| 期刊全稱 | Alternative Splicing and Disease | | 影響因子2023 | Philippe Jeanteur | | 視頻video | http://file.papertrans.cn/155/154119/154119.mp4 | | 發(fā)行地址 | First book to highlight the medical implications, i.e. diseases, caused by alternative splicing.Outlines possible targets for therapy.Written by internationally reknown experts.Includes supplementary | | 學科分類 | Progress in Molecular and Subcellular Biology | | 圖書封面 |  | | 影響因子 | .Splicing of primary RNA transcript, i.e. removal of introns and joining of exons to produce mature mRNAs competent for translation into proteins, is a quasi-systematic step of gene expression in higher organisms. However, this process is not unequivocal but can follow alternate pathways. Alternative splicing of a given transcript can therefore yield several distinct mRNAs encoding as many different proteins. Its full biological significance has not been appreciated until it was recognized that alternative splicing is so general as to affect about 75% of all human genes. Therefore, alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences.. | | Pindex | Book 2006 |
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