標(biāo)題: Titlebook: Resistance to Anti-Cancer Therapeutics Targeting Receptor Tyrosine Kinases and Downstream Pathways; Yosef Yarden,Moshe Elkabets Book 2018 [打印本頁(yè)] 作者: Ejaculation 時(shí)間: 2025-3-21 17:49
書目名稱Resistance to Anti-Cancer Therapeutics Targeting Receptor Tyrosine Kinases and Downstream Pathways影響因子(影響力)
書目名稱Resistance to Anti-Cancer Therapeutics Targeting Receptor Tyrosine Kinases and Downstream Pathways影響因子(影響力)學(xué)科排名
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書目名稱Resistance to Anti-Cancer Therapeutics Targeting Receptor Tyrosine Kinases and Downstream Pathways網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Resistance to Anti-Cancer Therapeutics Targeting Receptor Tyrosine Kinases and Downstream Pathways被引頻次
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書目名稱Resistance to Anti-Cancer Therapeutics Targeting Receptor Tyrosine Kinases and Downstream Pathways讀者反饋
書目名稱Resistance to Anti-Cancer Therapeutics Targeting Receptor Tyrosine Kinases and Downstream Pathways讀者反饋學(xué)科排名
作者: 不愿 時(shí)間: 2025-3-21 22:05 作者: 草率女 時(shí)間: 2025-3-22 04:21
https://doi.org/10.1007/978-3-319-67932-7Anti-cancer; Kinases; Resistance; Tyrosine; therapeutics作者: Perineum 時(shí)間: 2025-3-22 04:46 作者: 拾落穗 時(shí)間: 2025-3-22 11:38 作者: 放肆的你 時(shí)間: 2025-3-22 14:54 作者: 光明正大 時(shí)間: 2025-3-22 19:54 作者: 植物學(xué) 時(shí)間: 2025-3-23 00:08
RAF, MEK and ERK Inhibitors as Anti-Cancer Drugs: Intrinsic and Acquired Resistance as a Major Therd cancers. Several resistance mechanisms have been proposed up to date, which result from either preexisting mechanisms in some or all cells within the tumors or due to drug-induced mechanisms. These include (a) expression of drug-resistant RAF isoforms (b) molecular or genetic alterations of downst作者: reperfusion 時(shí)間: 2025-3-23 01:53 作者: 滲入 時(shí)間: 2025-3-23 07:04 作者: 禁止 時(shí)間: 2025-3-23 10:48
Resistance Mechanisms to Cyclin-Dependent Kinase Inhibitors,but have yet to be FDA-approved in human cancers. Preclinical studies are beginning to shed light on inherent and acquired mechanisms of resistance to CDKi. Several cancer-relevant signaling pathways, such as the MAPK and PI3K pathways, drive cell cycle progression and contribute to CDK activity, su作者: 比賽用背帶 時(shí)間: 2025-3-23 15:53
Resistance to Inhibitors of Angiogenesis,he upregulation of bypass angiogenic pathways, pro-angiogenic activity of infiltrating stromal cells and alternative vascularization processes. In addition, off-target effects of anti-angiogenic drugs have implications for tumor aggressiveness. In this chapter, we discuss the molecular and cellular 作者: SEVER 時(shí)間: 2025-3-23 19:52 作者: 聾子 時(shí)間: 2025-3-24 00:26 作者: 美色花錢 時(shí)間: 2025-3-24 02:43
Maicol Mancini,Yosef Yardents in a decrease in the number of iterations required to solve the resulting linear systems which for the cases studied ranges from 50% up to several orders of magnitude..The propagating crack is represented using a 3D version of the level set method (Ventura et al., Int. J. Numer. Methods Eng. 58(1作者: 泥瓦匠 時(shí)間: 2025-3-24 09:01 作者: 共棲 時(shí)間: 2025-3-24 11:30
Konstantinos V. Floros,Anthony C. Faber,Hisashi Haradafalls hat aber erst . (um 225 v. Chr.) die Erzeugung der drei Kurven durch Schnitte schiefer Kegel von kreisf?rmiger Basis zum Ausgangspunkt geometrischer Untersuchungen genommen.). Auch erkannte . die Eigenschaften der Kegelschnitte, die durch ihre ?Scheitelgleichungen“ ausgedrückt werden und Anlas作者: Cholesterol 時(shí)間: 2025-3-24 17:43
Wolf Ruprecht Wiedemeyerogischen Zusammenhang ich jetzt nur mit Mühe wiederfinden kann, gefiel mir sehr, und ich nahm ein Blatt Papier, um sie schriftlich darzulegen, aber dabei kam mir eine solche Menge Gedanken in den Kopf, da? ich aufstehen mu?te und im Zimmer auf und ab gehen.978-3-322-93980-7作者: debble 時(shí)間: 2025-3-24 21:40
Nili Dahan,Ksenia Magidey,Yuval Shakedogischen Zusammenhang ich jetzt nur mit Mühe wiederfinden kann, gefiel mir sehr, und ich nahm ein Blatt Papier, um sie schriftlich darzulegen, aber dabei kam mir eine solche Menge Gedanken in den Kopf, da? ich aufstehen mu?te und im Zimmer auf und ab gehen.978-3-322-93980-7作者: 傻 時(shí)間: 2025-3-25 00:58 作者: 獨(dú)裁政府 時(shí)間: 2025-3-25 06:08
Resistance to Anti-Cancer Therapeutics Targeting Receptor Tyrosine Kinases and Downstream Pathways作者: 大洪水 時(shí)間: 2025-3-25 10:04
Resistance of Colorectal Tumors to Anti-EGFR Antibodies,on genetic lesions and share analogous signaling traits. Here we discuss how resistance to the EGFR blockade is attained in colorectal cancer and elaborate on alternative therapeutic strategies that are now under development to improve response and contrast relapse.作者: Narcissist 時(shí)間: 2025-3-25 15:10
Book 2018, including tyrosine kinase inhibitors and monoclonal antibodies, blockers of growth factor receptors and their downstream pathways, which play essential functions in cancer progression. Each chapter will cover a specific group of targets and the cognate drugs, along with molecular modes of innate a作者: neologism 時(shí)間: 2025-3-25 16:42
2196-5501 ase inhibitors and monoclonal antibodies, that specifically .This volume comprehensively covers the multiplicity and diversity of mechanisms underlying patient resistance to currently approved anti-cancer drugs, including tyrosine kinase inhibitors and monoclonal antibodies, blockers of growth facto作者: 竊喜 時(shí)間: 2025-3-25 22:26
Resistance of Colorectal Tumors to Anti-EGFR Antibodies,s cetuximab or panitumumab (‘primary’ or ‘de novo’ resistance). Further, almost all patients who initially respond become resistant over the course of treatment (‘secondary’ or ‘a(chǎn)cquired’ resistance). Studies in cell lines, patient-derived tumorgrafts, and archival surgical specimens have identified作者: 暫時(shí)過(guò)來(lái) 時(shí)間: 2025-3-26 02:01
Resistance of Lung Cancer to Kinase Inhibitors Specific to EGFR or ALK,h factor receptor (EGFR) and the anaplastic lymphoma kinase (ALK) opened the way for development of relatively effective tyrosine kinase inhibitory (TKI) drugs, such as erlotinib and crizotinib, respectively. Unfortunately, resistance to these and other first-generation TKIs evolves in patients with作者: BRINK 時(shí)間: 2025-3-26 04:37
Mechanisms of Action and Resistance of Trastuzumab in Breast Cancer, 2017. Breast cancer-related deaths have declined over the last two decades as a result of early detection and improved treatment, particularly targeted therapies, such as trastuzumab that targets human epidermal growth factor receptor 2 (HER2), which is frequently overexpressed in breast cancer. Ho作者: 多樣 時(shí)間: 2025-3-26 11:56 作者: fiction 時(shí)間: 2025-3-26 12:52
RAF, MEK and ERK Inhibitors as Anti-Cancer Drugs: Intrinsic and Acquired Resistance as a Major Thereractivation as well as oncogenic activating mutations in the different components of the cascade (mainly RAS, RAF and MEK) have inspired the development of several inhibitors targeting the different tiers of the cascade. As a result, clinically approved RAF and MEK inhibitors are used for targeted 作者: Hypopnea 時(shí)間: 2025-3-26 17:20
Mechanisms of Resistance to PI3K and AKT Inhibitors,te the binding and activation of PI3K, or as a consequence of activating alterations of the nodes of the signaling cascade, deregulated PI3K signaling can promote tumor growth and survival. This provided the rationale to develop inhibitors targeting virtually all the components of this pathway. Desp作者: PTCA635 時(shí)間: 2025-3-26 21:30 作者: Saline 時(shí)間: 2025-3-27 01:48
Resistance Mechanisms to Cyclin-Dependent Kinase Inhibitors, cycle deregulation is a hallmark of cancer, and CDKs have long been considered attractive targets for anti-cancer agents. After initial failures of pan-CDKi in clinical trials, two highly specific CDK4/6 inhibitors, palbociclib and ribociclib, are now FDA-approved in hormone receptor-positive breas作者: arboretum 時(shí)間: 2025-3-27 07:27 作者: 類人猿 時(shí)間: 2025-3-27 11:04 作者: 上流社會(huì) 時(shí)間: 2025-3-27 16:57
Mechanisms of Action and Resistance of Trastuzumab in Breast Cancer,wever, resistance to trastuzumab, either . or acquired resistance, presents a major clinical challenge. Here, we summarize the mechanisms of action and resistance of trastuzumab in breast cancer and discuss potential strategies to overcome resistance.作者: Temporal-Lobe 時(shí)間: 2025-3-27 20:57 作者: 美色花錢 時(shí)間: 2025-3-28 01:22
a geometric structure or a long-range interaction. The farther spin interactions than the nearest sites stem from a coupling with other degrees of freedom in many realistic materials. Among them, the spin-lattice interaction has a large contribution for the effective spin interaction, and the spin-P作者: 嫻熟 時(shí)間: 2025-3-28 03:36 作者: 不持續(xù)就爆 時(shí)間: 2025-3-28 09:34 作者: Substance 時(shí)間: 2025-3-28 12:54 作者: 轉(zhuǎn)折點(diǎn) 時(shí)間: 2025-3-28 17:08
Konstantinos V. Floros,Anthony C. Faber,Hisashi Harada Seitenlinie eines . gelegt. Je nachdem der Winkel zwischen Axe und Seitenlinie dieses Kegels kleiner, gleich oder gr?sser als ein halber Rechter war, unterschied man Schnitte des spitzwinkligen, rechtwinkligen, stumpfwinkligen Kegels oder, wie wir heute sagen, Ellipsen, Parabeln, Hyperbeln.). Die E作者: Toxoid-Vaccines 時(shí)間: 2025-3-28 21:16 作者: 腐敗 時(shí)間: 2025-3-29 00:47 作者: 厭倦嗎你 時(shí)間: 2025-3-29 05:48 作者: intoxicate 時(shí)間: 2025-3-29 08:10
1421-6329 ore it reached Italy. Abbacus algebra – eventually the main inspiration for the algebraic breakthrough of the 16.th. and 17.th. centuries – was inspired from a Romance-speaking region outside 978-3-7643-8391-6Series ISSN 1421-6329 Series E-ISSN 2296-6080 作者: 防水 時(shí)間: 2025-3-29 13:31
Barrieren für grenzüberschreitende Versicherungsvertr?ge gefallen. Ausl?ndische Versicherer k?nnen ihre Produkte heute ohne weiteres im Inland vertrei- ben, inl?ndische Versicherer auf ausl?ndische M?rkte expan- dieren. Damit tritt das Internationale Versicherungsvertragsrecht aus seinem bisherigen作者: Diverticulitis 時(shí)間: 2025-3-29 17:21 作者: sphincter 時(shí)間: 2025-3-29 22:02
NGH as an Unconventional Energy Resource, related to obtaining secure local gas resources might be more important to NGH development than the delivered gas price of imported resources. Near term development plans for NGH including drilling and gas production tests are being pursued, particularly in Japan, India, Korea, and possibly China.
