標(biāo)題: Titlebook: Viral Vectors for Gene Therapy; Methods and Protocol Curtis A. Machida Book 2003 Humana Press 2003 [打印本頁] 作者: AMASS 時間: 2025-3-21 19:07
書目名稱Viral Vectors for Gene Therapy影響因子(影響力)
書目名稱Viral Vectors for Gene Therapy影響因子(影響力)學(xué)科排名
書目名稱Viral Vectors for Gene Therapy網(wǎng)絡(luò)公開度
書目名稱Viral Vectors for Gene Therapy網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Viral Vectors for Gene Therapy被引頻次
書目名稱Viral Vectors for Gene Therapy被引頻次學(xué)科排名
書目名稱Viral Vectors for Gene Therapy年度引用
書目名稱Viral Vectors for Gene Therapy年度引用學(xué)科排名
書目名稱Viral Vectors for Gene Therapy讀者反饋
書目名稱Viral Vectors for Gene Therapy讀者反饋學(xué)科排名
作者: acclimate 時間: 2025-3-21 20:53 作者: insomnia 時間: 2025-3-22 03:09
Curtis A. MachidaIncludes supplementary material: 作者: Pelvic-Floor 時間: 2025-3-22 05:33 作者: 聽覺 時間: 2025-3-22 09:37
Viral Vectors for Gene Therapy978-1-59259-304-0Series ISSN 1543-1894 Series E-ISSN 1940-6037 作者: Ccu106 時間: 2025-3-22 13:16 作者: 大都市 時間: 2025-3-22 17:54 作者: Fester 時間: 2025-3-22 23:39 作者: IVORY 時間: 2025-3-23 03:15 作者: CAND 時間: 2025-3-23 07:08
Charles J. Link,Nicholas N. Vahanian,Suming Wangrential constraints for capturing continuous flows. Formal verification of hybrid automata relies on symbolic fixpoint computation procedures that manipulate sets of states. These procedures can be implemented using boolean combinations of linear constraints over system variables, equivalently, usin作者: 管理員 時間: 2025-3-23 13:26
Catherine R. O’Riordan,Antonius Song,Julia Lanciotti. Applications, such as military surveillance and large scale assisted living facilities are key examples of applications that can benefit from WSN. Current research for WSN is widespread. However, many of the proposed solutions are developed with simplifying assumptions about wireless communication作者: 寄生蟲 時間: 2025-3-23 14:37 作者: ALTER 時間: 2025-3-23 19:37
Matthew D. Weitzman,Samuel M. Young Jr.,Toni Cathomen,Richard Jude Samulskiekte der . in der Prosa werfen m?gen — die . ist mehr als nur eine Reaktion auf Modernisierung. Im Zuge der ersten industriellen Revolution in den Niederlanden im letzten Drittel des 19. Jahrhunderts mu? der Modernisierungsdruck wohl mindestens so gro? gewesen sein wie bei der relativ langsamen Mode作者: 食物 時間: 2025-3-24 01:40
Matthew J. During,Deborah Young,Kristin Baer,Patricia Lawlor,Matthias Klugmanngsvorteil immer h?ufiger und mit zunehmender Vehemenz gestellt wird. Gleichzeitig bieten die neuartigen M?glichkeiten, die mit dem Einsatz neuer Fertigungs-, Information- und Kommunikationstechnologien verbunden, offensichtlich auch die M?glichkeit dazu. Zwischen den skizzierten Anforderungen auf de作者: glowing 時間: 2025-3-24 02:20 作者: 使隔離 時間: 2025-3-24 07:01 作者: Locale 時間: 2025-3-24 11:11
Thomas W. Dubensky Jr.,Sybille L. Sautere of the following three larger bodies of literature, namely: Japanization or Transplant, Institutionalist and International Business literature. While not all contributions can be exclusively classified as one or the other, most contributions can be subsumed under either of these bodies of literatu作者: 沖突 時間: 2025-3-24 15:24
Karen Morse,John Olsenrge amounts of a single immunoglobulin molecule, which could not be obtained from normal immune sera. The discovery that multiple myelomas were tumors originating from a single clone of antibody-producing cells and hence gave rise to a homogeneous source of immunoglobulin was therefore extremely imp作者: 演講 時間: 2025-3-24 22:21 作者: cliche 時間: 2025-3-25 00:14
We have implemented the new algorithm in a successor tool to . called .. We consider three examples: a thermostat with delay, a two-tank water system, and an air-traffic collision avoidance protocol. . enables the direct, fully automatic analysis of these systems, which is also more accurate than th作者: 無底 時間: 2025-3-25 05:36 作者: 有效 時間: 2025-3-25 11:00 作者: endoscopy 時間: 2025-3-25 12:18
Yoshinaga Saeki,Xandra O. Breakefield,E. Antonio Chioccae length of counterexample. We identify a syntactic condition for which the approach is complete in the sense that the underapproximation is empty only if the problem has no solution. Experimental results are provided for two CEGAR methods, a simple discrete version and iterative relaxation abstract作者: 羞辱 時間: 2025-3-25 17:06
Charles J. Link,Nicholas N. Vahanian,Suming Wangmata for describing flows without sacrificing the polyhedral property. In particular, we consider flows described by ., in which the allowed rates depend, not only on the current control mode, but also on the specific state at which the mode was entered. We establish that flows described by origin-d作者: 窒息 時間: 2025-3-25 23:21
Catherine R. O’Riordan,Antonius Song,Julia Lanciottid in a realistic, large-area environment. Technical details and evaluations are presented for several of the key services. In developing such systems various types of control challenges occur. I will also discuss a number of these challenges, possible solutions and open challenges.作者: aerobic 時間: 2025-3-26 03:54 作者: gain631 時間: 2025-3-26 06:00 作者: 敲詐 時間: 2025-3-26 09:37 作者: Vsd168 時間: 2025-3-26 15:45
Roy F. Collaco,James P. Trempenken und in der Art der Integration besteht, und erst in zweiter Linie in der besonderen Form der verwendeten Formalismen. Den Leser, der an einer (anspruchs)volleren Definition der verschiedenen Formalismen interessiert ist, verweisen wir auf das Referenzhandbuch des Systems (Brewka/di Primio/Gro? 作者: NEX 時間: 2025-3-26 17:27 作者: Felicitous 時間: 2025-3-26 23:10
Thomas W. Dubensky Jr.,Sybille L. Sauter a comparison of the strengths and weaknesses of the different bodies of literature. It is shown that no one approach makes an effort to relate systematically the hybridization of subsidiary production systems to the impact of both the strategic and institutional distance and to strategic choices at作者: 痛苦一下 時間: 2025-3-27 04:10 作者: Genteel 時間: 2025-3-27 06:07 作者: Irremediable 時間: 2025-3-27 09:33
1543-1894 for the construction, development, and use of viral vectors for gene transfer and gene therapy. I would like to thank the many chapter authors for their contributions. They are all experts in v978-1-61737-308-4978-1-59259-304-0Series ISSN 1543-1894 Series E-ISSN 1940-6037 作者: artless 時間: 2025-3-27 16:27
Andres Hurtado-Lorenzo,Anne David,Clare Thomas,Maria G. Castro,Pedro R. Lowenstein作者: 怕失去錢 時間: 2025-3-27 18:01 作者: 修剪過的樹籬 時間: 2025-3-27 23:11
Semyon Rubinchik,Jan Woraratanadharm,Jennifer Schepp,Jian-yun Dong作者: STEER 時間: 2025-3-28 02:19 作者: recede 時間: 2025-3-28 08:54 作者: 向前變橢圓 時間: 2025-3-28 11:14
Strategies to Adapt Adenoviral Vectors for Targeted Delivery,ing can be achieved at the level of capsid binding or at later transduction events by the use of tissue-specific promoters (.–.). Targeting at the level of binding is preferred because even the interaction of cells with empty capsids leads to toxic effects (.), however a combination of both strategi作者: Buttress 時間: 2025-3-28 15:57
Packaging Cell Lines for Generating Replication-Defective and Gutted Adenoviral Vectors,f the vectors. In general, two types of alterations are made to the Ad genome. In the first, individual genes, or combinations thereof, are deleted from the Ad genome and placed into a packaging cell line under control of a constitutive or inducible promoter. In the second method, all viral genes ar作者: Ccu106 時間: 2025-3-28 22:23
Improving the Transcriptional Regulation of Genes Delivered by Adenovirus Vectors,foreign genes. However, each virus has evolved to optimize its own life cycle and consequently endows vectors based on it with properties and limitations that affect their suitability as choices for various gene therapy applications. These properties need to be understood and taken into account in o作者: Junction 時間: 2025-3-29 01:08
A Method for Helper Virus-Free Production of Adeno-Associated Virus Vectors,ning multiple AAV vector constructions. To lay the foundation for the development of this and other AAV packaging systems, a brief summary of AAV biology is provided later. More detailed reviews describing AAV and its derived vectors are available in (. and .).作者: maintenance 時間: 2025-3-29 06:30 作者: ungainly 時間: 2025-3-29 07:17
Trans-Splicing Vectors Expand the Packaging Limits of Adeno-Associated Virus for Gene Therapy Applin demonstrated in small and large animal models. Phase I dose-escalation studies in hemophilia B patients presented favorable clinical outcomes in the absence of significant toxicity and germline transmission (.). The success of AAV gene therapy relies on several salient features of the vector syste作者: 可卡 時間: 2025-3-29 15:05 作者: Astigmatism 時間: 2025-3-29 19:05 作者: Antagonist 時間: 2025-3-29 22:37 作者: Picks-Disease 時間: 2025-3-30 03:05
In Vivo Infection of Mice by Replication-Competent MLV-Based Retroviral Vectors,h in the laboratory and in the clinic .for reviews, ...–.). the retroviral vector in its pro viral form. Culture supernatants are collected and, after possible concentration of retroviruses, subsequently used for infection of cells of interest (.–.).作者: 下級 時間: 2025-3-30 05:16 作者: Wallow 時間: 2025-3-30 11:10 作者: collateral 時間: 2025-3-30 16:22 作者: Mendicant 時間: 2025-3-30 17:07
1543-1894 iruses, adenoviruses, adeno-associated viruses, simple and complex retroviruses, including lentiviruses, and other virus systems for vector development and gene transfer. Chapter cont- butions provide perspective in the use of viral vectors for applications in the brain and in the central nervous sy作者: mortuary 時間: 2025-3-30 21:13 作者: Resistance 時間: 2025-3-31 02:38 作者: GNAT 時間: 2025-3-31 05:04
Construction of Multiply Disabled Herpes Simplex Viral Vectors for Gene Delivery to the Nervous Sys before describing the methodology in detail, it is important to briefly consider the structure and life cycle of HSV1 and the modifications that must be made to the virus in order to generate an efficient gene delivery vector.作者: 巧思 時間: 2025-3-31 12:19 作者: mitten 時間: 2025-3-31 14:05 作者: JIBE 時間: 2025-3-31 20:58
Strategies to Adapt Adenoviral Vectors for Targeted Delivery,fficient gene expression in the affected tissue, while minimizing toxicity and expression in other tissues. The use of recombinant adenoviruses as vectors for gene therapy is restricted by the widespread distribution of the coxsackie and adenovirus receptor (CAR) (.,.), which allows infection of a r作者: 潰爛 時間: 2025-3-31 23:34
Use of Recombinant Adenovirus for Gene Transfer into the Rat Brain,mal models of human disease and in several human phase I clinical trials (.–.). Adenoviruses are easily purified to the high titers required for in vivo administration and they are efficient in transducing terminally differentiated cells such as neurons and glial cells, resulting in high levels of t作者: –scent 時間: 2025-4-1 02:20 作者: Polydipsia 時間: 2025-4-1 06:37
Packaging Cell Lines for Generating Replication-Defective and Gutted Adenoviral Vectors,r genome that encodes numerous overlapping open reading frames (.). Because wild-type Ad is infectious to humans, vectors used in the laboratory generally contain a deletion of one or more genes to limit their growth and replication on nonpermissive cells. One drawback to Ad vectors is that infectio作者: 堅(jiān)毅 時間: 2025-4-1 11:08 作者: 溝通 時間: 2025-4-1 17:59
Targeted Integration by Adeno-Associated Virus,ne therapy applications. Expression of foreign genes in eukaryotic cells is highly dependent upon the efficiency of integration events and the site of insertion. Integration can sometimes have detrimental effects on the host cell, such as insertional mutagenesis or activation of proto-oncogenes. For作者: liaison 時間: 2025-4-1 20:06
Development and Optimization of Adeno-Associated Virus Vector Transfer into the Central Nervous Syslization of the potential of gene therapy for neurological disorders and functional genomic analysis in the brain remains a significant challenge and is largely limited by current technology. Efficient gene transfer to neurons remains a bottleneck for widespread molecular genetic studies of the nerv作者: Congeal 時間: 2025-4-1 23:26
A Method for Helper Virus-Free Production of Adeno-Associated Virus Vectors,adeno-associated virus (AAV), as a gene delivery vehicle. AAV vectors have been used to deliver genes to a wide variety of mammalian cells in culture, as well as to brain (.), retina (.,.), cochlea (.), skeletal muscle (.,.), cardiac muscle (.), liver (.), lung (.,.), central nervous system (.), and作者: 土產(chǎn) 時間: 2025-4-2 05:09
Novel Tools for Production and Purification of Recombinant Adeno-Associated Viral Vectors, with a rAAV plasmid vector (pAAV) and a helper/packaging plasmid, followed by over-infection with a helper virus, normally an adenovirus (Ad) at low multiplicity of infection (MOI) (.). The pAAV vector contains the transgene of interest flanked by the AAV inverted terminal repeats (ITRs) and the he作者: 宇宙你 時間: 2025-4-2 09:02 作者: 廣告 時間: 2025-4-2 13:30 作者: 費(fèi)解 時間: 2025-4-2 17:20 作者: CBC471 時間: 2025-4-2 19:41
An Ecdysone-Inducible Expression System for Use with Retroviruses, protein expressed needs to be tightly controlled, such as for gene therapy. Many systems are available that achieve high levels of induced gene expression while maintaining low basal expression in the absence of inducer. These systems vary, however, in levels of induction obtainable, toxicity of th
