regarding Lactate in Sepsisis more a “habit of mind” then a real phenomenon and has limited clinical relevance [4]. We will argue that lactate is a crucial molecule in energy metabolism, acid base homeostasis and cellular signaling in sepsis largely independent of tissue oxygenation.

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2191-5709 y medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine..978-3-319-27348-8978-3-319-27349-5Series ISSN 2191-5709 Series E-ISSN 2191-5717

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https://doi.org/10.1007/978-3-8349-9891-0here are positive studies [3, 4] showing that PCT-guided patient management reduced antibiotic exposure and length of antibiotic therapy without affecting patient outcomes. There are also negative studies, which did not show this benefit [5–7]. However, to understand the values and limitations of in

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,Einkünfte aus nichtselbst?ndiger Arbeit,election pressure and potential harm to future patients or to the same patient in the future, whereas withholding antibiotics will avoid selection pressure but may put the individual patient at increased risk of harm caused by an untreated infection. This dilemma is made worse by the fact that, in c

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