標(biāo)題: Titlebook: Virtual Screening: An Alternative or Complement to High Throughput Screening?; Proceedings of the W Gerhard Klebe Conference proceedings 20 [打印本頁(yè)] 作者: ACORN 時(shí)間: 2025-3-21 16:13
書(shū)目名稱Virtual Screening: An Alternative or Complement to High Throughput Screening?影響因子(影響力)
書(shū)目名稱Virtual Screening: An Alternative or Complement to High Throughput Screening?影響因子(影響力)學(xué)科排名
書(shū)目名稱Virtual Screening: An Alternative or Complement to High Throughput Screening?網(wǎng)絡(luò)公開(kāi)度
書(shū)目名稱Virtual Screening: An Alternative or Complement to High Throughput Screening?網(wǎng)絡(luò)公開(kāi)度學(xué)科排名
書(shū)目名稱Virtual Screening: An Alternative or Complement to High Throughput Screening?被引頻次
書(shū)目名稱Virtual Screening: An Alternative or Complement to High Throughput Screening?被引頻次學(xué)科排名
書(shū)目名稱Virtual Screening: An Alternative or Complement to High Throughput Screening?年度引用
書(shū)目名稱Virtual Screening: An Alternative or Complement to High Throughput Screening?年度引用學(xué)科排名
書(shū)目名稱Virtual Screening: An Alternative or Complement to High Throughput Screening?讀者反饋
書(shū)目名稱Virtual Screening: An Alternative or Complement to High Throughput Screening?讀者反饋學(xué)科排名
作者: 整體 時(shí)間: 2025-3-21 23:13 作者: expound 時(shí)間: 2025-3-22 02:24
Generating consistent sets of thermodynamic and structural data for analysis of protein-ligand inteputational chemistry. Understanding the energetics of protein-ligand interactions would not only provide powerful tools for prediction in structure-assisted ligand and library design, but also enrich our appreciation of the subtleties of structure that underlie molecular recognition in biological sy作者: 強(qiáng)壯 時(shí)間: 2025-3-22 04:57 作者: dilute 時(shí)間: 2025-3-22 11:23 作者: Germinate 時(shí)間: 2025-3-22 13:55 作者: 與野獸博斗者 時(shí)間: 2025-3-22 18:14 作者: NEX 時(shí)間: 2025-3-23 00:32 作者: abolish 時(shí)間: 2025-3-23 04:11
Virtual screening with solvation and ligand-induced complementarity,site of a target protein. Its main feature is the modeling of induced complementarity by making adjustments in the protein side chains and ligand upon binding. Mean-field theory is used to balance the conformational changes in both molecules in order to generate a shape-complementary inter-face. Sol作者: TAG 時(shí)間: 2025-3-23 06:19
Similarity versus docking in 3D virtual screening,similarity methods to a level of performance comparable to the well established protein-ligand docking methods for binding mode assessment and molecular database screening. However, the strengths and intrinsic limitations of both methodologies have been also stressed out extensively. As the number o作者: 芭蕾舞女演員 時(shí)間: 2025-3-23 10:44
Discovering high-affinity ligands from the computationally predicted structures and affinities of ss into the active site of an enzyme and score them. Keeping the tightest-binding lead fixed in space, we dock and score other small molecules in its presence. Using this approach, linker groups are used to join the compounds together to form a high-affinity inhibitor. We present validation of our co作者: rectum 時(shí)間: 2025-3-23 17:52
and , affinity fingerprints: Finding similarities beyond structural classes,ses. An affinity fingerprint for a particular molecule is constructed as a vector of either its binding affinities, docking scores or superpositioning pseudo energies against a reference panel of proteins or small molecules. In contrast to most other molecular descriptors, affinity fingerprints are 作者: 反對(duì) 時(shí)間: 2025-3-23 18:03 作者: Cocker 時(shí)間: 2025-3-23 22:14 作者: GAVEL 時(shí)間: 2025-3-24 03:16 作者: 蒸發(fā) 時(shí)間: 2025-3-24 08:58
genes as well as the complete genome for manymicro-organisms. Subsequently it is hoped, by means of powerfulbioinformatic tools, to determine the gene variants that contribute tovarious multifactorial diseases and genes that exist in certaininfectious agents but not humans. As a consequence, this w作者: 翅膀拍動(dòng) 時(shí)間: 2025-3-24 11:03
Holger Gohlke,Manfred Hendlich,Gerhard Klebeas a data mining technique in the domain of tissue engineering and initiates a new promising research field. The experimental results show that the proposed approach performs well with respect to the accuracy of (classification) prediction. Moreover, it was found that some rules mined from the constructed MSC database are meaningful and useful.作者: 神圣不可 時(shí)間: 2025-3-24 17:15
Valerie J. Gillet,Orazio Nicolottiapers are organized in topical sections on?Cyber Security;??Data Science;??Information Technology and Applications;?Network and IoT.?.978-3-030-36367-3978-3-030-36368-0Series ISSN 1865-0929 Series E-ISSN 1865-0937 作者: cardiovascular 時(shí)間: 2025-3-24 20:23 作者: GUEER 時(shí)間: 2025-3-25 02:14
Ingo Mueggeaddressed in the data mining community, we hypothesize that this community has much to contribute to the worldwide efforts worldwide to Assemble the Tree Of Life. Phylsyst is such an attempt, and has been successfully distributed worldwide as a digital supplement to a special issue of Biosystema journal.作者: 演講 時(shí)間: 2025-3-25 05:17 作者: PANG 時(shí)間: 2025-3-25 10:29 作者: LURE 時(shí)間: 2025-3-25 15:30 作者: IRS 時(shí)間: 2025-3-25 19:31 作者: 情節(jié)劇 時(shí)間: 2025-3-25 19:58 作者: 殘廢的火焰 時(shí)間: 2025-3-26 02:05 作者: 急性 時(shí)間: 2025-3-26 06:07
Nicolas Majeux,Marco Carsi,Catherine Tenette-Souaille,Amedeo Caflischeholds. Different clustering algorithms are assessed by the consistency of the results..Findings show that variability of behaviour, using motifs, provides more consistent groupings of households across different clustering algorithms and allows for more efficient targeting of behaviour change interventions.作者: 小母馬 時(shí)間: 2025-3-26 09:33 作者: Glucocorticoids 時(shí)間: 2025-3-26 15:25
he experimental results yield 96% detection accuracy. The detection and prevention processes take less than 3?s. The results show the feasibility of the methodology followed in this paper under different attack conditions and show the high robustness of the proposed system.作者: 開(kāi)始從未 時(shí)間: 2025-3-26 20:05 作者: Affable 時(shí)間: 2025-3-26 23:17 作者: 諂媚于性 時(shí)間: 2025-3-27 01:17 作者: justify 時(shí)間: 2025-3-27 06:20 作者: 小步舞 時(shí)間: 2025-3-27 12:23 作者: 悅耳 時(shí)間: 2025-3-27 16:24
Claire M.R. Ginn,Peter Willett,John Bradshaw this paper using two kinds of chaotic maps (1D logistic map and Chebyshev map). The proposed enhanced Salsa20 (ESalsa20) algorithm is developed to be utilized as a lightweight stream cipher that can be implemented in such a way that the speed of encryption is as important as the security. This enha作者: 欺騙世家 時(shí)間: 2025-3-27 20:24
Jens Sadowskis and administrators. There are many schemes based on factors such as smart cards, biometrics, and token devices. Although these schemes are generally strong, they suffer from several drawbacks such as malicious attacks, factors that may be lost/stolen, and a need for extra hardware/software. In thi作者: 流眼淚 時(shí)間: 2025-3-27 22:10
Thomas G. Davies,Jeremy R.H. Tame,Roderick E. Hubbardrom those images. For any watermarking scheme, there are four main requirements which are imperceptibility, Robustness, capacity and security. Recently, hybrid Singular Value Decomposition (SVD) based watermarking schemes in the transform domain have significantly gained a lot of attention. This is 作者: Sad570 時(shí)間: 2025-3-28 02:51
Christian Lemmen,Marc Zimmermann,Thomas Lengauerr and in the occurance of other pathologicalevents. DNA damage caused by reactive oxygen-derived species, alsocalled oxidative DNA damage, is most the frequent type encountered byaerobic cells. Mechanistic studies of carcinogenesis indicate animportant role of this type of damage to DNA. There is al作者: 充氣球 時(shí)間: 2025-3-28 07:32 作者: Chemotherapy 時(shí)間: 2025-3-28 14:08
Martin Stahlwo subrelations whose union is the given relation. This horizontal decomposition induces a new constraint: the ., which is the “opposite” of the well known functional dependency. The membership problem for this constraint is solved..Two normal forms are proposed for this decomposition. The Clean Nor作者: 單色 時(shí)間: 2025-3-28 15:39 作者: 1FAWN 時(shí)間: 2025-3-28 20:10
Holger Gohlke,Manfred Hendlich,Gerhard Klebe which, we believe, influence the destiny of mammalian MSCs has been constructed. This paper introduces Classification Association Rule Mining (CARM) as a data mining technique in the domain of tissue engineering and initiates a new promising research field. The experimental results show that the pr作者: intrigue 時(shí)間: 2025-3-28 23:16
Nicolas Majeux,Marco Carsi,Catherine Tenette-Souaille,Amedeo Caflisch. Work on clustering similar households has concentrated on daily load profiles and the variability in regular household behaviours has not been considered. Those households with most variability in regular activities may be the most receptive to incentives to change timing. Whether using the variab作者: POINT 時(shí)間: 2025-3-29 04:54 作者: 似少年 時(shí)間: 2025-3-29 08:46
Jordi Mestres,Ronald M.A. Knegtelt the main stress is focussed on the experimental studies, the aim of which was to examine its usefulness in knowledge discovery and rule extraction for classification task of medical data. The tests were made using the well-known benchmark data sets from UCI, as well as two other data sets collecte作者: 牌帶來(lái) 時(shí)間: 2025-3-29 14:40 作者: fibroblast 時(shí)間: 2025-3-29 18:05
Hans Briem,Uta F. Lessele multiple models-based controller operating in the training region is superior to the integrating controller. However, for data originating from outside the multiple models training region, the integrating controller has the advantage. It is, therefore, suggested to combine the two techniques in or作者: diabetes 時(shí)間: 2025-3-29 20:18 作者: Champion 時(shí)間: 2025-3-30 03:32
Valerie J. Gillet,Orazio Nicolottih, Saudi Arabia, in December 2019.?.The two-volume set presents 53 full papers, which were carefully reviewed and selected from 174 submissions. The papers are organized in topical sections on?Cyber Security;??Data Science;??Information Technology and Applications;?Network and IoT.?.978-3-030-36367-作者: 芳香一點(diǎn) 時(shí)間: 2025-3-30 07:01
erhead analysis, and tracing. In this article, an intrusion detection and prevention system (IDPS) is proposed and implemented using SNORT and Security Onion tools to detect and prevent anomaly intrusion; misuse of protocol and service ports, DoS based on crafted payloads, DoS based on volume (DDoS)作者: reflection 時(shí)間: 2025-3-30 10:27
http://image.papertrans.cn/v/image/983375.jpg作者: 玉米棒子 時(shí)間: 2025-3-30 15:51
https://doi.org/10.1007/0-306-46883-2chemistry; drug; drugs; future; research作者: 災(zāi)禍 時(shí)間: 2025-3-30 19:51 作者: 散布 時(shí)間: 2025-3-30 22:01 作者: 左右連貫 時(shí)間: 2025-3-31 03:25
Modifications of the scoring function in FlexX for virtual screening applications, thereby gain larger weight than others formed at the protein surface. The modified scoring function is tested with thrombin as a target. Secondly, a recently published knowledge-based scoring function is compared to the FlexX scoring function in several database ranking experiments.作者: 有機(jī)體 時(shí)間: 2025-3-31 06:30 作者: Inclement 時(shí)間: 2025-3-31 11:42 作者: 洞察力 時(shí)間: 2025-3-31 14:29
