Titlebook: Waldenstr?m’s Macroglobulinemia; Véronique Leblond,Steve Treon,Meletios Dimoploulos Book 2017 Springer International Publishing Switzerlan

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Molecular Pathways in Growth and Survival: Epigenomicsetic markers is histone acetylation which has been shown to be deregulated in clonal disorders, including both solid tumors and B-cell malignancies, such as Waldenstrom’s Macroglobulinemia (WM). Importantly, recent evidences have suggested that WM cells present with an aberrant histone acetylation s

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The Bone Marrow Microenvironment and Tumor Cells Interactions in Waldenstr?m’s Macroglobulinemia(BM) is always involved and infiltrated by the monoclonal lymphoplasmacytic cells. Within the BM microenvironment WM cells thrive and produce IgM. BM microenvironment plays a critical role in the progression of the disease from the stage of MGUS to asymptomatic and symptomatic WM, and a permissive B

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Waldenstrom’s Macroglobulinaemia: Immunosurveillance and the Immune Micro-environmentnaemia (WM), there are measurable changes in the immune system with abnormalities of T-cells, NK cells and the ability to respond to external immunological stimuli. The homeostatic balance between the activation and suppression of immune antitumour effector cells in vivo is controlled by a network o

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Genetic Predisposition to Waldenstr?m MacroglobulinemiaGUS recognized as a precursor condition for WM. Following early observations of clustering of WM (and IgM-MGUS) in families, several lines of evidence have developed that support the hypothesis of a genetic component of WM susceptibility. Family studies have provided seminal observations in delineat

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