作者: Measured 時(shí)間: 2025-3-21 23:37
,The Role of Non-pore-Forming β Subunits in Physiology and Pathophysiology of Voltage-Gated Sodium Cn and migration, axon outgrowth, axonal fasciculation, and neuronal pathfinding. Mutations in genes encoding β subunits are linked to paroxysmal diseases including epilepsy, cardiac arrhythmia, and sudden infant death syndrome. Finally, β subunits may be targets for the future development of novel t作者: SIT 時(shí)間: 2025-3-22 01:15 作者: 消散 時(shí)間: 2025-3-22 08:13 作者: 發(fā)誓放棄 時(shí)間: 2025-3-22 11:06
The Role of Late ,, in Development of Cardiac Arrhythmias,tion. There are several distinct mechanisms of arrhythmogenesis due to abnormal late . ., including abnormal automaticity, early and delayed afterdepolarization-induced triggered activity, and dramatic increase of ventricular dispersion of repolarization. Many local anesthetic and antiarrhythmic age作者: 懶鬼才會(huì)衰弱 時(shí)間: 2025-3-22 13:44 作者: prosthesis 時(shí)間: 2025-3-22 17:21
Pharmacological Insights and Quirks of Bacterial Sodium Channels,scovery that bNavs are amenable to crystallographic study opens the door for the possibility of structure-guided rational design of the next generation of therapeutics that target eNavs. Here we summarize the gating behavior of these disparate channel members and discuss mechanisms of local anesthet作者: 業(yè)余愛好者 時(shí)間: 2025-3-22 23:40
t und Abschlu?prüfern l?sen lassen. Dies kommt zum Teil daher, da? Sinn und Ziel so mancher der geforderten Angaben zur Jahresbilanz nicht voll gekl?rt sind. Angesichts dieser Sachlage k?nnen die folgenden Ausführungen teilweise nur als ein erster Kommentierungsversuch betrachtet werden.作者: 引起痛苦 時(shí)間: 2025-3-23 02:32 作者: 疲憊的老馬 時(shí)間: 2025-3-23 07:38 作者: 增減字母法 時(shí)間: 2025-3-23 13:40
John Gilchrist,Baldomero M. Olivera,Frank Bosmansschiedlich. In manchen Kreditinstituten werden nur j?hrliche, in anderen halbj?hrliche, viertelj?hrliche oder sogar monatliche Gesamtbetriebskalkulationen durchgeführt. Bei den Sparkassen werden seit einigen Jahren kurzfristige Erfolgsrechnungen auf freiwilliger Grundlage durchgeführt. Es handelt si作者: 憤怒歷史 時(shí)間: 2025-3-23 14:07 作者: 戰(zhàn)役 時(shí)間: 2025-3-23 19:03 作者: BLANK 時(shí)間: 2025-3-23 23:53 作者: Ostrich 時(shí)間: 2025-3-24 04:45 作者: 幾何學(xué)家 時(shí)間: 2025-3-24 10:06
0171-2004 y are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.978-3-662-51202-9978-3-642-41588-3Series ISSN 0171-2004 Series E-ISSN 1865-0325 作者: 2否定 時(shí)間: 2025-3-24 11:03 作者: nepotism 時(shí)間: 2025-3-24 15:54
Charles Antzelevitch,Vladislav Nesterenko,John C. Shryock,Sridharan Rajamani,Yejia Song,Luiz Belardi作者: insipid 時(shí)間: 2025-3-24 19:08
Book 2014ctives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.作者: Arthritis 時(shí)間: 2025-3-25 00:51 作者: Perineum 時(shí)間: 2025-3-25 05:53 作者: 消息靈通 時(shí)間: 2025-3-25 08:03 作者: bioavailability 時(shí)間: 2025-3-25 11:53
John Gilchrist,Baldomero M. Olivera,Frank Bosmans überblick ist am besten durch eine Gesamtbetriebskalkulation zu gewinnen. Unter dem Begriff der Gesamtbetriebskalkulation ist daher eine Rechnung zu verstehen, die die ?Aufwendungen einer Periode deren Ertr?gnissen gegenüberstellt“, wie Isaac feststellte.). In dieser Definition mü?ten heute allerdi作者: Androgen 時(shí)間: 2025-3-25 16:25 作者: Ataxia 時(shí)間: 2025-3-25 23:22 作者: LATHE 時(shí)間: 2025-3-26 03:16
Todd ScheuerArthritis (RA) zu geh?ren, obwohl der Erfolg einer über mehrere Jahre gehenden Behandlung mit solchen Medikamenten aufgrund von wenigen Langzeituntersuchungen nicht mehr kritiklos angenommen werden kann. Ein wesentliches Problem der bisherigen Langzeittherapie war der hohe Prozentsatz von Nebenwirku作者: AGATE 時(shí)間: 2025-3-26 05:10
at festzusetzenden Zeitpunkt in Kraft treten sollte. Es brachte die vollst?ndige Verstaatlichung der B?rse, als deren Zweck die Erleichterung des Verkehrs in Wertpapieren (Namen- und Inhaberpapiere mit Ausnahme der Wechsel und wechsel?hnlichen Papiere) bezeichnet wurde. Mit der Bestimmung, dass Sond作者: 生來 時(shí)間: 2025-3-26 12:10
Peter C. RubenGives unprecedented insight into the structural basis of sodium channel function.Explores sodium channels from the perspectives of their biophysical behavior.Written by leading experts in the field.In作者: 經(jīng)典 時(shí)間: 2025-3-26 15:05
Handbook of Experimental Pharmacologyhttp://image.papertrans.cn/v/image/984210.jpg作者: 討厭 時(shí)間: 2025-3-26 19:19 作者: 館長 時(shí)間: 2025-3-26 22:09 作者: 龍蝦 時(shí)間: 2025-3-27 04:05 作者: EWER 時(shí)間: 2025-3-27 05:25 作者: deficiency 時(shí)間: 2025-3-27 11:48
Slow Inactivation of Na+ Channels,ures myocytes are able to contract when K. is elevated. The molecular mechanisms underlying slow inactivation are unclear even though it has been studied for 50+ years. This chapter reviews what is known to date regarding the definition, measurement, and mechanisms of voltage-gated Na. channel slow inactivation.作者: progestogen 時(shí)間: 2025-3-27 17:34 作者: Hot-Flash 時(shí)間: 2025-3-27 19:39 作者: omnibus 時(shí)間: 2025-3-28 01:43 作者: Fillet,Filet 時(shí)間: 2025-3-28 04:02 作者: GIBE 時(shí)間: 2025-3-28 08:42
Slow Inactivation of Na+ Channels, reducing availability of inward current. In neurons, slow inactivation has been linked to memory of previous excitation and in skeletal muscle it ensures myocytes are able to contract when K. is elevated. The molecular mechanisms underlying slow inactivation are unclear even though it has been stud作者: 招致 時(shí)間: 2025-3-28 11:37
,The Role of Non-pore-Forming β Subunits in Physiology and Pathophysiology of Voltage-Gated Sodium Cfamily members, β1B, β3, and β4, were identified by homology and shown to modulate sodium current in heterologous systems. Work over the past 2 decades, however, has provided strong evidence that these proteins are not simply ancillary ion channel subunits, but are multifunctional signaling proteins作者: Peculate 時(shí)間: 2025-3-28 16:59 作者: 難管 時(shí)間: 2025-3-28 20:00
Regulation/Modulation of Sensory Neuron Sodium Channels,imuli into electrical signals that are transmitted via central branches to the spinal cord. These neurons express unique combinations of tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) Na. channels that contribute to the resting membrane potential, action potential threshold, and r作者: 仔細(xì)檢查 時(shí)間: 2025-3-29 02:27
The Role of Late ,, in Development of Cardiac Arrhythmias,vely small in all species and in all types of cardiomyocytes as compared with the amplitude of the fast sodium current, but it contributes significantly to the shape and duration of the action potential. This late component had been shown to increase in several acquired or congenital conditions, inc作者: 窗簾等 時(shí)間: 2025-3-29 06:35
Proton Modulation of Cardiac ,,: A Potential Arrhythmogenic Trigger,mediating cardiac excitability. Cardiac ischemia triggers extracellular pH to drop as low as pH 6.0, within just 10 min of its onset. Heightened proton concentrations reduce sodium conductance and alter the gating parameters of the cardiac-specific voltage-gated sodium channel, Na.1.5. Most notably,作者: intellect 時(shí)間: 2025-3-29 10:09
Probing Gating Mechanisms of Sodium Channels Using Pore Blockers,ar side of the membrane and block ion conduction through the pore. Biophysical studies that shed light on the chemical nature, accessibility, and kinetics of binding of these naturally occurring and synthetic compounds reveal a wealth of information about how these channels gate. Here, we discuss in作者: 你不公正 時(shí)間: 2025-3-29 11:25
Animal Toxins Influence Voltage-Gated Sodium Channel Function,toxins found in animal venoms. These molecules can be used to probe the functional aspects of Nav channels on a molecular level and to explore their physiological role in normal and diseased tissues. This chapter summarizes our existing knowledge of the mechanisms by which animal toxins influence Na作者: Eosinophils 時(shí)間: 2025-3-29 17:04 作者: perimenopause 時(shí)間: 2025-3-29 22:28 作者: Fecundity 時(shí)間: 2025-3-30 00:58
Bacterial Sodium Channels: Models for Eukaryotic Sodium and Calcium Channels,prised of four identical subunits, each being analogous to a single homologous domain of their eukaryotic counterparts. Key elements of primary structure are conserved between bacterial and eukaryotic sodium and calcium channels. The simple protein structure of the bacterial channels has allowed ext作者: flaunt 時(shí)間: 2025-3-30 04:08
Book 2014cists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in cryst作者: headway 時(shí)間: 2025-3-30 10:45
