Titlebook: Whole Organ Approaches to Cellular Metabolism; Permeation, Cellular James B. Bassingthwaighte,John H. Linehan,Carl A. Book 1998 Springer-V

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Norepinephrine Kinetics in Normal and Failing Myocardium: The Importance of Distributed Modeling he originated or promoted have not only illuminated normal blood tissue transport but also led to significant insights into a clinical problem. When, as a medical student and intern, I read the Ziegler and Goresky papers on multiple indicator dilution experiments in the heart of open-chest dogs I w

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Metabolic Response Times: A Generalization of Indicator Dilution Theory Applied to Cardiac O2 Consumsteady state. However, the time courses of changing metabolic fluxes are difficult to assess, because the investigator can often only measure outside the organ. Such metabolic transients occur when the organ is in a transition from a metabolic steady state to another level of metabolic steady state.

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Role of Capillary Endothelial Cells in Transport and Metabolism of Adenosine in the Heart: An Examplng blood solute concentrations or sensing intravascular shear can lead to the endothelial production of substances sensed or taken up by other cells. The interactions between endothelium and smooth muscle fall into a special class relating to the regulation of vasomotion. A component of the vasoregu

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Distribution of Intravascular and Extravascular Resistances to Oxygen Transportn the production of ATP—the common source of energy in living cells. It has been shown that in many organs, including myocardium and skeletal muscle, the structure of the circulatory system is closely correlated with the function of adequate oxygen delivery (Weibel, 1984; Weibel et al., 1991). Oxyge

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Liver Cell Entry In Vivo and Enzymic Conversions only a simple barrier to parenchymal cell entry of substrates. The situation is not simple, however, because interposed between the vascular lumen and cell membrane there is an interstitial space that modifies access of molecules to the liver cell surface. The barrier itself is generally not passi

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Probing the Structure and Function of the Liver with the Multiple-Indicator Dilution Technique drug is often expressed as the hepatic drug clearance, or the volume of perfusing fluid cleared of its contained drug per unit time. Clearance is affected by the hepatic blood flow rate, the binding to vascular proteins, transport across the sinusoidal membrane, and the . . and . . of the metabolic

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A Generalized Mathematical Theory of the Multiple-Indicator Dilution Method dilution technique as a special form of a tracer method is particularly suitable for the study of relatively rapid processes occurring in intact organs. In the previous chapters, the principles and some important applications of the multiple-indicator dilution technique have been addressed. In this

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Book 1998s in Copenhagen resulted in the book Capillary Permeability: The Transfer of Mole- cules and Ions Between the Capillary Blood and the Tissue (Crone and Lassen, 1970). It focused on the physiochemical aspects of transcapillary water and solute transport. The field has matured considerably since. This

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Transport Functions of the Glycocalyx, Specific Proteins, and Caveolae in Endotheliume the main pathways and barriers to molecular transport across vascular endothelium. The emphasis will be on the specific transport proteins of the luminal endothelial cell glycocalyx with a special focus on those proteins associated with noncoated plasmalemmal vesicles or caveolae. Aquaporin and al