作者: 執(zhí) 時(shí)間: 2025-3-21 21:24
Pharmacological effects and mechanisms of actionin recent years, including use of valproate for diseases other than epilepsy, e.g. in bipolar disorders and migraine. In the following, the preclinical pharmacological profile of valproate and the putative mechanisms involved will be reviewed.作者: 驚奇 時(shí)間: 2025-3-22 03:39
Chemistry and biotransformationsign of new efficacious antiepileptic drugs having minimal sideeffects and free of the undesired interactions with other antiepileptic agents, structure-activity relationship studies of VPA analogues and metabolites have played a pivotal role towards the development of new antiepileptic agents [4–7]作者: 符合規(guī)定 時(shí)間: 2025-3-22 08:29 作者: Left-Atrium 時(shí)間: 2025-3-22 09:45
Book 1999 its unique distribution characteristics, its unwanted hepatotoxic and terato- genic adverse effects and its various clinical uses. Furthermore, the wide variety of available pharmaceutical formulations of valproate, including novel controlled-release formulations, will be outlined. The monograph is作者: 英寸 時(shí)間: 2025-3-22 15:57 作者: 袋鼠 時(shí)間: 2025-3-22 17:34 作者: stress-test 時(shí)間: 2025-3-23 00:30 作者: WAG 時(shí)間: 2025-3-23 04:45 作者: Cocker 時(shí)間: 2025-3-23 07:20
Frank S. Abbott,M. Reza Anari(SNR) of atomic shot noise and laser frequency noise. The estimated SNR of the designed cesium beam tube is over 7000 in a 1?Hz detection bandwidth. The influence of the deflection angle of the collimator on the performance of the beam tube is analyzed. The method can be used to guide the design of 作者: Judicious 時(shí)間: 2025-3-23 09:41
N. Sarisjulis,Olivier Dulaccombining demands of morality and rationality, that he employed for the representative case of British rule in India: the British treatment of India was simultaneously a colonial crime and an instrument of history, for, by breaking down the native social structure and relations, it produced “the onl作者: 征稅 時(shí)間: 2025-3-23 16:42
L. James Willmorestate-owned purchasing agencies, the extent to which private distributors have equal access to foreign exchange relative to the state-owned purchasing agencies, the extent to which industrial distribution channels can now be said to be shorter and more efficiently run as compared to the situation be作者: Enthralling 時(shí)間: 2025-3-23 20:25
Nathan B. Fountain,Fritz E. Dreifusshas become acutely aware of the need to address Latin American concerns about its impact in the agriculture sector. To do so, it is taking measures ranging from approvals for a wider range of Latin American food imports to commitments to invest in value-adding sectors of the region’s agriculture pro作者: Pseudoephedrine 時(shí)間: 2025-3-23 22:43 作者: 現(xiàn)任者 時(shí)間: 2025-3-24 03:29
ween satellites and stations. It is of great significance for the study of the temporal and spatial characteristics of the ionosphere and the monitoring of abnormal characteristics. The solar eclipse that occurred on June 21, 2020 provides an opportunity to study the impact of the solar eclipse on t作者: 謙卑 時(shí)間: 2025-3-24 08:23
Wolfgang L?schercost remote sensing technology, using the interference of GNSS direct and reflected signals to obtain environmental parameters, which can realize non-contact, large-scale, real-time and continuous soil moisture monitoring. In this paper, a random forest algorithm is proposed to conduct soil moisture作者: Ligament 時(shí)間: 2025-3-24 13:02 作者: Hallowed 時(shí)間: 2025-3-24 16:57 作者: prediabetes 時(shí)間: 2025-3-24 22:03
L. James WillmoreChina (PRC), and assesses their overall impact on organizational buyer—seller relationships in this environment. Data for the study were collected during the months of May through July 1996. The sample comprises 72 organizations (local and jointventure distributors/wholesalers) drawn from the Tianji作者: 植物群 時(shí)間: 2025-3-25 02:17 作者: Jargon 時(shí)間: 2025-3-25 07:15
The discovery of valproatey was serendipitously discovered by Pierre Eymard in France in 1962. Valproic acid (VPA; valproate; di-.-propylacetic acid, DPA; 2-propylpentanoic acid, or 2-propylvaleric acid) was first synthesized in 1882, by Burton [1], but there was no known clinical use until its anticonvulsant activity was fo作者: fatty-streak 時(shí)間: 2025-3-25 09:08 作者: Horizon 時(shí)間: 2025-3-25 15:34 作者: 紡織品 時(shí)間: 2025-3-25 16:54
Absorption, distribution, and excretionor heterocyclic anticonvulsants. The pharmacokinetics of valproate have been the subject of regular reviews over the two decades of valproate’s usage as an anticonvulsant [1–4]. This chapter provides a summary of the salient features of the pharmacokinetics of valproate, and additionally, perspectiv作者: 平靜生活 時(shí)間: 2025-3-25 20:04
Toxicitylar disorders [2] or as an adjunct therapeutic for alcohol addiction during withdrawal periods [3]. Other indications for this drug are under investigation like the treatment of intractable hiccups [4] and as an anti-emetic in chemotherapy [5]. The side-effects caused by this important drug will the作者: 友好 時(shí)間: 2025-3-26 00:08
Treatment of epilepsies in adults]. Clinical trials by Carraz et al. [3] followed the initial animal studies that showed efficacy against seizures caused by both pentylenetetrazol and maximal electroshock. Valproic acid was used to treat seizures in Europe almost 15 years before approval in the USA [4]. This drug was used initially作者: 痛苦一下 時(shí)間: 2025-3-26 06:19
Valproate use in psychiatry: A focus on bipolar illness affective illness. Early studies in France by Lambert and in Germany by Emrich presaged the widespread use of the drug in the 1990s [1, 2]. However, it was not until the publication of a series of double-blind controlled studies comparing valproate with lithium and placebo in the early 1990s that i作者: Fsh238 時(shí)間: 2025-3-26 10:23 作者: 厭惡 時(shí)間: 2025-3-26 15:15
Adverse effects and interactions with other drugs1960s when few clinical trials were required, and those performed have simply used incidence reporting following passive inquiry. The prevalence and incidence of adverse effects has not been reported at different points during these early trials and, apart from withdrawal from the trial, no quantifi作者: aggrieve 時(shí)間: 2025-3-26 18:01
The future of valproatessed elsewhere in this volume, but the future of VPA is unknown because it depends on whether safer and more effective medications become available for these conditions. Nevertheless, in this chapter we speculate on the future of VPA based on the current knowledge of its properties and use.作者: ascetic 時(shí)間: 2025-3-27 00:49 作者: Calibrate 時(shí)間: 2025-3-27 04:53
2296-6056 rug against several types of epileptic seizures. Clinical experience with valpro- ate has continued to grow in recent years, including use of valproate for diseases other than epilepsy, for example in bipolar disorders and migraine. In this volume on valproate emphasis is placed on the scientific ba作者: 聯(lián)合 時(shí)間: 2025-3-27 06:06 作者: 去掉 時(shí)間: 2025-3-27 11:30 作者: inhumane 時(shí)間: 2025-3-27 16:50 作者: aquatic 時(shí)間: 2025-3-27 19:35 作者: CANDY 時(shí)間: 2025-3-27 22:13 作者: CLOWN 時(shí)間: 2025-3-28 02:09
Milestones in Drug Therapyhttp://image.papertrans.cn/v/image/980289.jpg作者: 深淵 時(shí)間: 2025-3-28 08:26 作者: 英寸 時(shí)間: 2025-3-28 11:54
Valproate in the treatment of epilepsies in childrenThe treatment of epilepsy with valproate in childhood must take into account the wide range of clinical presentations of epilepsy, including specific responses to the drug, and pharmacological and toxicological particularities in this age range.作者: 性行為放縱者 時(shí)間: 2025-3-28 14:46 作者: Morose 時(shí)間: 2025-3-28 18:59
978-3-0348-9761-7Springer Basel AG 1999作者: FLOAT 時(shí)間: 2025-3-29 00:35
Valproate978-3-0348-8759-5Series ISSN 2296-6056 Series E-ISSN 2296-6064 作者: JEER 時(shí)間: 2025-3-29 05:57
Rainer Emig,Antony Rowlandufficiently high link density, but is detrimental to performance at low link densities or if the quality of the links is degraded. We introduce a new frequency-based method for selecting the most useful citations from a document collection for use in the model.作者: Jingoism 時(shí)間: 2025-3-29 07:55
Washington Soares Ferreira Júnior Ph.D.,Taline Cristina da Silva Ph.D.,Ulysses Paulino Albuquerque Pworks for basic research on families, but also prime examples of their practical use in intervention and policy studies. Contributors also consider the similarities and differences between the study of individuals and the study of family relationships and systems. Included in the coverage:.Use of no作者: 先驅(qū) 時(shí)間: 2025-3-29 13:46 作者: –DOX 時(shí)間: 2025-3-29 16:16
Model-Free Linkage Analysis of a Binary Trait,ages in the study of a complex disease. We introduce the history of model-free linkage analysis in Subheading 1. Table 1 describes a standard model-free linkage analysis workflow. We describe three popular model-free linkage analysis methods, the nonparametric linkage (NPL) statistic, the affected s作者: reflection 時(shí)間: 2025-3-29 23:14
Correction to: Plant Adaptation to Abiotic Stress: From Signaling Pathways and Microbiomes to Molecular Mechanisms,作者: 充滿(mǎn)人 時(shí)間: 2025-3-30 02:56
Afsaneh Gaillard,Frédéric Gaillard,Michel Rogeralopoda, Gastropoda, Bivalvia, Scaphopoda, Polyplacophora, Monoplacophora, Caudofoveata, and Solenogastres. Molluscs are defined by a tissue called the mantle, which forms the shell and encloses most organs. Numerous molluscs also live in . and . .. They are highly diverse, not just in size and . st作者: Concerto 時(shí)間: 2025-3-30 06:27 作者: 試驗(yàn) 時(shí)間: 2025-3-30 10:08
hnique is especially powerful for pharmacokinetic studies of new CNS drug candidates as tissue samples from the brain are understandably difficult to obtain. The PET technique involves the administration of a radiolabeled molecule, often referred to as a PET radiotracer, whose spatiotemporal distrib
