期刊全稱 | Analgesia | 影響因子2023 | Christoph Stein | 視頻video | http://file.papertrans.cn/156/155791/155791.mp4 | 發(fā)行地址 | Includes supplementary material: | 學(xué)科分類 | Handbook of Experimental Pharmacology | 圖書封面 |  | 影響因子 | Analgesics are among the oldest drugs described, albeit not necessarily for medicinaluse. Forexample,theSumeriansisolatedopioids(probablyfortheir euphoric effects) in the third millennium b. c. and the use of willow bark (salicin) for fever was ?rst reported in the eighteenth century. Both types of drugs are still in use, but today they are supplemented by a wide array of substances ranging from antidepressants to ion channel blockers. Not all of theseareprescribedbyphysicians. Manycompoundsaresoldoverthecounter and thus available to the public for self-medication. As a result, analgesics are also the most misused class of drugs and are the culprit for a multitude of healthproblemsdueto untoward sideeffects. Thisvolumeattemptstosummarizethecurrentstateofknowledgeonme- anisms underlying the various effects of these drugs, their side effect pro?les, and their indications and contraindications in clinical use. It also gives - sights into current efforts to discover novel mechanisms underlying different types of pain generation and the resulting development of new modulating compounds. Theseefforts haveemergedmostlyas aconsequenceofthemore profound insights provided by molecular method | Pindex | Book 2007 |
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