標(biāo)題: Titlebook: Systems Pharmacology and Pharmacodynamics; Donald E. Mager,Holly H.C. Kimko Book 2016 American Association of Pharmaceutical Scientists 20 [打印本頁] 作者: Daidzein 時(shí)間: 2025-3-21 18:15
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作者: chance 時(shí)間: 2025-3-21 22:53
provided by prominent scholars on key texts and all texts a.Fresh translations of key texts, exhaustive coverage from Plato to Kant, and detailed commentary by expert scholars of philosophy add up to make this sourcebook the first and most comprehensive account of the history of the philosophy of m作者: ingestion 時(shí)間: 2025-3-22 03:24
Donald E. Mager,Holly H. C. Kimkoy texts on philosophy of language from antiquity (500BC) to For the first time in English, this anthology offers a comprehensive selection of primary sources in the history of philosophy of language. Beginning with a detailed introduction contextualizing the subject, the editors draw out recurring t作者: analogous 時(shí)間: 2025-3-22 08:23 作者: ABASH 時(shí)間: 2025-3-22 11:42
Saroja Ramanujan,Kapil Gadkar,Ananth Kadambierest to individuals involved in clinical practice as well as research. Understand- ing the multiple domains of functioning, evaluating characteristics of individuals in relation to others (normative assessment) as well as in relation to themselves (ipsative assessment), and charting progress or cha作者: 否認(rèn) 時(shí)間: 2025-3-22 15:12 作者: Melanoma 時(shí)間: 2025-3-22 18:30
Steven Nathaniel Steinway,Rui-Sheng Wang,Reka Alberterest to individuals involved in clinical practice as well as research. Understand- ing the multiple domains of functioning, evaluating characteristics of individuals in relation to others (normative assessment) as well as in relation to themselves (ipsative assessment), and charting progress or cha作者: Patrimony 時(shí)間: 2025-3-23 01:17
Mehdi Bouhaddou,Marc R. Birtwistlerce book or survey of the elements/essentials of feedback control systems. The material included is a result of my development, over a period of several years, of summaries written to supplement a number of standard textbooks for undergraduate and early post-graduate courses. Those notes, plus more 作者: JEER 時(shí)間: 2025-3-23 01:32 作者: VOK 時(shí)間: 2025-3-23 06:35
ist, critical race, and social exchange theories.Addresses s.This sourcebook is an unparalleled resource in the field of family science. It provides a comprehensive overview of both traditional and contemporary theories and methodologies to promote a greater understanding of increasingly complex fam作者: 步履蹣跚 時(shí)間: 2025-3-23 10:35 作者: 星星 時(shí)間: 2025-3-23 17:15
Wojciech Krzyzanski of your brothers or sisters is a standard family practice. In collectivistic cultures with high maternal mortality rates, older siblings, especially sisters, take on a primary caregiver role, aka alloparent (Weisner et al., 1977), or are often designated to be the helpers-at-the-nest, who assist in作者: 太空 時(shí)間: 2025-3-23 18:57 作者: Aesthete 時(shí)間: 2025-3-24 01:55 作者: 污點(diǎn) 時(shí)間: 2025-3-24 02:41
Peter L. Bonate,Amit Desai,Ahsan Rizwan,Zheng Lu,Stacey Tannenbaumtional alternative or supplementary medium of treatment and .As a primary or an adjunct mental health therapy, written practice exercises have proven an effective, low-cost way for clients to transfer gains made in therapy to the challenges of daily life and relationships. These interactive workbook作者: agglomerate 時(shí)間: 2025-3-24 07:14 作者: Juvenile 時(shí)間: 2025-3-24 10:50
e in therapy to the challenges of daily life and relationships. These interactive workbooks expand on earlier self-help and distance writing methods along a continuum of healing approaches, from the proactive and preventive to the therapeutic and rehabilitative. But despite their appeal, large-scale作者: Physiatrist 時(shí)間: 2025-3-24 16:47
Hugo Geerts,Patrick Roberts,Athan Spiros,Robert Carrtional alternative or supplementary medium of treatment and .As a primary or an adjunct mental health therapy, written practice exercises have proven an effective, low-cost way for clients to transfer gains made in therapy to the challenges of daily life and relationships. These interactive workbook作者: 雪崩 時(shí)間: 2025-3-24 19:01
Jeremy D. Scheff,Kubra Kamisoglu,Ioannis P. Androulakistional alternative or supplementary medium of treatment and .As a primary or an adjunct mental health therapy, written practice exercises have proven an effective, low-cost way for clients to transfer gains made in therapy to the challenges of daily life and relationships. These interactive workbook作者: 挑剔小責(zé) 時(shí)間: 2025-3-25 02:38 作者: TOM 時(shí)間: 2025-3-25 03:38
AAPS Advances in the Pharmaceutical Sciences Serieshttp://image.papertrans.cn/t/image/884914.jpg作者: 神圣不可 時(shí)間: 2025-3-25 07:40
https://doi.org/10.1007/978-3-319-44534-2PK/PD; bioinformatics; drug targets; modeling; pharmacokinetics; systems biology作者: 態(tài)學(xué) 時(shí)間: 2025-3-25 13:46 作者: 字形刻痕 時(shí)間: 2025-3-25 16:51 作者: FIN 時(shí)間: 2025-3-25 23:10 作者: brassy 時(shí)間: 2025-3-26 01:07
Book 2016le optimized therapy for each patient. Systems pharmacology is the relatively new discipline?that is the?interface between these two methods. This book is the first to?cover the expertise from systems biology and pharmacodynamics researchers, describing how systems pharmacology may be developed and 作者: 評(píng)論性 時(shí)間: 2025-3-26 05:08
2210-7371 ould reduce the high attrition in the drug development pipelWhile systems biology and pharmacodynamics have evolved in parallel,?there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipli作者: grandiose 時(shí)間: 2025-3-26 11:42 作者: 使入迷 時(shí)間: 2025-3-26 14:08
Multi-scale Modeling of Drug Action in the Nervous Systeml neurosciences to which very specific neuropharmacology processes are added. This chapter illustrates a multi-scale drug action model for CNS diseases. We show various applications of this platform in actual CNS research and development projects.作者: 職業(yè)拳擊手 時(shí)間: 2025-3-26 19:59
Mechanistic Modeling of Inflammationn (mechanistic) disease and pharmacology models as we move towards more integrated systems pharmacology approaches with the ultimate goal of designing relevant in silico clinical trials enabling rational extrapolation of bench observations.作者: liaison 時(shí)間: 2025-3-26 23:33
Systems Pharmacology and Pharmacodynamics: An Introductions of pharmacokinetics and pharmacodynamics (PK/PD). Systems biology encompasses a broad spectrum of computational methods for vertically capturing molecular, cellular, and tissue level interactions that regulate biological systems. In contrast, PK/PD models are often minimal compartmental constructs作者: 泄露 時(shí)間: 2025-3-27 03:21
Role of Systems Modeling in Regulatory Drug Approvalate applications of modeling, simulation, and other innovations in the public health context. FDA continues to target improvements in regulatory science, including the development of scientific tools that can bridge the gap between cutting-edge discoveries and real-world diagnostics and therapeutics作者: 注意到 時(shí)間: 2025-3-27 07:53
Quantitative Systems Pharmacology: Applications and Adoption in Drug Developments in drug development. The ability to integrate diverse data into a unified framework provides a promising approach for a systematic, quantitative evaluation and prediction of the complex interaction between potential therapeutics and biological pathways of disease, with application across the resea作者: groggy 時(shí)間: 2025-3-27 13:21 作者: antecedence 時(shí)間: 2025-3-27 16:24 作者: deface 時(shí)間: 2025-3-27 18:22 作者: 通知 時(shí)間: 2025-3-28 01:48
Mechanistic Models of Physiological Control Systemsrity of models in the literature do not take into account the fact that pharmacological responses are frequently affected by the homeostatic mechanisms inherent in physiological control systems. This article provides a short tutorial presenting examples that illustrate the basic properties of closed作者: Malaise 時(shí)間: 2025-3-28 05:03 作者: 重畫只能放棄 時(shí)間: 2025-3-28 09:37 作者: 手銬 時(shí)間: 2025-3-28 14:22 作者: 可行 時(shí)間: 2025-3-28 17:18
Feedback Control Indirect Response Modelslatory mechanisms are incomplete representations of the drug-response relationship, and may lead to an underestimation of a drug’s potency. In this chapter, a new general framework is introduced for modeling pharmacodynamic processes that are subject to autoregulation, in which the canonical IDR mod作者: Unsaturated-Fat 時(shí)間: 2025-3-28 20:48 作者: prostatitis 時(shí)間: 2025-3-29 01:30
Detecting Pharmacokinetic and Pharmacodynamic Covariates from High-Dimensional Data during pharmacogenetic/genomic clinical trials, there is need for computationally efficient methodologies capable of integrating that information into the drug development pipeline; however, the computational cost of identifying covariates and interactions through traditional parametric statistical作者: 身心疲憊 時(shí)間: 2025-3-29 05:08
Multi-scale Modeling of Drug Action in the Nervous Systemeclinical animal models for diseases like schizophrenia, Alzheimer’s disease, and depression. In addition, treatment of patients in real-life situations is far from perfect, and polypharmacy is attempted without a rational understanding of the interactions of the various drugs with each other and wi作者: 符合國情 時(shí)間: 2025-3-29 10:21 作者: 事情 時(shí)間: 2025-3-29 12:17 作者: Ibd810 時(shí)間: 2025-3-29 17:07 作者: CREST 時(shí)間: 2025-3-29 19:54
Direct, Indirect, and Signal Transduction Response Modelingcs and response. When relevant, alternative parameterizations and parameter identifiability are discussed. Only the simplest forms of models are provided with some guidelines on how to build more complex models based on a systems pharmacology approach.作者: 保守 時(shí)間: 2025-3-30 01:15 作者: 同位素 時(shí)間: 2025-3-30 08:02
Mehdi Bouhaddou,Marc R. Birtwistled of the special characteristics of computers, their programming, and their potential interactions into systems. In particular, students with specializations other than control systems are not being exposed to the breadth of the considerations needed in control systems engineering, perhaps because i作者: employor 時(shí)間: 2025-3-30 09:14
Michael C. K. Khoo,Wen-Hsin Hu,Patjanaporn Chalachevaour reconceptualization of FDT, and second, to highlight four developmental dimensions common across the diverse challenges faced by families—here, those in refugee contexts. For more details about the tenants and propositions of MFDT and how it relates to FDT as presented in this sourcebook, see Cr作者: 漂白 時(shí)間: 2025-3-30 15:44 作者: Hemiplegia 時(shí)間: 2025-3-30 17:18 作者: Compass 時(shí)間: 2025-3-30 23:05
Alberto Russu,Italo Poggesid. All that was really left to do, in our opinion, was to formally recognize the value and the legitimacy of this approach—as had been done systematically with a variety of other theoretical approaches in previous works (Christensen, 1964; Hill and Hansen, 1960; Nye and Berardo, 1966)—and to put it 作者: Malcontent 時(shí)間: 2025-3-31 03:39 作者: oxidant 時(shí)間: 2025-3-31 08:56 作者: Canvas 時(shí)間: 2025-3-31 10:10 作者: rectum 時(shí)間: 2025-3-31 17:09 作者: 錫箔紙 時(shí)間: 2025-3-31 17:59
Role of Systems Modeling in Regulatory Drug Approvalor gene interactions on drug pharmacokinetics and subsequent need for dedicated studies. Published FDA guidance documents related to drug interactions and early phase pharmacogenomic evaluation have included recommendations for the use of PBPK where appropriate. As pharmacology and clinical pharmaco作者: 食物 時(shí)間: 2025-3-31 22:28
Quantitative Systems Pharmacology: Applications and Adoption in Drug Developmentnd success of QSP will require a clearly articulated record of impact on drug development decisions, alongside the development of approaches to address current challenges in the implementation and technical evaluation of such efforts.作者: Modicum 時(shí)間: 2025-4-1 05:37
Systems Pharmacology: An Overview modules regulating the cellular state. Dynamic modeling and sensitivity analysis allow the identification of robust and fragile nodes within these modules to identify putative drug targets for single or combinatorial drug treatment. Traditional pharmacokinetic and pharmacodynamic modeling complemen
