標(biāo)題: Titlebook: V(D)J Recombination; Pierre Ferrier Book 2009 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science [打印本頁] 作者: 推翻 時間: 2025-3-21 20:09
書目名稱V(D)J Recombination影響因子(影響力)
書目名稱V(D)J Recombination影響因子(影響力)學(xué)科排名
書目名稱V(D)J Recombination網(wǎng)絡(luò)公開度
書目名稱V(D)J Recombination網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱V(D)J Recombination被引頻次
書目名稱V(D)J Recombination被引頻次學(xué)科排名
書目名稱V(D)J Recombination年度引用
書目名稱V(D)J Recombination年度引用學(xué)科排名
書目名稱V(D)J Recombination讀者反饋
書目名稱V(D)J Recombination讀者反饋學(xué)科排名
作者: cylinder 時間: 2025-3-21 23:17 作者: CESS 時間: 2025-3-22 02:44
Daniel J. Bolland,Andrew L. Wood,Anne E. Corcoransition the New theory the paper first gives a short presentation of the traditional communication theory. Then there is a short presentation of the paradigm including the research strategy used for the development of the New theory. Following that you will find a section concerning the conceptual fr作者: 爆米花 時間: 2025-3-22 06:57 作者: Minikin 時間: 2025-3-22 09:21
Evelyne Jouvin-Marche,Patrizia Fuschiotti,Patrice No?l Marcheon K?ln, sowie das Sommerresidenzschloss in dem nahen Poppelsdorf überwiesen. Hier fanden insbesondere die zoologischen, mineralogischen und botanischen Sammlungen und Institute ihren Platz; der das Geb?ude umziehende, damals auf allen vier Seiten durch einen Weiher gegen die Strasse hin abgegrenzte作者: 捕鯨魚叉 時間: 2025-3-22 15:27
Iratxe Abarrategui,Michael S. Krangeleilweise eine Bereicherung seines neurologischen Erfahrungsschatzes gewonnen haben, teilweise werden ihn einige unserer Hypothesen und Deutungen zum Widerspruch herausgefordert haben. Dieser Widerspruch wird ihn anregen, sein eigenes Krankengut kritisch zu sichten und die Ergebnisse zur Darstellung 作者: pacific 時間: 2025-3-22 19:40
Mary Elizabeth Jones,Yuan Zhuangtion to the computer. This approach is illustrated in Figure .. .Starting from the original problem, traditional programming results in an executable computer program. On the contrary, . aims at creating a formal . of the original problem. Instead of merely executing a resulting computer program, th作者: AGOG 時間: 2025-3-22 21:55
Sa?da Dadi,Sandrine Le Noir,Vahid Asnafi,Khe?ra Beldjord,Elizabeth A. Macintyreerungsgruppen zu verbessern (Sondermann 2020). Derartige Bestrebungen werden als ?konstituierend für die Herausbildung internationaler Gesundheits-kooperation“ angesehen (ebd.). Durch die Zunahme an Akteuren und grenzüberschreitenden Bedrohungen sowie die daraus resultierenden Herausforderungen für 作者: Dendritic-Cells 時間: 2025-3-23 02:00 作者: –scent 時間: 2025-3-23 06:12
Vicky L. Brandt,David B. Rothserls genetische Ph?nomenologie in Erfahrung und Urteil den methodischen Hintergrund bildet. Es bietet au?erdem eine neue und umfassende Lektüre von Husserls Schriften zur Ethik, sowie einen kritischen Dialog mit der Alterit?tsethik von Levinas und der Diskursethik Apels...?..Anspruch und Rechtferti作者: 外觀 時間: 2025-3-23 11:18 作者: entail 時間: 2025-3-23 14:43
Large-Scale Chromatin Remodeling at the Immunoglobulin Heavy Chain Locus: A Paradigm for Multigene rge loci must be kept closed in lymphocytes in which they do not normally recombine, to guard against genomic instability generated by the DNA double strand breaks inherent to the V(D)J recombination process. To manage all of these demanding criteria, V(D)J recombination is regulated at numerous lev作者: 謙卑 時間: 2025-3-23 18:43
Genetic and Epigenetic Control of V Gene Rearrangement Frequency,ipitation (ChIP) suggests that differences in the structure of the chromatin associated with each gene is also a major factor in differential accessibility for rearrangement. Finally, transcription factors can direct accessibility for recombination, possibly by recruiting chromatin-modifying enzymes作者: 入伍儀式 時間: 2025-3-24 00:37
,Dynamic Aspects of TCRα Gene Recombination: Qualitative and Quantitative Assessments of the TCRα Ch the combinatorial diversity of the TCRα chain repertoire. The recombination profile is compatible with a sequential opening of the V region with progressive tracking along the two regions in opposite directions starting from the nearest and then moving towards the most distant V and J gene segments作者: Inordinate 時間: 2025-3-24 05:25 作者: conspicuous 時間: 2025-3-24 07:56
Normal and Pathological V(D)J Recombination: Contribution to the Understanding of Human Lymphoid Maf clonal evolution. Ig/TCR VDJ errors are also at the origin of recombinase mediated deregulated expression of a variety of proto-oncogenes in ALL, whereas in lymphoma it is increasingly clear that IgH containing translocations result from abnormalities other than VDJ errors (somatic hypermutation a作者: 或者發(fā)神韻 時間: 2025-3-24 14:04 作者: fallible 時間: 2025-3-24 17:13
ecisely cleave and rearrange their antigen receptor (Ig andTCR)loci. This invader would itself have assigned the services of the nonhomologous end joining (NHEJ) DNArepair machinery as well as various DNApolymerases or transferases to work in concert with developmental clues in lymphoid cell lineages to gener978-1-4939-0124-1978-1-4419-0296-2作者: 波動 時間: 2025-3-24 23:01 作者: infinite 時間: 2025-3-25 01:26
Iratxe Abarrategui,Michael S. Krangeligung über die dieser Arbeit gewidmeten Lebensjahre auszudriicken und den leitenden Stellen un serer vorgesetzten Beh?rden fiir die stete Forderung unserer Arbeit zum Wohl der Nervenkranken herzlichen Dank zu sagen.作者: 豐滿有漂亮 時間: 2025-3-25 05:22
V(D)J Recombination Deficiencies,strand breaks (dsb), whether they occur during V(D)J recombination or secondary to other DNA injuries. Two NHEJ factors, . and ., were indeed discovered through the study of human V(D)J recombination defective human SCID patients.作者: 協(xié)奏曲 時間: 2025-3-25 10:29 作者: 把手 時間: 2025-3-25 12:33
Regulation of V(D)J Recombination by E-Protein Transcription Factors,cells undergo recombination. E-proteins appear to be master regulators that coordinate antigen receptor gene rearrangement and expression. This chapter focuses on how E-proteins regulate V(D)J recombination by activating transcription, initiating rearrangement and driving differentiation during B- and T-cell development.作者: 眨眼 時間: 2025-3-25 17:08
Temporal and Spatial Regulation of V(D)J Recombination: Interactions of Extrinsic Factors with the lex consisting of RAG-1 and RAG-2 subunits—and macromolecular assemblies extrinsic to the recombinase. This chapter will focus on those features of the recombinase itself—and in particular the RAG-2 subunit— that interact with extrinsic factors to establish patterns of temporal control and locus specificity in developing lymphocytes.作者: 小步舞 時間: 2025-3-25 20:45
Daniel J. Bolland,Andrew L. Wood,Anne E. Corcoranamework used for the analysis of the companies. This section is followed by a discussion of the main results and the new communication and projection theory. The paper ends with a short discussion of implications for management.作者: Induction 時間: 2025-3-26 02:40 作者: 宏偉 時間: 2025-3-26 08:23 作者: endarterectomy 時間: 2025-3-26 08:59
Regulation of RAG Transposition,es on the mechanism and regulation of RAG transposition. We first provide a brief overview of the biochemistry of V(D)J recombination. We then discuss the discovery of RAG transposition and present an overview of the RAG transposition pathway. Using this pathway as a framework, we discuss the factors and forces that regulate RAG transposition.作者: Irascible 時間: 2025-3-26 15:03 作者: eardrum 時間: 2025-3-26 20:36
Molecular Pathways and Mechanisms Regulating the Recombination of Immunoglobulin Genes during B-Lymcale chromatin dynamics and localized changes in chromatin structure in regulating the accessibility of Ig loci at specific stages of B-cell development. We review this emergent framework and discuss new experimental approaches that will be needed to explore the underlying molecular mechanisms.作者: Galactogogue 時間: 2025-3-27 00:43
V(D)J Recombination: Of Mice and Sharks, show that this process does not have to be ordered, nor does it need to take place in two stages to generate a diverse repertoire and enable the expression of a single species of antigen receptor per cell, a restriction called allelic exclusion.作者: 單調(diào)女 時間: 2025-3-27 01:14 作者: disparage 時間: 2025-3-27 08:47
Regulation of RAG Transposition, complex can also act as a transposase, inserting the broken DNA molecules generated during V(D)J recombination into an unrelated piece of DNA. This process, termed RAG transposition, can potentially cause insertional mutagenesis, chromosomal translocations and genomic instability. This review focus作者: 厚顏 時間: 2025-3-27 09:33
Recent Insights into the Formation of RAG-Induced Chromosomal Translocations,oplasms, however, it is clear that pathogenesis is initiated by any of a number of recurrent DNA rearrangements. These particular translocations typically place an oncogene under the regulatory control of an Ig or TCR gene promoter, dysregulating cell growth, differentiation, or apoptosis. Given tha作者: 結(jié)合 時間: 2025-3-27 14:28 作者: Genistein 時間: 2025-3-27 19:46
Large-Scale Chromatin Remodeling at the Immunoglobulin Heavy Chain Locus: A Paradigm for Multigene uences required to produce diverse antigen receptor proteins. It is the key role of the adaptive immune response, which must potentially combat millions of different foreign antigens. Most antigen receptor loci have evolved to be extremely large and contain multiple individual V, D and J genes. The 作者: 使成整體 時間: 2025-3-28 01:26 作者: plasma 時間: 2025-3-28 02:38 作者: irreducible 時間: 2025-3-28 07:00
Germline Transcription: A Key Regulator of Accessibility and Recombination,combinase machinery. .-acting transcriptional regulatory elements such as promoters and enhancers play a central role in the control of accessibility in vivo. However, the molecular mechanisms by which these elements influence accessibility are still under investigation. Although accessibility for V作者: 沖擊力 時間: 2025-3-28 10:27
Dynamic Regulation of Antigen Receptor Gene Assembly,oire is generated early in B and T-cell development by the process of V(D)J recombination, which randomly assembles functional immunoglobulin (Ig) and T-cell receptor (TCR) genes from large arrays of DNA segments. Precursor lymphocytes must target then retarget a single V(D)J recombinase enzyme to d作者: 可行 時間: 2025-3-28 15:14 作者: 權(quán)宜之計 時間: 2025-3-28 18:45 作者: pus840 時間: 2025-3-28 23:16
Regulation of V(D)J Recombination by E-Protein Transcription Factors,ulating V(D)J recombination in both B- and T-cells. The study of E-proteins in mammals began with the identification of E2A by its ability to bind immunoglobulin heavy and light chain enhancers. Subsequent analysis has identified numerous roles for E2A and HEB at the immunoglobulin and T-cell recept作者: FUME 時間: 2025-3-29 03:36
Temporal and Spatial Regulation of V(D)J Recombination: Interactions of Extrinsic Factors with the ately responsible for several features peculiar to lymphoid development, including the lineage specificity of antigen receptor assembly, allelic exclusion and receptor editing. In addition, cell cycle phase-dependent regulation of V(D)J recombinase activity ensures that DNA rearrangement is complete作者: 祖先 時間: 2025-3-29 09:58
V(D)J Recombination: Of Mice and Sharks,ymphocytes and T-cell receptors (TCR) in T-lymphocytes. The Ig and TCR diversity is generated by a process called V(D)J recombination, which is initiated by the RAG recombinase. Although RAG activity is very well conserved, the regulated accessibility of the antigen receptor genes to RAG has evolved作者: 背信 時間: 2025-3-29 13:58 作者: gnarled 時間: 2025-3-29 17:47
Book 2009nique function of affording adaptive immunity. Yet, for many-from experienced scientists to trainees-it represents a (rather too) sophisticated process whose true insight is excessively demanding. However, when not simplyconsidered as a private ground for a few aficionados, it can be seen as a way o作者: 是他笨 時間: 2025-3-29 23:14
re their unique function of affording adaptive immunity. Yet, for many-from experienced scientists to trainees-it represents a (rather too) sophisticated process whose true insight is excessively demanding. However, when not simplyconsidered as a private ground for a few aficionados, it can be seen 作者: ODIUM 時間: 2025-3-30 02:55
Evelyne Jouvin-Marche,Patrizia Fuschiotti,Patrice No?l Marcheen Sammlungen und Institute ihren Platz; der das Geb?ude umziehende, damals auf allen vier Seiten durch einen Weiher gegen die Strasse hin abgegrenzte Schlossgarten fand als botanischer Garten geeignetste Verwendung.作者: surmount 時間: 2025-3-30 07:09 作者: Myofibrils 時間: 2025-3-30 12:10 作者: 山羊 時間: 2025-3-30 12:50 作者: 寒冷 時間: 2025-3-30 19:23 作者: CRATE 時間: 2025-3-31 00:35 作者: 極小量 時間: 2025-3-31 04:14 作者: Vulnerary 時間: 2025-3-31 08:59 作者: IVORY 時間: 2025-3-31 10:20 作者: CROW 時間: 2025-3-31 14:13
Lance R. Thomas,Robin Milley Cobb,Eugene M. OltzDie Vereinbarung einer Probezeit entspricht allgemeiner übung. Sie kann nach Dauer und Kündigungsfrist beliebig gestaltet werden. Immerhin mu? sich die Dauer der Probezeit im angemessenen Rahmen halten.作者: parasite 時間: 2025-3-31 20:44 作者: OTHER 時間: 2025-3-31 23:41 作者: 疼死我了 時間: 2025-4-1 02:25
Yun Liu,Li Zhang,Stephen DesiderioThe problem of rewriting queries using views is closely related to the problem of checking for query containment or equivalence. For most classes of problems, containment tests enable simple algorithms to rewrite queries using views. Rewriting queries is one of the techniques that is most often used to answer queries using views.作者: Explosive 時間: 2025-4-1 06:17
