| 期刊全稱 | Accelerated Path to Cures | | 影響因子2023 | Josep Bassaganya-Riera | | 視頻video | http://file.papertrans.cn/144/143626/143626.mp4 | | 發(fā)行地址 | Details the role of modeling and computational approaches in precision medicine.Highlights the progress towards precision medicine.Advances Path to Cures | | 圖書封面 |  | | 影響因子 | .Accelerated Path to Cures provides a transformative perspective on the power of combining advanced computational technologies, modeling, bioinformatics and machine learning approaches with nonclinical and clinical experimentation to accelerate drug development. This book discusses the application of advanced modeling technologies, from target identification and validation to nonclinical studies in animals to Phase 1-3 human clinical trials and post-approval monitoring, as alternative models of drug development. As a case of successful integration of computational modeling and drug development, we discuss the development of oral small molecule therapeutics for inflammatory bowel disease, from the application of docking studies to screening new chemical entities to the development of next-generation .in silico. human clinical trials from large-scale clinical data. Additionally, this book illustrates how modeling techniques, machine learning, and informatics can be utilized effectively at each stage of drug development to advance the progress towards predictive, preventive, personalized, precision medicine, and thus provide a successful framework for Path to Cures.?. | | Pindex | Book 2018 |
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