標題: Titlebook: Retinal Degenerative Diseases; Mechanisms and Exper John D. Ash,Robert E. Anderson,Christian Grimm Conference proceedings 2018 Springer Int [打印本頁] 作者: crusade 時間: 2025-3-21 16:12
書目名稱Retinal Degenerative Diseases影響因子(影響力)
書目名稱Retinal Degenerative Diseases影響因子(影響力)學科排名
書目名稱Retinal Degenerative Diseases網(wǎng)絡公開度
書目名稱Retinal Degenerative Diseases網(wǎng)絡公開度學科排名
書目名稱Retinal Degenerative Diseases被引頻次
書目名稱Retinal Degenerative Diseases被引頻次學科排名
書目名稱Retinal Degenerative Diseases年度引用
書目名稱Retinal Degenerative Diseases年度引用學科排名
書目名稱Retinal Degenerative Diseases讀者反饋
書目名稱Retinal Degenerative Diseases讀者反饋學科排名
作者: corpuscle 時間: 2025-3-21 22:02 作者: 人造 時間: 2025-3-22 02:53 作者: 抒情短詩 時間: 2025-3-22 07:12
Advances in Experimental Medicine and Biologyhttp://image.papertrans.cn/r/image/829208.jpg作者: 死亡率 時間: 2025-3-22 12:37 作者: 疲勞 時間: 2025-3-22 13:48
MicroRNA as Therapeutics for Age-Related Macular DegenerationXu .), relatively little research has been conducted into the therapeutic potential of miRNAs for the treatment of AMD. This review will investigate the use of miRNAs as therapeutic and diagnostic molecules for AMD.作者: commute 時間: 2025-3-22 19:50
Co-Expression of Wild-Type and Mutant S163R C1QTNF5 in Retinal Pigment Epitheliumivered subretinally to mouse RPE cells, the mutant impairs the wild-type protein secretion from the RPE, and both proteins are dispersed toward the basal and lateral RPE membrane. This result has mechanistic and therapeutic implications for L-ORD disorder.作者: Macronutrients 時間: 2025-3-23 00:08 作者: 吸氣 時間: 2025-3-23 02:41
Antisense Oligonucleotide-Based Splice Correction of a Deep-Intronic Mutation in , Underlying Choroi intronic mutation in . underlying Leber congenital amaurosis. Here, we expand the use of these therapeutic molecules for the c.315-4587T>A deep-intronic mutation in . by demonstrating splice correction in patient-derived lymphoblast cells.作者: archetype 時間: 2025-3-23 08:25 作者: 單片眼鏡 時間: 2025-3-23 11:10 作者: FLAIL 時間: 2025-3-23 14:42 作者: 上坡 時間: 2025-3-23 18:48
Toll-Like Receptors and Age-Related Macular Degeneration implicated in disease progression, but while polymorphisms in genes associated with the immune system have been identified as risk factors for disease, the underlying pathways and mechanisms involved in disease progression remain incompletely characterised. Typically inflammatory responses are medi作者: capsule 時間: 2025-3-24 02:08
Alterations in Extracellular Matrix/Bruch’s Membrane Can Cause the Activation of the Alternative Comrtunately, the design of therapies for early stages of the disease is limited by our understanding of the mechanisms involved in the formation of basal deposits and drusen, the first clinical signs of AMD. During the last decade, the identification of common and rare alleles in complement genes as r作者: 痛苦一下 時間: 2025-3-24 04:01
MicroRNA as Therapeutics for Age-Related Macular Degenerationne expression. While miRNAs were only identified in humans as recently as the turn of this century, some miRNA-based agents are already in Phase 2 clinical trials (Christopher et al. .). This rapid progress from initial discovery to drug development reflects the effectiveness of miRNAs as therapeuti作者: 過份 時間: 2025-3-24 09:49
Anaphylatoxin Signaling in Retinal Pigment and Choroidal Endothelial Cells: Characteristics and Releh an increased risk for AMD, and it has been hypothesized that an overactive complement system is partially responsible for the pathology of AMD. AMD is classified as early, intermediate, or late AMD, depending on the degree of the associated pathologies. Late AMD can be characterized as either lesi作者: DEI 時間: 2025-3-24 13:47 作者: enormous 時間: 2025-3-24 15:25
Co-Expression of Wild-Type and Mutant S163R C1QTNF5 in Retinal Pigment Epitheliumresence of thick extracellular sub-RPE deposits, similar histopathologically to those found in AMD patients. We have previously shown that the S163R C1QTNF5 mutant forms globular aggregates within the RPE in vivo following its AAV-mediated expression in the RPE and exhibits a reversely polarized dis作者: embolus 時間: 2025-3-24 19:11 作者: 隨意 時間: 2025-3-25 02:08
Mutation-Independent Gene Therapies for Rod-Cone Dystrophiesns using adeno-associated virus (AAV) as viral vector. However, inherited retinal degenerative diseases showcase a broad genetic and mechanistic heterogeneity, challenging the development of mutation-specific therapies for each specific mutation. Mutation-independent approaches must be developed to 作者: LIMN 時間: 2025-3-25 07:02 作者: 宏偉 時間: 2025-3-25 07:45
Gene Therapy Approaches to Treat the Neurodegeneration and Visual Failure in Neuronal Ceroid Lipofusren. Symptoms include vision loss, seizures, motor deterioration and cognitive decline ultimately resulting in premature death. Studies in animal models showed that the diseases are amenable to gene supplementation therapies, and over the last decade, major advances have been made in the (pre)clinic作者: 逃避責任 時間: 2025-3-25 14:34 作者: 序曲 時間: 2025-3-25 16:54
Optimizing Non-viral Gene Therapy Vectors for Delivery to Photoreceptors and Retinal Pigment Epithells of transgenes have not met the requirements for successful clinical applications so far. The biggest advantage of polymer-based nanoparticle vectors is the ease with which they can be modified to increase their ability to penetrate the cell membrane and target specific cells by simply changing th作者: 鳴叫 時間: 2025-3-25 22:22 作者: 印第安人 時間: 2025-3-26 03:42 作者: CRUDE 時間: 2025-3-26 07:35 作者: 四海為家的人 時間: 2025-3-26 09:35
Success of Gene Therapy in Late-Stage Treatmentdvanced disease stage and analyzed the rescue. We showed stable, sustained rescue of photoreceptor structure and function for at least 1?year, demonstrating gene therapy efficacy after onset of degeneration. The results suggest that RP patients are treatable, even when the therapy is administered at late disease stages.作者: commune 時間: 2025-3-26 15:43 作者: gratify 時間: 2025-3-26 20:28 作者: oxidize 時間: 2025-3-26 22:15 作者: epicondylitis 時間: 2025-3-27 04:32 作者: 把…比做 時間: 2025-3-27 07:35 作者: 殖民地 時間: 2025-3-27 12:39
Masaki Tanito,Ichiya Sano,Tsutomu Okuno,Yoshihisa Ishiba,Akihiro Ohiraing Library during the Columbian Exposition of 1893. The chapter examines what Aliye’s books potentially symbolized and conceptualized to the Fair audience, the organizers of the Woman’s Building, other American women who spoke at the Fair about the Ottoman and/or Muslim women, and to the Muslim aud作者: ARCH 時間: 2025-3-27 14:13 作者: 使隔離 時間: 2025-3-27 20:10 作者: obstruct 時間: 2025-3-28 01:49 作者: Matrimony 時間: 2025-3-28 06:07
Rahel Zulliger,Jamie N. Watson,Muayyad R. Al-Ubaidi,Linas Padegimas,Ozge Sesenoglu-Laird,Mark J. Cooe. In addition, a steep terrain with short rivers and narrow watersheds result in a quick runoff to the sea. The fact that this precipitation cannot be used effectively as water resources is a major distinguishing characteristic. Evaluation of warming effects based on historical weather and hydrolog作者: 幸福愉悅感 時間: 2025-3-28 06:16
Fan Yang,Hongwei Ma,Sanford L. Boye,William W. Hauswirth,Xi-Qin Dingf energy and, not differently from most countries, is experiencing difficulty complying with the targets agreed in the Kyoto Protocol. A vociferous Green Party (.) has been active in Italy for almost 25 years, but until recently Italy, compared to other Western countries, had not developed many effe作者: ARCH 時間: 2025-3-28 13:47
ditions. As indicated in Figure 6.1, the number of dead or missing as a result of natural disasters exceeded 1000 almost every year because of successive big typhoons and earthquakes from the end of the Second World War to the 1959 Ise-wan typhoon, which caused the greatest flood damage with over 50作者: BRINK 時間: 2025-3-28 16:53
0065-2598 nces in these areas of retinal degenerations will be described, there will be many new topics that either were in their infancy or did not exist at the time of the last RD Symposium, RD2014.?These include the r978-3-030-09221-4978-3-319-75402-4Series ISSN 0065-2598 Series E-ISSN 2214-8019 作者: Mercurial 時間: 2025-3-28 21:15 作者: 責問 時間: 2025-3-29 02:06
B?rbel Rohrerinists and the content sent to Chicago. Across the categories of literature, domestic arts, “feminist works,” children’s literature, Norwegian language, nostalgia, and religion, the authors’ barrier-breaking work toward gender equality is revealed, despite the boundaries that restricted them during 作者: 背帶 時間: 2025-3-29 05:38
Masaki Tanito,Ichiya Sano,Tsutomu Okuno,Yoshihisa Ishiba,Akihiro Ohiramonstrates the diversity of women’s activism beyond Western feminism. Aliye’s works not only pioneer contemporary Islamic feminist movements that deconstruct patriarchal exegesis and argue for gender equality based on Islamic doctrine but also introduce a criticism of Orientalist portrayals of Musli作者: VEN 時間: 2025-3-29 09:23 作者: Obedient 時間: 2025-3-29 15:03 作者: 大約冬季 時間: 2025-3-29 17:31 作者: 過去分詞 時間: 2025-3-29 20:21
Rahel Zulliger,Jamie N. Watson,Muayyad R. Al-Ubaidi,Linas Padegimas,Ozge Sesenoglu-Laird,Mark J. Cooease in precipitation coupled with a 3°C rise in temperature does little to reduce flows in water-scarce areas but increases flows by roughly 15% in water-abundant areas. (3) A temperature rise turns snowfall to rain and accelerates snow melting, increasing flows from January through March and decre作者: blight 時間: 2025-3-30 00:42
Fan Yang,Hongwei Ma,Sanford L. Boye,William W. Hauswirth,Xi-Qin Dingi government was able to express its willingness to build new nuclear plants. One of the issues now debated is if ‘going nuclear’ is not just a cheaper way to produce energy, but also the only realistic option to reduce emissions of CO. without endangering economic development.作者: 莎草 時間: 2025-3-30 06:48 作者: browbeat 時間: 2025-3-30 08:26 作者: Mystic 時間: 2025-3-30 15:52
Sophia-Martha kleine Holthaus,Alexander J. Smith,Sara E. Mole,Robin R. Ali作者: Aspirin 時間: 2025-3-30 17:43
Mitochondria: Potential Targets for Protection in Age-Related Macular Degenerationcan lead to the chronic oxidative stress associated with the disease. Therefore, one protective strategy may involve the use of small molecule therapies that target the regulation of mitochondrial biogenesis and mitochondrial fission and mitophagy.作者: JOG 時間: 2025-3-30 22:25
Toll-Like Receptors and Age-Related Macular Degenerationof membrane-spanning PRRs for which host-derived ligands have been identified; these include heat shock proteins, extracellular matrix breakdown products, mRNA from necrotic cells and modified lipids. Here we review the evidence for TLR involvement in the pathogenesis of AMD.作者: 彩色 時間: 2025-3-31 03:23
Alterations in Extracellular Matrix/Bruch’s Membrane Can Cause the Activation of the Alternative ComE)/Bruch’s membrane (BrM), which favors the anchoring of complement C3b generated by convertase-independent cleavage of C3 via tick-over and produces a chronic activation of the alternative complement pathway.作者: Throttle 時間: 2025-3-31 06:45 作者: jaunty 時間: 2025-3-31 11:56
Estimations of Retinal Blue-Light Irradiance Values and Melatonin Suppression Indices Through Clear r the +10-D, +20-D, and +30-D ZCB00V IOLs, respectively; 1.03 for phakic eyes; and 1.21 for aphakic eyes. The data from the six clear IOLs (SA60AT, Alcon Japan; VA-60BBR, Hoya; AU6?K, Kowa, N4-18B, Nidek; X-60, Santen; KS-3Ai, Staar Japan) and seven yellow-tinted IOLs (SN60AT; YA-60BBR, Hoya; AU6N, 作者: 天氣 時間: 2025-3-31 15:46
Mini-Review: Cell Type-Specific Optogenetic Vision Restoration Approachesich is indicated by clinical studies with epiretinal implants, where patients can perform simple visual tasks. Finally, optogenetics in combination with neuroprotective approaches could serve as a valuable strategy to restore the function of remaining cells, as well as to rescue retinal neurons from作者: adj憂郁的 時間: 2025-3-31 20:22
Optimizing Non-viral Gene Therapy Vectors for Delivery to Photoreceptors and Retinal Pigment Epitheld that our particles are flexible enough to sustain changes in the formulation to accommodate additional targeting sequences without losing their efficiency in transfecting neuronal cells in the retina. Together, these results give us the opportunity to even further improve our particles.
