標(biāo)題: Titlebook: Validation of Alternative Methods for Toxicity Testing; Chantra Eskes,Maurice Whelan Book 2016 The Editor(s) (if applicable) and The Autho [打印本頁(yè)] 作者: Harrison 時(shí)間: 2025-3-21 17:36
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書(shū)目名稱(chēng)Validation of Alternative Methods for Toxicity Testing讀者反饋學(xué)科排名
作者: 赤字 時(shí)間: 2025-3-21 20:29
https://doi.org/10.1007/978-3-319-33826-2Computational methods; Human-on-a-chip; In Vitro; Toxicity Testing; Transcriptomics; Validation作者: Demulcent 時(shí)間: 2025-3-22 03:38
978-3-319-81612-8The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl作者: 杠桿支點(diǎn) 時(shí)間: 2025-3-22 05:13 作者: FUSE 時(shí)間: 2025-3-22 09:58
Chantra Eskes,Maurice WhelanPractical insights from experts on current best practice in a fast-evolving field.Insights on current challenges for the validation of novel technologies.An overview of innovative approaches to method作者: resilience 時(shí)間: 2025-3-22 13:04 作者: Strength 時(shí)間: 2025-3-22 18:00 作者: glamor 時(shí)間: 2025-3-22 21:26
Anne Gourmelon,Nathalie Delrueegen way back in 1981 or 1982 at the Delhi campus of the Indian Statistical Institute. As an ap- plied statistician and a consultant in quality control, I was naturally interested in Reliability Theory. I was aquainted with topics in reliability like coherent systems, importance of components etc., 作者: 哀悼 時(shí)間: 2025-3-23 03:41 作者: 依法逮捕 時(shí)間: 2025-3-23 07:38
Sandra Coecke,Camilla Bernasconi,Gerard Bowe,Ann-Charlotte Bostroem,Julien Burton,Thomas Cole,Salvades — not only the altered relationships themselves, but also the political factors which permitted the satellites, with the exception of East Germany, to achieve qualified independence from the Kremlin. The factors varied from country to country; but in each case the trend was toward greater autonom作者: PAEAN 時(shí)間: 2025-3-23 13:01 作者: Morbid 時(shí)間: 2025-3-23 17:32
Rebecca A. Clewell,Patrick D. McMullen,Yeyejide Adeleye,Paul L. Carmichael,Melvin E. Andersenformation networks (HINs). It also covers the research breakthroughs of this area, including models, algorithms and comparison studies in recent years. This SpringerBrief offers a list of promising future research directions of performing CSS over large HINs..The authors first classify the existing 作者: Injunction 時(shí)間: 2025-3-23 18:13
Sebastian Hoffmann,Thomas Hartung,Martin Stephensich the EHP sequences of James and Whitehead were used inductively; “composition methods” were used to construct elements and evaluate homomorphisms. The second was the Adams spectral sequence. Each method has advantages and disadvantages. Toda’s method has the advantage that unstable homotopy group作者: ALIEN 時(shí)間: 2025-3-23 22:14
Raffaella Corvi,Mireia Vilardell,Jiri Aubrecht,Aldert Piersmaodesic flow of lo- cally symmetric spaces of rank one are known also as the generalized Selberg zeta functions. The present book is concerned with these zeta functions from a cohomological point of view. Originally, the Selberg zeta function appeared in the spectral theory of automorphic forms and w作者: 圖畫(huà)文字 時(shí)間: 2025-3-24 03:56
her in 1998. The subject of non-Hermitian Hamiltonian systems possessing real eigenvalues are exploding day by day and combining with almost all other subjects rapidly, in particular, in the areas of quantum optics, lasers and condensed matter systems, where one finds ample successful experiments fo作者: tic-douloureux 時(shí)間: 2025-3-24 08:29 作者: Offbeat 時(shí)間: 2025-3-24 11:57
Claudius Griesinger,Bertrand Desprez,Sandra Coecke,Warren Casey,Valérie Zuangf century of divisions and conflict imposed by the logic of the “cold war”. Enlargement also favours the prospect of increased relations between Europe and its neighbours to the East and to the southern Mediterranean countries. With the further incorporation of Romania and Bulgaria expected to take 作者: 常到 時(shí)間: 2025-3-24 16:37 作者: follicle 時(shí)間: 2025-3-24 19:13 作者: FAST 時(shí)間: 2025-3-24 23:56
Sebastian Hoffmann,Thomas Hartung,Martin Stephensplies that for certain spaces, the unstable homotopy is as accessible as the stable homotopy. It is the purpose of this work to examine how, in certain cases, the methods of Toda can be used for spaces other than spheres. We will begin by summarizing the methods used by Toda. We will discuss the pos作者: evince 時(shí)間: 2025-3-25 03:51 作者: PACK 時(shí)間: 2025-3-25 09:55
Rebecca A. Clewell,Patrick D. McMullen,Yeyejide Adeleye,Paul L. Carmichael,Melvin E. Andersenutions systematically. Specifically, the authors compare different groups of CSMs and analyze both their similarities and differences, from multiple perspective978-3-030-97567-8978-3-030-97568-5Series ISSN 2191-5768 Series E-ISSN 2191-5776 作者: Antagonist 時(shí)間: 2025-3-25 15:10 作者: 引起痛苦 時(shí)間: 2025-3-25 16:07 作者: 相信 時(shí)間: 2025-3-25 22:33 作者: Commodious 時(shí)間: 2025-3-26 03:07 作者: jumble 時(shí)間: 2025-3-26 07:48
Jo?o Barroso,Il Young Ahn,Cristiane Caldeira,Paul L. Carmichael,Warren Casey,Sandra Coecke,Rodger Cu作者: 清澈 時(shí)間: 2025-3-26 10:42 作者: 冷淡周邊 時(shí)間: 2025-3-26 12:56
Introduction,dels derived from induced pluripotent stem cells and significant advances in bioengineering. This chapter provides a historical overview of the establishment and evolution of the principles of the scientific validation of alternative methods for toxicity testing as well as the challenges and opportu作者: 使堅(jiān)硬 時(shí)間: 2025-3-26 18:44
Validation in Support of Internationally Harmonised OECD Test Guidelines for Assessing the Safety otration of relevance will become more challenging for test methods that form part of a set of predictive tools and methods, and that do not stand alone. OECD is keen on ensuring that while these concepts evolve, countries can continue to rely on valid methods and harmonised approaches for an efficie作者: COMA 時(shí)間: 2025-3-26 22:54 作者: 廚師 時(shí)間: 2025-3-27 03:02
Validation of Alternative In Vitro Methods to Animal Testing: Concepts, Challenges, Processes and Td suites, data sources and decision-aiding tools. Data generated with alternative approaches are ultimately used for decision-making on public health and the protection of the environment. It is therefore essential that the underlying methods and methodologies are thoroughly characterised, assessed 作者: 急性 時(shí)間: 2025-3-27 08:00 作者: MITE 時(shí)間: 2025-3-27 11:44 作者: Encumber 時(shí)間: 2025-3-27 15:14
Evidence-Based Toxicology,rivers spurring the development of EBT..In the context of pathway-based toxicology, EBT approaches, given their objectivity, transparency and consistency, have been proposed to be used for carrying out a (retrospective) mechanistic validation..In summary, implementation of more evidence-based approa作者: demote 時(shí)間: 2025-3-27 21:07
Validation of Transcriptomics-Based , Methods,his chapter describes those aspects that were identified as important in the validation process of transcriptomics-based tests, including the assessment of standardisation, reliability and relevance. It also critically discusses the challenges posed to validation in relation to the specific characte作者: FECK 時(shí)間: 2025-3-27 22:21
Ensuring the Quality of Stem Cell-Derived , Models for Toxicity Testing,iative. Accordingly, the chapter summarizes the most up-date best practices in the use and quality control of human Pluripotent Stem Cell lines in the development of . toxicity assays from leading experts in the field.作者: 虛情假意 時(shí)間: 2025-3-28 02:11 作者: 反復(fù)無(wú)常 時(shí)間: 2025-3-28 07:34 作者: 啤酒 時(shí)間: 2025-3-28 13:36 作者: 不如樂(lè)死去 時(shí)間: 2025-3-28 18:25 作者: exophthalmos 時(shí)間: 2025-3-28 20:50 作者: Essential 時(shí)間: 2025-3-29 01:17
Integrated Approaches to Testing and Assessment, models). Decision analytic methods derived from socioeconomic theory can also play a role in developing flexible and optimal IATA solutions. Some of the challenges involved in the development, validation and implementation of IATA are also discussed.作者: minaret 時(shí)間: 2025-3-29 06:51
0065-2598 technologies.An overview of innovative approaches to method.This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing. It covers the validation of experimental and computational methods and integrated approaches to testing作者: 食品室 時(shí)間: 2025-3-29 08:55
Validation of Computational Methods, some of the current difficulties in addressing the residual uncertainties of read-across. Finally we put forward a perspective of how non-testing approaches may evolve in light of the advances in new and emerging technologies and how these fit within the Adverse Outcome Pathway (AOP) framework.作者: AIL 時(shí)間: 2025-3-29 11:49 作者: pacifist 時(shí)間: 2025-3-29 17:55 作者: subacute 時(shí)間: 2025-3-29 23:39
Regulatory Acceptance of Alternative Methods in the Development and Approval of Pharmaceuticals,performing clinical trials in even larger populations, or before marketing authorisation, or to control quality during production. Ethical and animal welfare considerations require that animal use is limited as much as possible. Directive 2010/63/EU on the protection of animals used for scientific p作者: Indigence 時(shí)間: 2025-3-30 02:27 作者: eardrum 時(shí)間: 2025-3-30 07:52 作者: DEAWL 時(shí)間: 2025-3-30 10:58
Validation of Computational Methods,oses. We outline how chemical categories are derived to facilitate endpoint specific read-across using tools such as the OECD QSAR Toolbox and discuss some of the current difficulties in addressing the residual uncertainties of read-across. Finally we put forward a perspective of how non-testing app作者: 鍍金 時(shí)間: 2025-3-30 13:49
Implementation of New Test Methods into Practical Testing,rs are eventually validated for regulatory use. However, for a new test method to be firmly adopted by industry it must be readily available, generally through an in-house industry laboratory, an academic laboratory, or a contract research organization. Regardless of the type of laboratory which int作者: interrupt 時(shí)間: 2025-3-30 18:33 作者: 挑剔為人 時(shí)間: 2025-3-30 23:39
Evidence-Based Toxicology,ell as based on parallels between the evaluation of test methods in toxicology and evidence-based assessment of diagnostics tests in medicine. The role model of evidence-based medicine (EBM) motivated both proposals and guided the evolution of EBT, whereas especially systematic reviews and evidence 作者: 有斑點(diǎn) 時(shí)間: 2025-3-31 04:52
Validation of Transcriptomics-Based , Methods,lar changes underlying the adverse effects of a given compound, but also to understand its Mode of Action (MoA). However, the implementation of transcriptomics-based tests within the regulatory arena is not a straightforward process. One of the major obstacles in their regulatory implementation is s作者: 礦石 時(shí)間: 2025-3-31 06:23
Ensuring the Quality of Stem Cell-Derived , Models for Toxicity Testing,ew drugs or constituents of new consumer products. This chapter explores the key scientific and ethical criteria that must be addressed at the earliest stages of developing toxicology assays based on human pluripotent stem cell (hPSC) lines. It also identifies key considerations for such assays to b作者: 藥物 時(shí)間: 2025-3-31 10:55
Validation of Bioreactor and Human-on-a-Chip Devices for Chemical Safety Assessment, tasks with only a few successful examples so far. The hurdles seem to increase with the growing complexity of the biological systems, emulated by the respective models. Controlled single tissue or organ culture in bioreactors improves the organ-specific functions and maintains their phenotypic stab作者: EWE 時(shí)間: 2025-3-31 16:02
Integrated Approaches to Testing and Assessment, by toxicity testing methods, thereby serving as flexible and suitable tools for toxicological decision making in the twenty-first century. In addition to traditional . and . testing methods, IATA are increasingly incorporating newly developed . systems and measurement technologies such as high thro
