標(biāo)題: Titlebook: Research in Computational Molecular Biology; 19th Annual Internat Teresa M. Przytycka Conference proceedings 2015 Springer International Pu [打印本頁] 作者: 力學(xué) 時間: 2025-3-21 17:52
書目名稱Research in Computational Molecular Biology影響因子(影響力)
書目名稱Research in Computational Molecular Biology影響因子(影響力)學(xué)科排名
書目名稱Research in Computational Molecular Biology網(wǎng)絡(luò)公開度
書目名稱Research in Computational Molecular Biology網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Research in Computational Molecular Biology被引頻次
書目名稱Research in Computational Molecular Biology被引頻次學(xué)科排名
書目名稱Research in Computational Molecular Biology年度引用
書目名稱Research in Computational Molecular Biology年度引用學(xué)科排名
書目名稱Research in Computational Molecular Biology讀者反饋
書目名稱Research in Computational Molecular Biology讀者反饋學(xué)科排名
作者: 丑惡 時間: 2025-3-21 20:43
Srinivas Aluru,Alberto Apostolico,Sharma V. Thankachan transfer takes a considerable advantage of delivering the transgene into neuronal cell bodies situated in regions distant from the injection site of the vectors. The rational use of these two vector groups characterized by different entry mechanisms will further extend the strategy for gene therapy作者: 有偏見 時間: 2025-3-22 03:18
Naama Amir,Dan Cohen,Haim J. Wolfsontation, split AAV vectors, and fragment AAV (fAAV) genome reassembly (Hirsch et al., Mol Ther 18(1):6–8, 2010). Split rAAV vector applications were developed based upon the finding that rAAV genomes naturally concatemerize in the cell post-transduction and are substrates for enhanced homologous reco作者: Feckless 時間: 2025-3-22 06:52
Ilan Ben-Bassat,Benny Chorin host-cells in the process of replicating and synthesizing their own genomic DNA (an exception is in the human immunodeficiency virus [HIV] family of retroviruses), which allows the targeting of the virus to rapidly dividing cells and not postmitotic cells .. The viral genes in the vector genome w作者: Esophagus 時間: 2025-3-22 09:41
Emily Berger,Deniz Yorukoglu,Bonnie Berger-oncology since the mid-1970s .. Druckrey ., Benda, Schmidek, Swenberg, and Koestner . and their associates reported that central nervous system tumors could be induced selectively and reproducibly in adult rats that had been given repeated, weekly, intravenous (iv) injections of N-methylnitrosourea作者: 自作多情 時間: 2025-3-22 12:58
Alex Bishara,Yuling Liu,Dorna Kashef-Haghighi,Ziming Weng,Daniel E. Newburger,Robert West,Arend Sido two clinical trials are currently underway using adenovirus vectors to treat gliomas .. Vector applications can be categorized on the basis of the desired duration of transgene expression and the effect of the immune response on the target cell. For example, correction of such disorders as Parkinso作者: exclusice 時間: 2025-3-22 17:34
Surojit Biswas,Meredith McDonald,Derek S. Lundberg,Jeffery L. Dangl,Vladimir Jojicments in the context of the appropriateness of the experimental model may produce misleading conclusions that could delay the rational development of efficacious immunotherapeutic strategies. In the second part of this chapter, the recent literature dealing with the use of cytokine gene transfer to 作者: 瘙癢 時間: 2025-3-22 23:22 作者: Affectation 時間: 2025-3-23 01:51 作者: MIRE 時間: 2025-3-23 06:46
Hyunghoon Cho,Bonnie Berger,Jian Penglevels respectively; (2) gene therapies that alter the balance between collagen synthesis and degradation focusing on directly reducing collagen production through miRNA-29b or inducing collagen degradation through TIMP siRNAs, or decreasing collagen accumulation through PAI-1-targeting siRNAs or HS作者: Lacunar-Stroke 時間: 2025-3-23 13:21 作者: antenna 時間: 2025-3-23 14:47
Rasmus Fonseca,Henry van den Bedem,Julie Bernauerbitors such as IL-1 receptor antagonist (IL-lRa), soluble interferon gamma (IFNβ) receptor (IFNβR)/IgG-Fc fusion protein, or TNFα receptor (TNFR). Furthermore, in vivo transfer of nucleic acid segments (or plasmid-based delivery of these molecules), such as cytosine-phosphate-guanine (CpG)-containin作者: Affirm 時間: 2025-3-23 19:41 作者: 極大痛苦 時間: 2025-3-23 22:47 作者: 戲法 時間: 2025-3-24 05:38
Mark A. Hallen,Bruce R. Donaldrventions, use of novel gene therapeutic technologies such as CRISPR/Cas, sleeping beauty vectors, and development of effective cancer immunogene therapies. In this chapter, a brief overview of current key developments in cancer gene therapy is provided to gain insights into the recent directions in作者: habitat 時間: 2025-3-24 10:04
Jong Wha J. Joo,Eun Yong Kang,Elin Org,Nick Furlotte,Brian Parks,Aldons J. Lusis,Eleazar Eskinrventions, use of novel gene therapeutic technologies such as CRISPR/Cas, sleeping beauty vectors, and development of effective cancer immunogene therapies. In this chapter, a brief overview of current key developments in cancer gene therapy is provided to gain insights into the recent directions in作者: chisel 時間: 2025-3-24 12:29
Jonathan D. Jou,Swati Jain,Ivelin Georgiev,Bruce R. Donaldility requirement for a globally available therapy..One alternative method for engineering of T cells is the nonviral gene transfer by . (SB) transposition. Electroporation with two nucleic acids is sufficient to achieve stable CAR transfer into T cells. One of these vectors has to encode the gene o作者: 形容詞 時間: 2025-3-24 17:54
Seunghak Lee,Aurélie Lozano,Prabhanjan Kambadur,Eric P. Xingbleshooting and avoiding known pitfalls...Cutting edge and authoritative, "Gene Therapy of Cancer: Methods and Protocols, Second Edition" is an ideal guide for all those who wish to explore the fast-paced and critical study of nonviral, viral, experimental and clinical cancer gene therapy..作者: resuscitation 時間: 2025-3-24 21:41 作者: 使虛弱 時間: 2025-3-25 00:26 作者: 軍火 時間: 2025-3-25 05:58
Efficient Alignment Free Sequence Comparison with Bounded Mismatches,mance. In this paper, we close the gap by presenting the first provably efficient algorithm for the .. (.) problem that takes . space and . time in the worst case for any constant .. Our method extends the generalized suffix tree model to incorporate a carefully selected bounded set of perturbed suf作者: Venules 時間: 2025-3-25 08:30
Learning Microbial Interaction Networks from Metagenomic Count Data,el, but not SparCC or glasso, correctly resolves a direct interaction structure among three community members that associate with . roots. We conclude that our method provides a structured, accurate, and distributionally reasonable way of modeling correlated count based random variables and capturin作者: 縱欲 時間: 2025-3-25 15:41 作者: CROAK 時間: 2025-3-25 19:51
KGSrna: Efficient 3D Kinematics-Based Sampling for Nucleic Acids, analysis-based exploration, our procedure diffuses faster through the experimental ensemble while also accessing conformational substates to greater precision. Our results suggest that conformational sampling with a highly reduced but fully atomistic representation of noncoding RNA expresses key fe作者: 稱贊 時間: 2025-3-25 20:09 作者: reaching 時間: 2025-3-26 02:19
Efficient and Accurate Multiple-Phenotypes Regression Method for High Dimensional Data Considering e positive identifications. We further apply our method to genetic studies of yeast and gut microbiome from mouse and show that GAMMA identifies several variants that are likely to have a true biological mechanism.作者: 你不公正 時間: 2025-3-26 06:04 作者: 我不怕犧牲 時間: 2025-3-26 08:27 作者: CLOUT 時間: 2025-3-26 14:00 作者: 調(diào)整 時間: 2025-3-26 20:15 作者: oblique 時間: 2025-3-27 00:27 作者: 云狀 時間: 2025-3-27 04:39
Exploration of Designability of Proteins Using Graph Features of Contact Maps: Beyond Lattice Modelloop type structures or structures that are loosely packed. Interestingly enough, it can also be seen that these highly designable structures obtained are also common structural motifs found in nature.作者: 皺痕 時間: 2025-3-27 06:37
, (Constrained Optimization of Multistate Energies by Tree Search): A Provable and Efficient Algorithan the previous state of the art for provable multistate design (exhaustive search over sequences). . can handle a very wide range of protein flexibility and can enumerate a gap-free list of the best constraint-satisfying sequences in order of objective function value.作者: 乞討 時間: 2025-3-27 09:58
BWM*: A Novel, Provable, Ensemble-Based Dynamic Programming Algorithm for Sparse Approximations of A. in 49 of 67 protein design problems, computing the full ensemble or a close approximation up?to two orders of magnitude faster. Performance of BWM. can be predicted cheaply beforehand, allowing selection of the most efficient algorithm for each design problem.作者: Toxoid-Vaccines 時間: 2025-3-27 15:11
Efficient Alignment Free Sequence Comparison with Bounded Mismatches, and phylogentic reconstruction. Among the methods based on substring composition, the . (.) measure proposed by Burstein . (RECOMB 2005) admits a straightforward linear time sequence comparison algorithm, while yielding impressive results in multiple applications. An important direction of research作者: DEI 時間: 2025-3-27 20:54
CRISPR Detection from Short Reads Using Partial Overlap Graphs,tive immune system against phages. Most of the automated tools that detect CRISPR loci rely on assembled genomes. However, many assemblers do not successfully handle repetitive regions. The first tool to work directly on raw sequence data is Crass, which requires that reads are long enough to contai作者: 青少年 時間: 2025-3-27 22:37
HapTree-X: An Integrative Bayesian Framework for Haplotype Reconstruction from Transcriptome and Geotide polymorphism (SNP) site. However, in the case of two heterozygous SNP sites, genotype calling tools cannot determine whether “mutant” alleles from different SNP loci are on the same chromosome or on different homologous chromosomes (i.e. compound heterozygote).作者: municipality 時間: 2025-3-28 04:41 作者: PHON 時間: 2025-3-28 07:33 作者: EXALT 時間: 2025-3-28 10:52 作者: ironic 時間: 2025-3-28 14:47 作者: 開始從未 時間: 2025-3-28 19:53
KGSrna: Efficient 3D Kinematics-Based Sampling for Nucleic Acids,ational modification and protein synthesis. Their activity is modulated by highly dynamic exchanges between three-dimensional conformational substates, which are difficult to characterize experimentally and computationally. Here, we present an innovative, entirely kinematic computational procedure t作者: 協(xié)議 時間: 2025-3-29 01:04 作者: 考得 時間: 2025-3-29 07:04 作者: gorgeous 時間: 2025-3-29 11:00 作者: 拍下盜公款 時間: 2025-3-29 15:22 作者: accessory 時間: 2025-3-29 17:26
BWM*: A Novel, Provable, Ensemble-Based Dynamic Programming Algorithm for Sparse Approximations of mation (GMEC). This disproportionately favors the sequence of a single, static conformation and overlooks better sequences with multiple low-energy conformations. We propose a novel, provable, dynamic programming algorithm called .. (BWM.) to enumerate a gap-free ensemble of conformations in order o作者: 門閂 時間: 2025-3-29 21:19
An Efficient Nonlinear Regression Approach for Genome-Wide Detection of Marginal and Interacting Ge However, detecting pairwise interaction effects of genetic variants on traits still remains a challenge due to a large number of combinations of variants (. SNP pairs in the human genome), and relatively small sample sizes (typically .). Despite recent breakthroughs in detecting interaction effects作者: 心神不寧 時間: 2025-3-30 00:07 作者: BATE 時間: 2025-3-30 06:31
CoMEt: A Statistical Approach to Identify Combinations of Mutually Exclusive Alterations in Cancer,nguish these events from random passenger mutations that have no consequence for cancer. Identifying driver mutations is a significant challenge due to the mutational heterogeneity of tumors: different combinations of somatic mutations drive different tumors, even those of the same cancer type.作者: 憂傷 時間: 2025-3-30 11:16 作者: 格子架 時間: 2025-3-30 12:22
Research in Computational Molecular Biology978-3-319-16706-0Series ISSN 0302-9743 Series E-ISSN 1611-3349 作者: Entirety 時間: 2025-3-30 16:35
Lecture Notes in Computer Sciencehttp://image.papertrans.cn/r/image/827956.jpg作者: Ornithologist 時間: 2025-3-30 23:37
https://doi.org/10.1007/978-3-319-16706-0bioinformatics; biological networks; cancer; chromatin structure; computational biology; computational pr作者: gustation 時間: 2025-3-31 03:00
DockStar: A Novel ILP Based Integrative Method for Structural Modelling of Multimolecular Protein CAtomic resolution modelling of large multimolecular protein complexes is a key task in Structural Cell Biology. A single cell consists of hundreds of different functional complexes.作者: Cacophonous 時間: 2025-3-31 05:54 作者: 600 時間: 2025-3-31 10:36
Diffusion Component Analysis: Unraveling Functional Topology in Biological Networks,Complex biological systems have been successfully modeled by biochemical and genetic interaction networks, typically gathered from high-throughput (HTP) data. These networks can be used to infer functional relationships between genes or proteins.作者: BARK 時間: 2025-3-31 16:34
Teresa M. PrzytyckaIncludes supplementary material: 作者: Indict 時間: 2025-3-31 18:46 作者: Confidential 時間: 2025-3-31 22:59 作者: 浪費(fèi)物質(zhì) 時間: 2025-4-1 04:39 作者: 高腳酒杯 時間: 2025-4-1 06:23 作者: 描繪 時間: 2025-4-1 13:53 作者: 勾引 時間: 2025-4-1 17:40
