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Titlebook: Advances in Research on Neurodegeneration; Volume 10 R. Horowski,Y. Mizuno,M. B. H. Youdim Conference proceedings 2003 Springer-Verlag Wien

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發(fā)表于 2025-3-23 11:40:42 | 只看該作者
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Self-tolerance in the immune privileged CNS: lessons from the entorhinal cortex lesion model,lls (APCs). Restimulation of invading T cells by such immature APCs (e.g. CD80 negative microglia) may lead to T cell anergy and/or differentiation of regulatory/Th3-like cells due to insufficient costimulation and presence of high levels of TGF-β and IL-10 in the CNS. Thus, T cell -apoptosis, -aner
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General aspects of neurodegeneration,ses. These mechanisms that are usually interrelated in complex vitious circles finally leading to programmed cell death cascades are briefly discussed with reference to their pathogenetic role in many, albeit diverse neurodegenerative diseases, like Alzheimer disease, synucleino-pathies, tauopathies
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,Arguments for the use of dopamine receptor agonists in clinical and preclinical Parkinson’s diseasebenefit late in the therapy of the disorder. In addition, the pharmacological profile of dopamine receptor agonists suggests a possible neuroprotective effect. This paper reviews briefly the pharmacology of dopamine receptor agonists and basic knowledge concerning the dopamine receptor stimulation w
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