| 期刊全稱 | Advances in Rapid Sex-Steroid Action | | 期刊簡稱 | New Challenges and N | | 影響因子2023 | Gabriella Castoria,Antimo Migliaccio | | 視頻video | http://file.papertrans.cn/150/149543/149543.mp4 | | 發(fā)行地址 | This volume provides an up-to-date review of recently discovered rapid action of sex steroid hormones.Recent years have seen the discovery of significant numbers of master proteins in breast and prost | | 圖書封面 |  | | 影響因子 | Breast and prostate cancers are both hormone-dependent, at least in some stages of their progression. Hormonal manipulation represents an important therapeutic approach. Although most of breast and prostate cancers initially respond to hormone therapy, most tumors reinitiate to growth. Finally, hormone-resistant and metastatic breast and prostate cancers may develop. Thus, the challenge is the dissection of mechanisms by which steroid receptor signaling pathways continue to influence cell growth and invasiveness. Compelling evidence indicates that steroid hormones elicit non-genomic responses in extra-nuclear compartment of target cells. In this cellular location, steroid-coupled receptors rapidly recruit signaling effectors or scaffold proteins and activate multiple pathways leading to proliferation, survival, migration and invasiveness. The immediate challenge is the dissection of key events regulating the steroid response of target tissues to prevent progression and improve treatment of breast and prostate cancers. | | Pindex | Book 2012 |
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