Titlebook: Anal Cancer; A Comprehensive Guid Jeffrey Meyer,Lisa Kachnic Book 2019 Springer Nature Switzerland AG 2019 anal cancer.lower gastrointestin

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Anatomy and Histology of the Anus,versimplified, but the alternative perspectives on this anatomic region and its histologic characteristics influence how anal cancer pathology is conceptualized and ultimately treated. In this chapter, we highlight the divergent definitions and complexity of anal canal anatomy, review the anatomic a

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Staging and Initial Evaluation of Anal Cancer, to a delay in diagnosis. As the treatment of anal cancer is nonsurgical, anal cancer is clinically staged with an emphasis on physical examination, focusing on digital rectal exam (DRE), inguinofemoral lymph node evaluation, and gynecologic exam in female patients. Anoscopy or proctoscopy with biop

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Anal Cancer: Toxicities and Management,to be highly effective in this disease; however, it is associated with acute and late toxicities. Toxicities associated with the standard chemotherapy agents (5-fluorouracil [5-FU] and mitomycin C) include diarrhea, nausea, stomatitis, mucositis, hand-foot syndrome, and myelosuppression. Acute toxic

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Management of Local-Regional Anal Cancer Recurrence,ents experience local relapse, and salvage surgery is a second line of treatment for these patients. Wide local excision, abdominoperineal resection, pelvic exenteration with or without sacrectomy, and inguinal node dissection are all surgical options. In this chapter, we review the management and t

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Treatment of Non-squamous Histologies in Anal Cancer,arge-cell neuroendocrine tumors, classic small-cell carcinoma, and adenocarcinoma. Each of these tumors has a unique natural history and distinct response to therapy. So while the treatment approach requires familiar combinations of surgical, systemic, and radiation therapy techniques, this chapter

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Diagnosis and Management of Perianal Skin Tumors,re rare and frequently misdiagnosed. Those covered in this chapter include Paget’s disease, basal cell cancer, and rhabdomyosarcoma in the pediatric population. Workup of these perianal lesions is similar, consisting of histologic tissue diagnosis followed by clinical and radiographic staging evalua