Titlebook: Advances in DNA Damage and Repair; Oxygen Radical Effec Miral Dizdaroglu,Ali Esat Karakaya Book 1999 Springer Science+Business Media New Yo

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Rethinking International Development series lyase activity similar to that observed for the human homologue of S3. Subsequent tests using a heavily UV-irradiated 5′ end-labeled oligonucleotide suggested that dS3 was acting on a guanine photoproduct that was determined to be 2,6-diamino-4-hydroxγ-5-formamidopyrimidine. The dS3 protein was als

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https://doi.org/10.1057/9781137505699ed out in vitro transcription experiments with phage RNA polymerases and E. coli RNA polymerase. The DNA damages investigated are representative of several major classes of base modifications and include uracil (cytosine deamination product), dihydrouracil (pyrimidine ring saturation product), abasi

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Problemstellung und Abgrenzung des Themas,such as Superoxide (O..) and hydrogen peroxide (H.O.). Patients with long-standing ulcerative colitis are also known to be at increased risk of developing colorectal cancer. Although NO and reactive oxygen intermediates have been shown to modify DNA bases and to promote a wide array of mutagenic rea

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https://doi.org/10.1007/978-3-319-59846-8tes. Fpg and Oggl catalyze excision of 8-oxoguanine paired with dC in duplex DNA while MutY is an adenine DNA glycosylase that acts preferentially on 8-oxodG:dA mispairs. By establishing structure-function relationships for these DNA repair enzymes, functional groups required for substrate recogniti

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On the Role of Cash in East Asia,free controls, ii 304 study subjects including 57 arsenical cancer patients and 247 noncancerous controls in Taiwan and iii 41 breast cancer patients and 73 controls. The host reactivation assay was used to measure cellular DRC capacity with cryopreserved peripheral lymphocytes from both the cases a

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The Use of Cash in Europe and East Asiahought that only lesions removed by nucleotide excision repair (NER) were subject to this pathway of transcription-coupled repair (TCR), but recent investigations have shown that some lesions caused by reactive oxygen species, that are recognized by glycosylases and are subject to base excision repa

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https://doi.org/10.1007/978-3-319-59846-8g of activation of oxygen species and mediation of their attack on DNA, and indirect effects through suppression of cellular antimutagenic defenses, are discussed. The mechanisms of the direct attack may involve chelation of a metal by nuclear proteins, especially the histones and protamines, and ac