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Titlebook: Animal Models of T Cell-Mediated Skin Diseases; T. Zollner,H. Renz,K. Asadullah Conference proceedings 2005 Springer-Verlag Berlin Heidelb

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發(fā)表于 2025-3-21 17:29:16 | 只看該作者 |倒序瀏覽 |閱讀模式
期刊全稱Animal Models of T Cell-Mediated Skin Diseases
影響因子2023T. Zollner,H. Renz,K. Asadullah
視頻videohttp://file.papertrans.cn/158/157659/157659.mp4
學(xué)科分類Ernst Schering Foundation Symposium Proceedings
圖書封面Titlebook: Animal Models of T Cell-Mediated Skin Diseases;  T. Zollner,H. Renz,K. Asadullah Conference proceedings 2005 Springer-Verlag Berlin Heidelb
影響因子.Pharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless, attrition rates in clinical development are still very high, and up to 90% of new compounds fail in clinical phase I - III trials, which is partially due to lack of clinical efficacy. This indicates a strong need for highly predictive in vitro and in vivo models. The "50th International Workshop of the Ernst Schering Research Foundation" focussed on "Animal Models of T Cell-Mediated Skin Diseases". Such animal models should have impact not only on inflammatory dermatoses but also on other inflammatory disorders due to their model character. The current volume summarises recent advances in animal research that are important for anti-inflammatory drug discovery..
Pindex Conference proceedings 2005
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T-Cell Receptor Transgenic Models of Inflammatory Disorders: Relevance for Atopic Dermatitis?,
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What Must a Model Display for Proof as a Model of Psoriasis?,
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Making Gene-Modified Mice,ly play a central role in biomedical research in the years to come, hopefully leading to the better understanding of pathogenic mechanisms and to new, more effective therapeutic approaches to human disease.
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Murine Models of Atopic Dermatitis,ifferent approaches increase the size and versatility of the toolkit available, as shown by deletion of genes in NC/Nga mice, thus allowing even deeper insights in the mechanism of AD. Mice with a spontaneous AD phenotype are also suitable for drug testing and development. This also applies to the c
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