標(biāo)題: Titlebook: Sigma Proteins: Evolution of the Concept of Sigma Receptors; Felix J. Kim,Gavril W. Pasternak Book 2017 Springer International Publishing [打印本頁] 作者: 人工合成 時間: 2025-3-21 18:48
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書目名稱Sigma Proteins: Evolution of the Concept of Sigma Receptors讀者反饋學(xué)科排名
作者: indifferent 時間: 2025-3-21 20:21
Felix J. Kimtory. Since decisions involving migration can change the course of people‘s lives, it is imperative to verify the neutrality of the algorithms used. This chapter analyses how AI has been applied to the decision-making process regarding migration, mainly evaluating whether AI violates international p作者: Bombast 時間: 2025-3-22 03:28 作者: BUDGE 時間: 2025-3-22 05:34
Erik Laurini,Domenico Marson,Maurizio Fermeglia,Sabrina Pricltheoretical objective consists of searching for the most important areas of intersection between copyright and culture, including cultural production and participation. The empirical objective is to reconstruct understandings of the interrelations between copyright law and culture functioning within作者: Fissure 時間: 2025-3-22 12:20
Frauke Weber,Bernhard Wünsch that concern the relationships between law & culture.Introd.Divided into three parts, this book examines the relationship between law and culture from various perspectives, both theoretical and empirical. Part I outlines the framework for further considerations and includes new, innovative conceptu作者: Charlatan 時間: 2025-3-22 14:11 作者: 不愿 時間: 2025-3-22 17:21
Sa?d Kourrichnd a wide scope of a party’s impact on the course of a trial. However, its appearance is not limited to any particular legal system. The subject of this chapter is a case study of a court case in which arguments based on cultural defense were raised in particular conditions—within the Polish legal s作者: 朋黨派系 時間: 2025-3-22 22:36 作者: Encumber 時間: 2025-3-23 01:31 作者: 激怒 時間: 2025-3-23 06:48 作者: 存在主義 時間: 2025-3-23 10:44 作者: Dedication 時間: 2025-3-23 14:12
Handbook of Experimental Pharmacologyhttp://image.papertrans.cn/s/image/867036.jpg作者: 警告 時間: 2025-3-23 20:52
https://doi.org/10.1007/978-3-319-65853-7Chaperone; Neurodegenerative disease; Pain; Pathophysiology; Protein homeostasis; Scaffold作者: 使閉塞 時間: 2025-3-24 01:01
Felix J. Kim,Gavril W. PasternakProvides an updated perspective on this rapidly evolving field undergoing changes in fundamental concepts of key importance to the discipline of pharmacology.Emphasis is laid on the roles of sigma pro作者: Interdict 時間: 2025-3-24 04:30
978-3-319-88116-4Springer International Publishing AG, part of Springer Nature 2017作者: 共和國 時間: 2025-3-24 09:12
Sigma Proteins: Evolution of the Concept of Sigma Receptors978-3-319-65853-7Series ISSN 0171-2004 Series E-ISSN 1865-0325 作者: custody 時間: 2025-3-24 11:46
,Sigma-1 (σ1) Receptor in Memory and Neurodegenerative Diseases,athogenesis. Here, we will review genetic and pharmacological evidence of σ. receptor engagement in learning and memory disorders, cognitive impairment, and neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, and Huntington’s disease.作者: 娘娘腔 時間: 2025-3-24 16:09
Sigma-1 Receptor and Neuronal Excitability, will describe and discuss the latest findings on Sig-1R-dependent modulation of VGICs and LGICs, and provide hypotheses that may explain the diverse excitability outcomes that have been reported so far.作者: PET-scan 時間: 2025-3-24 21:04
Allosteric Modulation of Opioid G-Protein Coupled Receptors by Sigma1 Receptors,ors can physically associate with GPCRs. Together, these findings show that sigma. ligands can function as allosteric modulators of GPCR function through their association with the sigma. receptors, which are in direct physical association with opioid receptors, members of the G-protein coupled family of receptors.作者: Expertise 時間: 2025-3-25 01:11 作者: Range-Of-Motion 時間: 2025-3-25 06:56
Sigma Receptors and Alcohol Use Disorders,and it was suggested that their hyperactivity may result in excessive alcohol drinking. This chapter reviews current knowledge on the topic, and suggests that the sigma receptor system may represent a new therapeutic target for the treatment of alcohol use disorders.作者: Latency 時間: 2025-3-25 07:51 作者: conservative 時間: 2025-3-25 13:37
3D Homology Model of Sigma1 Receptor,ation of the virtual 3D Sigma1 receptor model and its reliable applicability to docking-based virtual screening is of significance for rational ligand design, even in light of the recently reported crystal structure for the Sigma1 receptor.作者: 六邊形 時間: 2025-3-25 15:53
Introduction to Sigma Proteins: Evolution of the Concept of Sigma Receptors,uously and significantly evolved. With thousands of publications on the subject, these proteins have been implicated in various diseases, disorders, and physiological processes. Nevertheless, we are just beginning to understand what sigma proteins do and how they work. Two subtypes have been identif作者: 松緊帶 時間: 2025-3-25 21:18 作者: Control-Group 時間: 2025-3-26 03:45
3D Homology Model of Sigma1 Receptor,cability of this structure to docking-based virtual screening and discuss combined in silico/in vitro mutagenesis studies performed to validate the structural features of the Sigma1 receptor model and to qualify/quantify the prominent role of specific amino acid residues in ligand binding. The valid作者: Picks-Disease 時間: 2025-3-26 07:40
,Medicinal Chemistry of σ1 Receptor Ligands: Pharmacophore Models, Synthesis, Structure Affinity Reled by two hydrophobic regions, representing the pharmacophoric elements. The development of computer-based models like the 3D homology model is described as well as the first crystal structure of the σ. receptor. The second part focuses on the synthesis and biological properties of different σ. rece作者: 發(fā)酵劑 時間: 2025-3-26 11:26
,Sigma-1 (σ1) Receptor in Memory and Neurodegenerative Diseases,le communication, in part through its chaperone activity. In vivo, agonists of the σ. receptor enhance brain plasticity, with particularly well-described impact on learning and memory. Under pathological conditions, σ. receptor agonists can induce cytoprotective responses. These protective responses作者: 合唱隊 時間: 2025-3-26 13:35
Sigma-1 Receptor and Neuronal Excitability,lved in a plethora of neuronal functions. This capability to regulate a variety of ion channel targets endows the Sig-1R with a powerful capability to fine tune neuronal excitability, and thereby the transmission of information within brain circuits. This versatility may also explain why the Sig-1R 作者: 寒冷 時間: 2025-3-26 18:53
Sigma-1 Receptor and Pain,nd/or reduce their unwanted effects. Current preclinical evidence supports the modulatory role of the sigma-1 receptor (σ.R) in nociception, mainly based on the pain-attenuated phenotype of σ.R knockout mice and on the antinociceptive effect exerted by σ.R antagonists on pain of different etiology, 作者: ARBOR 時間: 2025-3-27 00:59
Allosteric Modulation of Opioid G-Protein Coupled Receptors by Sigma1 Receptors,amily, molecular studies have now identified its genes and established its structure crystallographically. Much effort has now revealed its importance as a chaperone in the endoplasmic reticulum, but its functions extend beyond this. Sigma. receptors have been associated with a host of signaling sys作者: 量被毀壞 時間: 2025-3-27 02:44
A Role for Sigma Receptors in Stimulant Self-Administration and Addiction,rs of psychomotor stimulant effects and have at times been proposed as potential avenues for modifying stimulant abuse. However, the influence of ligands for σRs on the effects of stimulants, such as cocaine or methamphetamine, in various preclinical procedures related to drug abuse has been varied.作者: 做事過頭 時間: 2025-3-27 06:59 作者: 富饒 時間: 2025-3-27 13:09
Sigma1 Pharmacology in the Context of Cancer,. The majority of publications on the subject have focused on the neuropharmacology of Sigma1. However, a number of publications have also suggested a role for Sigma1 in cancer. Although there is currently no clinically used anti-cancer drug that targets Sigma1, a growing body of evidence supports t作者: rheumatology 時間: 2025-3-27 16:52
Molecular Probes for Imaging the Sigma-2 Receptor: In Vitro and In Vivo Imaging Studies,y and high selectivity for σ. receptors have the potential to assess the proliferative status of human tumors using noninvasive imaging techniques such as Positron Emission Tomography (PET). Since the σ. receptor has not been cloned, the current knowledge of this receptor has relied on receptor bind作者: Mendicant 時間: 2025-3-27 20:05 作者: 駁船 時間: 2025-3-27 22:02
Introduction to Sigma Proteins: Evolution of the Concept of Sigma Receptors,ite the large number of publications regarding Sigma1, several fundamental questions remain unanswered or only partially answered. Most of what we know about Sigma1 comes from pharmacological studies; however, a clearly defined molecular mechanism of action remains elusive. One concept has become cl作者: 離開可分裂 時間: 2025-3-28 02:13 作者: 思想靈活 時間: 2025-3-28 07:39 作者: prostatitis 時間: 2025-3-28 11:46 作者: 竊喜 時間: 2025-3-28 15:52 作者: MURAL 時間: 2025-3-28 20:52 作者: 冰雹 時間: 2025-3-29 02:37 作者: 財主 時間: 2025-3-29 03:56
ty regime. Complementing the doctrinal analysis, this chapter employs a law and economics analysis, which showcases that the accountability gap is a serious challenge also from a consequentialist point of view. Lastly, this chapter proposes a few legal alternatives that depart from the incumbent con作者: laparoscopy 時間: 2025-3-29 10:29
Felix J. Kim. Possible solutions that might help these systems provide equal treatment to migrants consist of greater transparency regarding the variables used in training. Consistent evaluations of methods and performance, to detect and remove biases emerging from historical data or structural inequity might a作者: PATHY 時間: 2025-3-29 14:30
Andrew KruseR’s effectiveness in fighting VAT fraud would be reduced if the algorithms that it uses were publicly known, it is questionable whether STIR complies with the principle of proportionality and the right to explanation, both of which are mandated under the EU data protection regulation and human right作者: 西瓜 時間: 2025-3-29 16:01 作者: 遺傳 時間: 2025-3-29 21:25 作者: eulogize 時間: 2025-3-30 00:19
Tangui Maurice,Nino Goguadzed consideration of the issue of admissibility of invocation of cultural defense in particular institutional and formal settings. It also depicted necessity of adaptation of the framework of the case study in reference to court case as a particular subject of research.作者: FLING 時間: 2025-3-30 04:40
