Titlebook: Analysis of Genetic Association Studies; Gang Zheng,Yaning Yang,Robert C. Elston Book 2012 Springer Science+Business Media, LLC 2012 Assoc

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書目名稱Analysis of Genetic Association Studies影響因子(影響力)




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Bayes Factors for Case-Control Association Studieslikelihood estimate of the odds ratio for the genetic effect. In this chapter, the underlying genetic model is assumed to be known (either a recessive, additive or dominant model). How to code the genetic effect in a Bayesian analysis is discussed. The result may depend on how the genetic effect is

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Haplotype Analysis for Case-Control Dataotype frequencies. Haplotype disequilibrium, testing for linkage disequilibrium (LD), haplotype blocks and tagging SNPs are discussed. Two types of tests are considered. The first is haplotype-based association analysis, including the likelihood ratio test, regression method, and haplotype similarit

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Gene-Gene Interactions The expressions of odds ratios for the main genetic effects and the gene-gene interaction are given. A saturated logistic regression model is also studied. Different test statistics for the two-locus interaction model are discussed. Their relation to contrasting log-odds ratios and contrasting LD m

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Gene-Environment Interactionsnvironmental factor effect, and the gene-environment interaction are given. More general cases for gene and environmental factors are briefly discussed. Three common tests for gene-environment interaction are studied, including the Score test, the likelihood ratio test (LRT) and the Wald test. Examp