| 期刊全稱 | Advances in Host-Directed Therapies Against Tuberculosis | | 影響因子2023 | Petros C. Karakousis,Richard Hafner,Maria Laura Ge | | 視頻video | http://file.papertrans.cn/149/148196/148196.mp4 | | 發(fā)行地址 | Host-directed therapy is a unique, innovative, and burgeoning new approach for the treatment of infectious diseases, and specifically for tuberculosis, the leading cause of death by a single infectiou | | 圖書封面 |  | | 影響因子 | This book discusses specific immune cell regulatory? pathway(s), immune cell types,? or other mechanisms involved in host responses to tuberculosis that can be potentially targeted for host-directed therapy (HDT). The pathways/mechanisms investigated are either protective – thus calling for pathway/factor enhancing drugs – or maladaptive – thus calling for pathway/factor inhibitory drugs. Discovery and development (pre-clinical and clinical) of candidate HDT agents will also be elucidated, as well as approaches for HDT of other diseases. The benefit to the reader will derive from learning about the biology of multiple host pathways involved in health and disease, how these pathways are disrupted or dysregulated during tuberculosis, and which druggable targets exist in these pathways. This book provides the reader with a roadmap of current and future directions of HDT against tuberculosis. Since the host pathways/factors involved in protective or maladaptive responses to tuberculosis are not disease-specific, information learned from the context of tuberculosis likely will be relevant to other infectious and non-infectious diseases.. | | Pindex | Book 2021 |
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