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Titlebook: Amine Oxidases and Their Impact on Neurobiology; Proceedings of the 4 Peter Riederer,Moussa B. H. Youdim Conference proceedings 1990 Spring

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31#
發(fā)表于 2025-3-26 23:19:40 | 只看該作者
Molecular neuroanatomy of MAO-A and MAO-Band abundance of MAO-A and MAO-B in the central nervous system and peripheral organs in the rat. The in vitro approach was also used to map the enzymes in human post-mortem brain. Furthermore, using in situ hybridization histochemistry, locus coeruleus and raphé neurons in the human brain were found
32#
發(fā)表于 2025-3-27 04:47:53 | 只看該作者
Turnover of monoamine oxidase B (MAO-B) in pig brain by positron emission tomography using 11C-L-depirreversible ligand, which bind stoichiometrically to the enzyme. A tracer dose of. C-L-deprenyl was injected and PET scans performed to obtain baseline deprenyl binding. A high dose of unlabelled deprenyl was then administered to inhibit the enzyme and tracer doses of . C-L-deprenyl, with subsequen
33#
發(fā)表于 2025-3-27 08:42:49 | 只看該作者
34#
發(fā)表于 2025-3-27 12:26:25 | 只看該作者
35#
發(fā)表于 2025-3-27 14:29:47 | 只看該作者
Some pharmacological implications of MAO-mediated deamination of branched aliphatic amines: 2-Propylbazide-sensitive amine oxidase. The deaminated product, valproic acid (VPA), was identified by HPLC-fluorometric assessment. Absorption and biotransformation of these compounds and their VPA metabolite into the brain were rapid processes. An investigation was conducted to examine whether these compo
36#
發(fā)表于 2025-3-27 21:29:35 | 只看該作者
37#
發(fā)表于 2025-3-28 00:23:04 | 只看該作者
38#
發(fā)表于 2025-3-28 05:22:32 | 只看該作者
Ring-substituted analogues of tranylcypromine as monoamine oxidase inhibitorstested for their ability to inhibit, relative to tranylcypromine, monoamine oxidase (MAO) -A and -B in rat brain after administration of low doses (1.2 and 3.7 μmol/kg) of the drugs. One hour after intraperitoneal injection of the lower dose, tranylcypromine was weaker than 4-fluorotranylcypromine a
39#
發(fā)表于 2025-3-28 09:02:41 | 只看該作者
40#
發(fā)表于 2025-3-28 10:43:56 | 只看該作者
Stylbasole analogues of MPTP as monoamine oxidase (MAO) substrates compounds was shown to be catalyzed by both serotonine specifical and benzylamine specifical MAO activities. Markedly high affinity of stylbasoles to B type of MAO was found. Influence of substrate structure on its biotransformation effectiveness is realized by the principle — “better binding-worse
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