作者: cuticle 時(shí)間: 2025-3-21 22:50 作者: Mundane 時(shí)間: 2025-3-22 02:26
highly experienced authority in the field of Cardiovascular.This unique work presents one of the most significant organ failure condition – cardiocirculatory shock – and the prominent role of Methylene Blue (MB). Through their extensive experience, the authors’ consider that the lifesaving feature 作者: instate 時(shí)間: 2025-3-22 07:38 作者: superfluous 時(shí)間: 2025-3-22 09:53 作者: 挑剔為人 時(shí)間: 2025-3-22 13:11 作者: Measured 時(shí)間: 2025-3-22 19:54
Introductionon uses several mechanisms (metabolic, myogenic, and neuroendocrine), and there is an essential interaction between all these mechanisms. The endothelium is responsible for the vascular tone’s paracrine regulation, emphasizing the scientific impact of establishing nitric oxide (NO) as a vasodilator 作者: receptors 時(shí)間: 2025-3-23 00:43
Physiology of the Endotheliumf endothelial function was not possible until the past two decades that witnessed the discovery of prostacyclin production, the subsequent discovery of endothelium-derived nitric oxide (NO), and other vasoactive factors. There are three known endothelium-dependent vasodilation mechanisms: (1) depend作者: considerable 時(shí)間: 2025-3-23 02:52 作者: 親愛 時(shí)間: 2025-3-23 08:44 作者: 懲罰 時(shí)間: 2025-3-23 11:19
Endothelial Dysfunction in Hemorrhagic Shockresuscitation and survival to treat hypovolemic states. Also, a study in dogs was conducted to assess prehospital resuscitation after refractory hemorrhagic shock with a combination of MB and lactated Ringer’s limited volume solution. Since the early 1990s, studies have investigated nitric oxide (NO作者: 濕潤 時(shí)間: 2025-3-23 17:43
Endothelial Dysfunction in Cardiogenic Shockmic inflammatory response (SIRS), complement activation, inflammatory cytokines release, inducible nitric oxide synthase (iNOS) expression, and vasodilation would not solely have a crucial position in the shock genesis but also on its evolution. Nowadays, cardiogenic shock, a devastating final resul作者: 寬宏大量 時(shí)間: 2025-3-23 19:45 作者: overture 時(shí)間: 2025-3-24 02:03
Methylene Bluecations, to date, regarding its safe use. Thus, its use does not mean the introduction of a new drug that implies scientific and ethical rigors. The toxic and therapeutic effects of MB are due to the interaction with the nitric oxide/cyclic guanosine 3′5′-cyclic monophosphate pathway (NO/cGMP). MB b作者: aptitude 時(shí)間: 2025-3-24 05:50
The Inhibition of Guanylate Cyclase by?Methylene Blue as a Therapeutic Proposal of Vasoplegia Associyclic monophosphate (cGMP), and it has been described for nearly 40?years after its identification in mammalian cells. Nitric oxide (NO) was described in the late 1970s as responsible for its activation and, therefore, for the formation of cGMP. Ten years later, when the endothelium-derived relaxing作者: 完整 時(shí)間: 2025-3-24 06:38
Methylene Blue in the Treatment of Anaphylaxisg the importance of histamine in anaphylactic shock (ASh) mediation, since when released and transported by the bloodstream, it can produce an effect on the entire cardiovascular system, in addition to other tissues where histaminergic receptors can also be found. One of the hypotheses that could ex作者: 機(jī)制 時(shí)間: 2025-3-24 13:58
Methylene Blue in Children and Neonatestreatment of shock are overly aggressive, and patients in shock have worse results showing a higher incidence of serious sequelae, for example, intraventricular cerebral hemorrhage. The main cause of distributive shock in children, especially neonatal patients, is septic shock. Mortality in sepsis i作者: Institution 時(shí)間: 2025-3-24 15:12 作者: 公社 時(shí)間: 2025-3-24 21:57 作者: 品嘗你的人 時(shí)間: 2025-3-25 00:33
Methylene Blue and Endocarditisammatory response because of infective endocarditis (IE) and those who need cardiopulmonary bypass (CPB) for emergency valve replacement may demonstrate resistant hypotension related to vasoplegia. It presents a spectrum of clinical presentation and is associated with a systemic inflammatory respons作者: Traumatic-Grief 時(shí)間: 2025-3-25 07:16 作者: Mast-Cell 時(shí)間: 2025-3-25 09:43
Book 2021B). Through their extensive experience, the authors’ consider that the lifesaving feature of MB is still underestimated. For this reason they outline key concepts of MB, mentioning essential experimental data, yet focusing mainly on its application in the care of critically ill patients...In an easy作者: Licentious 時(shí)間: 2025-3-25 14:13
Paulo Roberto Barbosa Evora,Andrea Carla Celotto,PCovers cardiocirculatory shock in a comprehensive yet easy-to-read format.Broadens understanding of Methylene Blue.Shares the knowledge of a highly experienced authority in the field of Cardiovascular作者: Blemish 時(shí)間: 2025-3-25 18:19 作者: 投票 時(shí)間: 2025-3-25 20:20
https://doi.org/10.1007/978-3-030-74096-2Vasoplegic endothelial dysfunction; Vasoplegia; Circulatory shock; Methylene blue; Endothelium; Nitric ox作者: cartilage 時(shí)間: 2025-3-26 02:49
978-3-030-74098-6The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl作者: FIS 時(shí)間: 2025-3-26 04:54
ithin the central nervous system that can produce or prevent chronic hypertension. Attempts to develop a suitable animal model of neurogenic model remain controversial. Baroreceptor denervation was thought to produce hypertension by way of unchecked increases in sympathetic outflow. However, protoco作者: 松雞 時(shí)間: 2025-3-26 09:25
irect) devices for home readings and fully automated monitors for 24-h profiles - have become a widely used necessary tool in clinical research. This book summarizes the state of the art in the whole field of indirect blood pressure monitoring. It is based on two international meetings and on invite作者: FER 時(shí)間: 2025-3-26 14:59
Paulo Roberto Barbosa Evora,Andrea Carla Celotto,Agnes Afrodite Sumarelli Albuquerque,Patricia Martih new information almost every month. In the 5 periodicals which have found their way to my desk during the past few days there are no less than 10 interesting articles on questions concerning shock research [see Bibliography 41 b, 53 a, 60 a, 192 a, 242 a, 350 b, 810 a, 941 a, 1069 a, 1082 a]. The 作者: 停止償付 時(shí)間: 2025-3-26 17:12
Paulo Roberto Barbosa Evora,Andrea Carla Celotto,Agnes Afrodite Sumarelli Albuquerque,Patricia Martigard to the principle that blood should . be replaced with blood. It is certain today that the total hepatitis frequency (non-icteric plus icteric cases) after blood transfusions is much higher than was previously assumed; thus one should stipulate that blood should be given only when the oxygen sup作者: senile-dementia 時(shí)間: 2025-3-27 00:00
Paulo Roberto Barbosa Evora,Andrea Carla Celotto,Agnes Afrodite Sumarelli Albuquerque,Patricia Martithe hematopoietic and/or lymphoid system. Suitable donors have been human leukocyte antigen (HLA) genotypically identical siblings. Given the current average family size, less than 30% of patients in North America have an HLA-matched sibling donor. This percentage can be increased by 3% to 5% if par作者: inspired 時(shí)間: 2025-3-27 03:10
Paulo Roberto Barbosa Evora,Andrea Carla Celotto,Agnes Afrodite Sumarelli Albuquerque,Patricia Martis. These essays were delivered as lectures by the authors at the second annual "Current Issues in Blood Substitute Research and Development - 1995" course sponsored jointly by the Departments of Medicine and Bioengineer- ing, University of California, San Diego, the National Institutes of Health (NH作者: Nonflammable 時(shí)間: 2025-3-27 08:47 作者: 參考書目 時(shí)間: 2025-3-27 11:11 作者: HAVOC 時(shí)間: 2025-3-27 13:36 作者: 離開可分裂 時(shí)間: 2025-3-27 18:46
of ca. 30). Shock provocation was carried out by stepwise withdrawal of blood (5 ml/kg body weight per 5 minutes). After a period of one hour at a PAo of 35 mmHg, the shed blood was reinfused..After reinfusion of the original volume of blood and stabilization for 30, 60, and 90 minutes, the control 作者: 大方一點(diǎn) 時(shí)間: 2025-3-27 22:21 作者: cancellous-bone 時(shí)間: 2025-3-28 02:15 作者: 玉米棒子 時(shí)間: 2025-3-28 08:03 作者: 展覽 時(shí)間: 2025-3-28 13:55 作者: 敘述 時(shí)間: 2025-3-28 17:43
Paulo Roberto Barbosa Evora,Andrea Carla Celotto,Agnes Afrodite Sumarelli Albuquerque,Patricia Martid thrombosis play a role. The bleeding disorders like hemophilia A are obvious but rare examples. Much more common is the other extreme: the excessive and unknown reaction of the hemostatic process known as thrombosis and its sequel embolism. Thrombosis on basis of atherosclerosis and thrombosis in 作者: 過分 時(shí)間: 2025-3-28 19:57
Paulo Roberto Barbosa Evora,Andrea Carla Celotto,Agnes Afrodite Sumarelli Albuquerque,Patricia Martitural landscape. Graphic descriptions of slave atrocities were regarded as a powerful cultural tool for critiquing European ‘civilised’ values. In order to point the finger of blame squarely at the European slave trade, anti-slavery writers developed a highly effective and influential repertoire of 作者: 長矛 時(shí)間: 2025-3-29 00:01 作者: 匯總 時(shí)間: 2025-3-29 04:18 作者: 解凍 時(shí)間: 2025-3-29 10:58 作者: 心胸開闊 時(shí)間: 2025-3-29 13:24
Circulatory Shock: A Conceptual and Practical Approachted early. The fundamental therapy objective is to treat the cause, correct the hemodynamic change, and, at the same time, neutralize abnormalities resulting from poor tissue perfusion. Based on these concepts, the pivotal role of vascular endothelium is made clear.作者: ALLEY 時(shí)間: 2025-3-29 18:38 作者: 評(píng)論性 時(shí)間: 2025-3-29 22:38 作者: 印第安人 時(shí)間: 2025-3-30 00:23 作者: Consequence 時(shí)間: 2025-3-30 07:16
Methylene Blueas been confirmed using experimental models of animals with damaged epithelium in the presence of MB. Given all the concepts discussed, the use of MB seems, at the moment, the most reasonable therapeutic proposal since it does not interfere with NO synthesis and because it is a medication widely use作者: 埋伏 時(shí)間: 2025-3-30 09:54
Methylene Blue in the Treatment of Anaphylaxistivating the adenosine 3′5′-cyclic monophosphate (cAMP) production pathway that also results in vasodilation. Thus, the vasodilation resulting from the activation of the cGMP and cAMP pathways synergistically contribute to the development and maintenance of the characteristic ASh hypotension. Theref作者: 薄荷醇 時(shí)間: 2025-3-30 16:13 作者: 整理 時(shí)間: 2025-3-30 17:47
Cardiac Arrest and Neuroprotection by?Methylene Bluee interruption of BBB permeability caused by ischemia/reperfusion injury. Methylene blue (MB), a nontoxic dye and scavenger cleaner, recently proved to be a potential aid in the resuscitation of cardiac arrest, attenuating oxidative, inflammatory, myocardial, and neurological lesions.作者: 驕傲 時(shí)間: 2025-3-30 21:13
Methylene Blue and Endocarditis(perhaps even earlier); (2) infusion of 1?mg.Kg. (intravenous (IV) or in the oxygenator) if blood pressure maintenance is not possible due to high perfusion flow and high doses of norepinephrine, and (3) repeat the infusion in bolus (or continuous if the patient is stable) after CPB discontinuity.作者: 遵循的規(guī)范 時(shí)間: 2025-3-31 03:31 作者: mydriatic 時(shí)間: 2025-3-31 08:00
of acid-base balance and the therapeutic use of inhaled nitric oxide are mentioned...Finally, looking for therapeutic alternatives for what we classify as "vasoplegic endothelial dysfunction", MB remains promis978-3-030-74098-6978-3-030-74096-2作者: 依法逮捕 時(shí)間: 2025-3-31 09:13
Paulo Roberto Barbosa Evora,Andrea Carla Celotto,Agnes Afrodite Sumarelli Albuquerque,Patricia Marti
