Titlebook: Alternating Electric Fields Therapy in Oncology; A Practical Guide to Eric T. Wong Book 2016 Springer International Publishing Switzerland

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Fundamental Physics of Tumor Treating Fields,. Recently, the anticancer Tumor Treating Fields (TTFields), which are alternating electric fields applied according to the principles of Maxwell’s equations of electromagnetism, has made available a novel method of treating patients with glioblastomas, brain metastases, and certain systemic maligna

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Biophysical Effects of Tumor Treating Fields, theoretical investigations lead to numerous cell characterization and manipulation techniques which were translated into clinical applications. Low-frequency alternating current (AC) fields are employed for nerve and muscle stimulation, while high-frequency fields find medical relevance in tissue h

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Computer Simulation of Tumor Treating Fields,ents. TTFields are alternating electric fields at 200 kHz continuously delivered by the Optune device to the scalp of patients. Preclinical experiments have shown that they interfere with dividing cancer cells as they undergo metaphase-to-anaphase transition in mitosis and, specifically, they disrup

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Response Pattern and Modeling of Tumor Treating Fields,. The Optune device represents an innovative treatment option for patients with recurrent GBM, which utilizes alternating electric fields at an intermediate frequency of 200 kHz, or Tumor Treating Fields (TTFields), to selectively kill or arrest the growth of rapidly dividing cells. Approximately 15

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Clinical Efficacy of Tumor Treating Fields for Recurrent Glioblastoma, criteria but the extent of the tumor is much larger than that can be seen on neuroimaging. Patient prognosis is poor and survival is short. The Optune device is an FDA-approved treatment for recurrent glioblastoma and it uses Tumor Treating Fields (TTFields) to disrupt tumor cells as they undergo m

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Tumor Treating Fields Therapy for Newly Diagnosed Glioblastoma, within the tumor microenvironment. These inter-tumoral and intra-tumoral heterogeneities are what make glioblastomas so difficult to treat in patients. As the tumor progresses over time, it accumulates more alterations and co-opts normal physiological processes for growth and proliferation as well

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Future Directions for Tumor Treating Fields,d glioblastoma since receiving FDA approvals in 2011 and 2015, respectively. Where this treatment modality goes from here is currently a subject of intensive clinical investigations. For glioblastoma, TTFields are being combined with stereotactic radiosurgery, hypofractionated radiation, bevacizumab