Titlebook: Alzheimer’s Disease Research; What Has Guided Rese Christian Behl Book 2023 The Editor(s) (if applicable) and The Author(s), under exclusiv

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Getting to the Bottom of It: Amyloid Beta Peptide Is Derived from a Larger Precursor,y?of amyloid beta research. For instance, a link of herpes simplex virus to Alzheimer’s disease was described and a role of nerve cell survival factors (neurotrophic factors) in its pathogenesis was proposed. However, all these additional findings were largely overshadowed by the excitement over amy

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,Step by Step Toward an Amyloid Beta Peptide-Based Hypothesis of Alzheimer’s Disease,on approach targeting amyloid can retrospectively be defined as the hot phase in Alzheimer’s research. Most strikingly, human genetics delivered evidence that mutations in the . gene are linked to dominantly inherited familial forms of the disease. Subsequently, two more genes were identified as Alz

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Concerns about the , and Reappraisals, a pathogenetic role, the . has?remained the most influential and field-guiding hypothesis in Alzheimer’s disease research..Even?more than three decades after its introduction, this hypothesis still?asserts its dominance, and amyloid persists as the prime target in the search for a . therapy; clinic