Titlebook: Algorithms in Bioinformatics; 15th International W Mihai Pop,Hélène Touzet Conference proceedings 2015 Springer-Verlag Berlin Heidelberg 20

詞匯記憶方法

Association Mapping for Compound Heterozygous Traits Using Phenotypic Distance and Integer Programm to be caused by genetics. The most common explanation for this is the presence of multiple rare mutations that cannot be identified in GWAS due to a lack of statistical power. Such rare mutations may be concentrated in relatively few genes, as is the case for many known Mendelian diseases, where th

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Semi-nonparametric Modeling of Topological Domain Formation from Epigenetic Data, of the 3D genome organization and appear to play a role in gene regulation and other functions. Several histone modifications have been independently suggested as the possible explanations of TAD formation, but their combinatorial effects on domain formation remain poorly understood at a global sca

縮影

Scrible: Ultra-Accurate Error-Correction of Pooled Sequenced Reads,f DNA barcoding when multiplexing a large number of samples on second-generation sequencing instruments. Here we address the problem of correcting the short reads obtained from our sequencing protocol. We introduce a novel algorithm called . that exploits properties of the pooling design to accurate

Merited

MAZE

Range-Of-Motion

Circular Sequence Comparison with ,-grams,mparison are based on the notions of distance or similarity, and are generally computed through sequence alignment techniques. As . genome structure is a common phenomenon in nature, a caveat of specialized alignment techniques for circular sequence comparison is that they are computationally expens

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邊緣帶來墨水

A Filtering Approach for Alignment-Free Biosequences Comparison with Mismatches,n fact, in several contexts, with respect to alignment-based approaches, alignment-free techniques are faster but less accurate. Recently, several studies (e.g. [., ., .]) attempted to bridge the accuracy gap with the introduction of approximate matches in the definition of composition-based distanc

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Models and Algorithms for Genome Rearrangement with Positional Constraints, same number of rearrangements are considered equally good. In this paper, we acknowledge that each rearrangement has a certain likelihood of occurring based on biological constraints, . physical proximity of the DNA segments implicated, or repetitive sequences. Accordingly, we propose optimization

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Sparse RNA Folding Revisited: Space-Efficient Minimum Free Energy Prediction,eractions. Sparsification has been successfully applied to improve the time efficiency of various structure prediction algorithms while guaranteeing the same result; however, for many such folding problems, space efficiency is of even greater concern, in particular for long RNAs and complex folding