Titlebook: Aging Research in Yeast; Michael Breitenbach,S. Michal Jazwinski,Peter Laun Book 2012 Springer Science+Business Media B.V. 2012 Aging.Cell

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Oxidative Stresses and Ageing,hemistry has provided the opportunity to analyse in some detail how reactive oxygen and nitrogen species arise in cells, how cells respond to the damage that these reactive species cause, and to begin to dissect how these species may be involved in the ageing process. This chapter reviews the major

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Chronological Aging in , ,e of the mean and maximum survival time of non-dividing yeast populations while the replicative life span is based on the mean and maximum number of daughter cells generated by an individual mother cell before cell division stops irreversibly. Here we review the principal discoveries associated with

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Aging and the Survival of Quiescent and Non-quiescent Cells in Yeast Stationary-Phase Cultures, aging studies and hold much promise in pinpointing the set of causal genes and mechanisms driving aging. Importantly, a more detailed understanding of aging in this single celled organism will also shed light on aging in tissue-complex model organisms such as . and . We feel strongly that the relat

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DNA Damage and DNA Replication Stress in Yeast Models of Aging,complex organisms, only a relatively few studies have investigated DNA damage as an aging factor in the model organism .. Several of these studies point to DNA replication stress as a cause of age-dependent DNA damage in the replicative model of aging, which measures how many times budding yeast cel

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Yeast Aging and Apoptosis,s a destructive process leading to the death of single cells, also serves as a pro-survival mechanism that ensures healthy organismal development and acts as a life-prolonging or anti-aging program. The discovery that yeast also possess a functional and, in many cases, highly conserved apoptotic mac

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Cellular Homeostasis in Fungi: Impact on the Aging Process,re usually highly detrimental. Functional impairments of cell components can lead to diseases and in extreme cases to organismal death. Dysfunction of cells can be induced by a number of toxic by-products that are formed during metabolic activity, like reactive oxygen and nitrogen species, for examp

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