Titlebook: Angiotensin II Receptor Blockade Physiological and Clinical Implications; Naranjan S. Dhalla (Distinguished Professor and Di Book 1998 Spr

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EU Digital Copyright Law and the End-User in the vascular and cardiac remodeling observed in response to chronic or acute hypertension. Two major Ang II receptor subtypes, AT. and AT., have been described, and their roles in vivo and in vitro have now been investigated using nonpeptidic antagonists, losartan and PD123319, which block AT. a

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EU Digital Copyright Law and the End-Userve heart failure. The development of losartan, a biphenyltetrazole derivative, was based on a carefully managed, rational drug design aimed at improving the low-oral bioavailability normally observed with peptide antagonists. The drug was also designed to preserve selectivity at the AT. receptor sit

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EU Digital Copyright Law and the End-Userssault was further amplified by the introduction, in Canada, of the first angiotensin receptor antagonist, an agent that appeared to be devoid of activities involving bradykinin. Intriguingly, this assault was also fueled by some pharmaceutical companies who had ACE inhibitors, but no angiotensin re

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Angiotensin II Receptor Blockade Physiological and Clinical Implications978-1-4615-5743-2Series ISSN 1389-1774

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https://doi.org/10.1007/978-1-4615-5743-2Angiotensin II; blood pressure; cardiovascular; heart; hypertension