Titlebook: Advances in Tumor Immunology and Immunotherapy; Joseph D. Rosenblatt,Eckhard R. Podack,Augusto Och Book 2014 Springer Science+Business Med

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The Immune System in Head and Neck Squamous Cell Carcinoma: Interactions and Therapeutic Opportunitiparent that efforts to stimulate a therapeutically effective immune response against established tumors must be coupled with strategies to abrogate this immune-suppressive environment. Preclinical studies and clinical trials have yielded promising results and provide the foundation for further refin

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T Cell Co-regulatory Signals and Their Role in Cancer Therapypression of CTLA4 or PD-1 ligands. Thus manipulation of co-regulatory signals can be used as a strategy by which to strengthen the immune response, via augmentation of T cell co-stimulation and/or blockade of inhibitory signals, in order to effectively treat cancer. In this chapter we review the bas

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2199-2584 these strategies have already been realized in the clinic. The volume will explore evolving paradigms in antigen presentation, dendritic cell biology, the innate response and immunosuppressive mechanisms, and 978-1-4939-5097-3978-1-4614-8809-5Series ISSN 2199-2584 Series E-ISSN 2199-2592

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https://doi.org/10.1057/9780230289802 cells and cytokines, which not only inhibit the host’s antitumor immune response, but also hinder the clinical efficacy of immune-based therapies. Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous collection of immature myeloid cells that play an important role in cancer immune eva