標題: Titlebook: Research in Computational Molecular Biology; 21st Annual Interna S. Cenk Sahinalp Conference proceedings 2017 Springer International Publi [打印本頁] 作者: OBESE 時間: 2025-3-21 19:56
書目名稱Research in Computational Molecular Biology影響因子(影響力)
書目名稱Research in Computational Molecular Biology影響因子(影響力)學科排名
書目名稱Research in Computational Molecular Biology網(wǎng)絡公開度
書目名稱Research in Computational Molecular Biology網(wǎng)絡公開度學科排名
書目名稱Research in Computational Molecular Biology被引頻次
書目名稱Research in Computational Molecular Biology被引頻次學科排名
書目名稱Research in Computational Molecular Biology年度引用
書目名稱Research in Computational Molecular Biology年度引用學科排名
書目名稱Research in Computational Molecular Biology讀者反饋
書目名稱Research in Computational Molecular Biology讀者反饋學科排名
作者: Bureaucracy 時間: 2025-3-21 22:59
Dan DeBlasio,John Kececiogluulated by certain chemical reactions that modulate parts of the genome at specific intervals involving the remodeling of chromatin. Understanding how chromatin remodeling can selectively activate or inactivate genes and subsequently influence pathogenesis and the outcome of many diseases becomes cri作者: sclera 時間: 2025-3-22 03:22
Wontack Han,Mingjie Wang,Yuzhen Yees not only to enter but also infect a wide range of cells. Making use of this property, scientists have manipulated viruses to express therapeutic genes. These viruses serve as vehicles for gene delivery and are referred to as viral vectors. The ones that are currently used in gene therapy include 作者: 可能性 時間: 2025-3-22 06:41
David Haussler,Maciej Smuga-Otto,Benedict Paten,Adam M. Novak,Sergei Nikitin,Maria Zueva,Dmitrii Miain patients with hematologic malignancies, leading to the FDA approval of five CAR-T cells for relapsed or refractory B cell malignancies. The components of these CARs (the extracellular antigen-binding domain, hinge and transmembrane region, co-stimulatory domains, and activation domain) were metho作者: 兵團 時間: 2025-3-22 12:49
Guillaume Holley,Roland Wittler,Jens Stoye,Faraz Hachroaches target PD1/PDL1 pathway or use specific autologous T-cells genetically modified to express a chimeric antigen receptor (CAR). Although promising, in most patients with solid malignancies these approaches either do not work or the disease becomes resistant to treatment. Unlike CAR-T cell ther作者: wall-stress 時間: 2025-3-22 13:21
Chirag Jain,Alexander Dilthey,Sergey Koren,Srinivas Aluru,Adam M. Phillippyng the treatment landscape of serious medical conditions such as autoimmune diseases, neurodegenerative disorders, and cancer. These products, including autologous or allogeneic lymphocytes, chimeric antigen receptor (CAR)-T cells, antigen-presenting cells, or cancer cells manipulated or processed e作者: 浸軟 時間: 2025-3-22 18:14 作者: 光亮 時間: 2025-3-23 00:19
Uri Keich,William Stafford NobleA) approval was in 2017 for CD19-directed CAR-T cell therapy using tisagenlecleucel (tisa-cel) for the treatment of pediatric patients (up to age 25) with relapsed or refractory (R/R) B-acute lymphoblastic leukemia (B-ALL). That same year, CD19 CAR-T cell therapy with axicabtagene ciloleucel (axi-ce作者: Directed 時間: 2025-3-23 04:30 作者: 改進 時間: 2025-3-23 09:12
Robert Osazuwa Ness,Karen Sachs,Parag Mallick,Olga Vitekenbaum oder ein Stammbaum, der unsere Beobachtungen mit den einfachsten Annahmen erkl?ren kann, ist natürlich an sich schon attraktiv. Zumindest aber sollte er ein guter Ausgangspunkt für weitere Betrachtungen sein. . wird allerdings gerade wegen seiner konzeptionellen Einfachheit von einigen moleku作者: 啜泣 時間: 2025-3-23 09:42 作者: CRUMB 時間: 2025-3-23 15:24
Elior Rahmani,Regev Schweiger,Liat Shenhav,Eleazar Eskin,Eran Halperindiffusion distances, and growing tumor masses. The proteomic and metabolomic landscape of the hypoxic cells is reprogrammed through hypoxia-induced transcription factor 1 which is activated in hypoxic conditions and is inactive when oxygen is abundant. This transcription factor has also been shown t作者: 脫離 時間: 2025-3-23 21:02 作者: Cardioversion 時間: 2025-3-23 22:45
Regev Schweiger,Eyal Fisher,Elior Rahmani,Liat Shenhav,Saharon Rosset,Eran Halperin. Methods for engineering and analysis of nucleic acids, from polymerase chain reaction to Cre-Lox recombination, are contributing greatly to biomarkers’ discovery, mapping of cellular signaling cascades, and smart design of therapeutics in precision medicine. Investigating the different subtypes of作者: recession 時間: 2025-3-24 03:42
Brad Solomon,Carl Kingsfordg unmatched demand of available organ donors and, as a consequence, the continuous growth of patients’ waiting lists, the development of new tissue engineering technologies is a relevant need. In this chapter, we will focus on the liver as a model organ to discuss contemporary tissue engineering str作者: 芳香一點 時間: 2025-3-24 09:09 作者: BRIBE 時間: 2025-3-24 12:58 作者: 歌曲 時間: 2025-3-24 18:21
Yue Wu,Farhad Hormozdiari,Jong Wha J. Joo,Eleazar Eskinbehandelt. Dabei zerf?llt dasThema im Wesentlichen in zwei Gebiete, über die Ausführliches zu lesen ist. Zum einen findet man Darstellungen zur speziellen Evolution der menschlichen Art, illustriert anhand der fossilen Hinterlassenschaften; und zum anderen mehr oder weniger originelle Ableitungen po作者: entail 時間: 2025-3-24 20:45
Determining the Consistency of Resolved Triplets and Fan Triplets,how the computational complexity of the problem changes under various restrictions. Our main result is an efficient algorithm for dense inputs satisfying . whose running time is linear in the size of the input and therefore optimal.作者: 冥界三河 時間: 2025-3-25 02:26
0302-9743 refully reviewed and selected from 184 submissions. 16 short abstracts are included in the back matter of the volume. They report on original research in all areas of computational molecular biology and bioinformatics978-3-319-56969-7978-3-319-56970-3Series ISSN 0302-9743 Series E-ISSN 1611-3349 作者: 開始沒有 時間: 2025-3-25 04:19 作者: Narcissist 時間: 2025-3-25 09:31
Boosting Alignment Accuracy by Adaptive Local Realignment,ng-function parameters across a protein’s entire length. We present a new approach, called ., that in contrast automatically adapts to the diversity of mutation rates along protein sequences. This builds upon a recent technique known as parameter advising that finds global parameter settings for ali作者: 單挑 時間: 2025-3-25 12:20
A Concurrent Subtractive Assembly Approach for Identification of Disease Associated Sub-metagenomesost status). The typical workflow is to assemble and annotate metagenomic datasets individually or as a whole, followed by statistical tests to identify differentially abundant species/genes. We previously developed subtractive assembly (SA), a . assembly approach for comparative metagenomics that f作者: NEG 時間: 2025-3-25 17:06 作者: AGATE 時間: 2025-3-25 21:11 作者: mastoid-bone 時間: 2025-3-26 00:20 作者: 演講 時間: 2025-3-26 07:59
Determining the Consistency of Resolved Triplets and Fan Triplets, that contains all elements in?. and no elements in?. as embedded subtrees, if such a tree exists. This paper presents a detailed characterization of how the computational complexity of the problem changes under various restrictions. Our main result is an efficient algorithm for dense inputs satisfy作者: faultfinder 時間: 2025-3-26 09:51
Progressive Calibration and Averaging for Tandem Mass Spectrometry Statistical Confidence EstimatioHere we offer two new methods that can use an arbitrarily small number of additional randomly drawn decoy databases to improve TDC. Specifically, “Partial Calibration” utilizes a new meta-scoring scheme that allows us to gradually benefit from the increase in the number of identifications calibratio作者: expansive 時間: 2025-3-26 16:06
Resolving Multicopy Duplications , Using Polyploid Phasing,segmental duplications in the genome still remain a challenging frontier in assembly. Segmental duplications are at the same time both gene rich and prone to large structural rearrangements, making the resolution of their sequences important in medical and evolutionary studies. Duplicated sequences 作者: adjacent 時間: 2025-3-26 20:05
A Bayesian Active Learning Experimental Design for Inferring Signaling Networks,ction networks. They provide insight into the rewiring of signaling within the context of a disease or a phenotype. To learn the causal patterns of influence between proteins in the network, the methods require experiments that include targeted interventions that fix the activity of specific protein作者: 血友病 時間: 2025-3-26 22:03 作者: 放縱 時間: 2025-3-27 01:21 作者: isotope 時間: 2025-3-27 06:32 作者: Anonymous 時間: 2025-3-27 11:38
A Bayesian Framework for Estimating Cell Type Composition from DNA Methylation Without the Need foratus is suggested to hold great potential for better understanding the role of epigenetics. Different cell types are known to have different methylation profiles. Therefore, in the common scenario where methylation levels are collected from heterogeneous sources such as blood, convoluted signals are作者: 聲音刺耳 時間: 2025-3-27 16:46 作者: calamity 時間: 2025-3-27 20:52
Using Stochastic Approximation Techniques to Efficiently Construct Confidence Intervals for Heritabted quantities has received much recent attention, due of its ability to account for variants with small effect sizes. Typically, heritability estimation under LMMs uses the restricted maximum likelihood (REML) approach. The common way to report the uncertainty in REML estimation uses standard error作者: 過渡時期 時間: 2025-3-27 23:40 作者: 大吃大喝 時間: 2025-3-28 06:00
AllSome Sequence Bloom Trees,hing methods. One particular example is a database of 2,652 human RNA-seq experiments uploaded to the Sequence Read Archive. Recently, Solomon and Kingsford proposed the Sequence Bloom Tree data structure and demonstrated how it can be used to accurately identify SRA samples that have a transcript o作者: Obverse 時間: 2025-3-28 09:44 作者: 方舟 時間: 2025-3-28 13:30 作者: Texture 時間: 2025-3-28 16:28
Conference proceedings 2017ina, in May 2017.. The 22 regular papers presented in this volume were carefully reviewed and selected from 184 submissions. 16 short abstracts are included in the back matter of the volume. They report on original research in all areas of computational molecular biology and bioinformatics作者: 裝飾 時間: 2025-3-28 21:16
Boosting Alignment Accuracy by Adaptive Local Realignment,ew method of ., when combined with prior methods for global advising, boosts alignment accuracy as much as?26% over the best default setting on hard-to-align protein benchmarks, and by?6.4% over global advising alone. Adaptive local realignment, implemented within the . aligner using the . accuracy estimator, is available at ..作者: 低三下四之人 時間: 2025-3-29 02:43
A Bayesian Active Learning Experimental Design for Inferring Signaling Networks, and selects interventions that maximize their expected contribution to structure learning. Evaluations on simulated and real data show that the strategy reduces the detection error of validated edges as compared to an unguided choice of interventions, and avoids redundant interventions, thereby increasing the effectiveness of the experiment.作者: 間接 時間: 2025-3-29 04:49
AllSome Sequence Bloom Trees,mption during queries. Notably, it can query a batch of 198,074 queries in under 8?h (compared to around two days previously) and a whole set of .-mers from a sequencing experiment (about 27 mil .-mers) in under 11?min.作者: 玩笑 時間: 2025-3-29 07:17 作者: 含水層 時間: 2025-3-29 12:08
Christopher Pockrandt,Marcel Ehrhardt,Knut Reinert作者: SOW 時間: 2025-3-29 19:22
enhance and regulate a gene therapy or vice versa. Such combined approaches can hence increase the specificity and efficiency of the final therapy which may be much better than the individual ones. There are many hurdles to such dual-modality processes and hence must be employed after careful evalu作者: negligence 時間: 2025-3-29 21:12 作者: 消音器 時間: 2025-3-30 03:20 作者: BARB 時間: 2025-3-30 06:53 作者: 使出神 時間: 2025-3-30 10:47 作者: MOAT 時間: 2025-3-30 14:48 作者: 老人病學 時間: 2025-3-30 20:25
Jesper Jansson,Andrzej Lingas,Ramesh Rajaby,Wing-Kin Sunger strategies involve combining existing CAR-T therapies with other treatment modalities. In this chapter, we will focus on combination strategies that are currently being used and/or are under exploration. We will first discuss strategies used to increase CAR-T effectiveness through combination wit作者: SHRIK 時間: 2025-3-30 23:28 作者: Palpitation 時間: 2025-3-31 02:47 作者: 共同給與 時間: 2025-3-31 06:30 作者: crucial 時間: 2025-3-31 13:14
Adegoke A. Ojewole,Jonathan D. Jou,Vance G. Fowler,Bruce R. Donaldtens?tze zu Supermatrices und vor allem wie gro?e Mengen unabh?ngiger, oft inkongruenter, B?ume zu . verknüpft werden k?nnen, wollen wir zumindest kurz umrei?en. Schlie?lich: B?ume an sich sind nicht immer der Weisheit letzter Schluss. In der Evolution ist viel mehr passiert, als das lediglich aberm作者: 返老還童 時間: 2025-3-31 13:31 作者: Spinal-Fusion 時間: 2025-3-31 19:23 作者: 云狀 時間: 2025-4-1 01:40 作者: Anticoagulant 時間: 2025-4-1 04:29
