| 期刊全稱 | Airways Smooth Muscle: Development, and Regulation of Contractility | | 期刊簡稱 | Development and Regu | | 影響因子2023 | David Raeburn (Department Head),Mark A. Giembycz ( | | 視頻video | http://file.papertrans.cn/152/151897/151897.mp4 | | 學科分類 | Respiratory Pharmacology and Pharmacotherapy | | 圖書封面 |  | | 影響因子 | Most studies on autonomic innervation of smooth muscle have focused on the short-term mechanisms involved in neurotransmission in physiological and pathophysiological conditions. However recent obser- vations of the long-term plasticity of this system, i. e. its capacity for regeneration and for compensatory change in pattern of innervation and expression of cotransmitters and receptors in ageing, following surgery, trauma or in disease, have indicated that an understanding of the mechanisms involved could influence the design of therapeutic regimes. There is increasing evidence for long-term communication between nerves and smooth muscle cells during development and throughout adult life. To date, the trophic interactions between nerves and airway musculature have attracted little interest, consequently, much of the information presented here is drawn from studies using other smooth muscles. However, the questions posed about trophic interactions dur- ing development apply as much to airways smooth muscle neuroeffector systems as to other autonomic neuroeffector systems. These are: i) How do developing nerve fibres know where to go and how do they reach their target sites? ii) Wha | | Pindex | Book 1994 |
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