Titlebook: Activating and Inhibitory Immunoglobulin-like Receptors; Max D. Cooper,Toshiyuki Takai,Jeffrey V. Ravetch Conference proceedings 2001 Spri

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書目名稱Activating and Inhibitory Immunoglobulin-like Receptors影響因子(影響力)




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書目名稱Activating and Inhibitory Immunoglobulin-like Receptors被引頻次




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cent years. These receptors have attracted widespread interest because they resemble the TCR, BCR, and FcR complexes in their ability to serve as activating or inhibitory receptors on the cells that bear them. Moreover, they are well positioned to affect both innate and adaptive immunity. The full r

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https://doi.org/10.1007/978-981-97-2724-7long to an ancient ancestral lineage of related Ig-like receptor families. A phylogenetic analysis, employing primary amino acid sequences and three-dimensional protein structures of the PIR homologs and their relatives, suggests a common ancestry for the PIR and Fc receptor families.

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https://doi.org/10.1007/978-3-030-50228-7lasmic tail and a charged amino acid in its transmembrane region, which is characteristic of an activatory receptor. Additionally, the translation starts at a different codon, if compared to other family members.

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https://doi.org/10.1007/978-3-030-50228-7y, gp49 molecules are also upregulated in the context of murine cytomegalovirus infection. Furthermore, the gp49 molecules do not appear to display allelic polymorphism, suggesting a unique functional role for gp49 molecules in regulating NK cells long after initial stimuli.

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