標題: Titlebook: Research in Computational Molecular Biology; 24th Annual Internat Russell Schwartz Conference proceedings 2020 Springer Nature Switzerland [打印本頁] 作者: 胃口 時間: 2025-3-21 18:11
書目名稱Research in Computational Molecular Biology影響因子(影響力)
書目名稱Research in Computational Molecular Biology影響因子(影響力)學(xué)科排名
書目名稱Research in Computational Molecular Biology網(wǎng)絡(luò)公開度
書目名稱Research in Computational Molecular Biology網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱Research in Computational Molecular Biology被引頻次
書目名稱Research in Computational Molecular Biology被引頻次學(xué)科排名
書目名稱Research in Computational Molecular Biology年度引用
書目名稱Research in Computational Molecular Biology年度引用學(xué)科排名
書目名稱Research in Computational Molecular Biology讀者反饋
書目名稱Research in Computational Molecular Biology讀者反饋學(xué)科排名
作者: FRONT 時間: 2025-3-21 21:39
ethods and Protocols. aids scientists in understanding all the different stages of a complex gene synthesis process, while refining their understanding of gene synthesis and determine what part of the process they can or should do in their laboratory and what parts should be contracted to a speciali作者: Hangar 時間: 2025-3-22 04:21
Kamran Ghasedi Dizaji,Wei Chen,Heng Huange-copy gene delivery to a defined chromosomal position is particularly valuable to characterize mutant regulatory sequences driving a reporter gene or to evaluate mutant alleles and variant isoforms of a particular recombinant gene, as has been done, for example, with the angiotensin AT. receptor (.作者: 輕信 時間: 2025-3-22 05:33
Bar?? Ekim,Bonnie Berger,Yaron Orensteine-copy gene delivery to a defined chromosomal position is particularly valuable to characterize mutant regulatory sequences driving a reporter gene or to evaluate mutant alleles and variant isoforms of a particular recombinant gene, as has been done, for example, with the angiotensin AT. receptor (.作者: 字形刻痕 時間: 2025-3-22 08:44 作者: neutrophils 時間: 2025-3-22 16:38 作者: 紋章 時間: 2025-3-22 20:19
Pesho Ivanov,Benjamin Bichsel,Harun Mustafa,André Kahles,Gunnar R?tsch,Martin Vechevntriguing question: if the founder cell has the capacity for self-renewal,hematopoiesis would be stochastic and many primitive HSCs would be functioning simultaneously. On the other hand, if the primitive HSC has no capacity to self-renew, hematopoiesis would be characterised by clonal succession. A作者: 有節(jié)制 時間: 2025-3-22 23:15
Brandon Legried,Erin K. Molloy,Tandy Warnow,Sébastien Rochome equally apparent that backbone or pendant oligonucleotide modifications can alter olionucleotide uptake characteristics, although not always in the way intended. In this chapter, we will review the current state of knowledge concerning internalization pathways for modified and unmodified oligonu作者: SHOCK 時間: 2025-3-23 02:32
Sneha Mitra,Jianling Zhong,David M. MacAlpine,Alexander J. Harteminkween the negatively charged DNA and the positively charged DNA-binding domain serves not only to bind the DNA, but also to condense it into a compact toroid structure (Wagner et al., 1991a). As the ligand is covalently linked to the polylysine DNA-binding domain, after binding of the DNA, at least a作者: uncertain 時間: 2025-3-23 07:18
Amatur Rahman,Paul Medvedevcts of RNA splicing, 3′ end formation/polyadenylation, RNA localization, translation and stability of the cytoplasmic mRNA and protein all influence the production of a protein. In keeping with the purpose of this review, specific examples of each type of control will be described. Obviously, the ex作者: GROWL 時間: 2025-3-23 13:13
Matthew A. Reyna,Uthsav Chitra,Rebecca Elyanow,Benjamin J. Raphaelbiological membranes are, at this time, mostly speculative and require more research to fully define the processes involved in polynucleotide transport. This chapter will discuss what is known about the uptake of naked foreign DNA by muscle cells after intramuscular injection or implantation as well作者: 完全 時間: 2025-3-23 17:36
Hongyu Zheng,Carl Kingsford,Guillaume Mar?aisoth . and . systems for gene delivery and the identification of novel classes of therapeutic genes. The recent results obtained by gene therapy of inherited blindness and of some neurodegenerative disorders, as well as the progress made in several other clinical trials, now encourage informed and fi作者: intimate 時間: 2025-3-23 19:23
cles on epigenic elements, viral vectors, non-viral vectors as gene delivery systems, animal models of human diseases, inducible regulatory systems, gene therapy of cancer, AIDS, monogenic disorders and ongoing clinical trials. Gene therapy is the logical progression to human health management becau作者: Dri727 時間: 2025-3-24 01:31
Jasmijn A. Baaijens,Leen Stougie,Alexander Sch?nhuthinant genes into living cells and to permanently transduce them with a new genetic phenotype. During the last 15 years substantial progress has been made to produce safe and effective viral vectors, and we have witnessed an exponential growth in preclinical research and clinical development of recom作者: 諂媚于人 時間: 2025-3-24 04:32 作者: 牢騷 時間: 2025-3-24 09:50
Anton Bankevich,Pavel Pevznerould be considered a form of gene therapy. The con- cept of transfer of genetic information as a practical clinical tool arose from the gene-cloning technology, developed during the 1970s. Without the ability to isolate and replicate defined genetic sequences, it would be impossible to produce purified materi978-3-0348-7013-9978-3-0348-7011-5作者: exophthalmos 時間: 2025-3-24 11:13
Nico Borgsmüller,Jose Bonet,Francesco Marass,Abel Gonzalez-Perez,Nuria Lopez-Bigas,Niko Beerenwinkelansfer into the stem cell of the hematopoietic system, thus allowing the appropriate expression of the normal gene into the affected cells of hematopoietic or lymphoid lineage [33–35]. However, initial difficulties in obtaining efficient transduction of stem cells have led several investigators to a作者: FLINT 時間: 2025-3-24 15:12
Kristen Emery,Syamand Hasam,William Stafford Noble,Uri Keichrection of human diseases. The latter aspects emphasized themes related to biotechnology, the first part was by nature more general. We also included a few cont978-3-642-64704-8978-3-642-61122-3Series ISSN 1010-8793 作者: Muscularis 時間: 2025-3-24 21:35
Leonard Bohnenk?mper,Marília D. V. Braga,Daniel Doerr,Jens Stoyeex gene synthesis process, while refining their understanding of gene synthesis and determine what part of the process they can or should do in their laboratory and what parts should be contracted to a speciali978-1-4939-6200-6978-1-61779-564-0Series ISSN 1064-3745 Series E-ISSN 1940-6029 作者: ARIA 時間: 2025-3-25 01:24 作者: 無法解釋 時間: 2025-3-25 04:18
Computing the Rearrangement Distance of Natural Genomesduplicates of any marker. Therefore it still needs a delicate preprocessing of the input data in which excessive copies of unbalanced markers have to be removed..In this paper we present an algorithm solving the genomic distance problem for . genomes, in which any marker may occur an arbitrary numbe作者: 細查 時間: 2025-3-25 10:43
Deep Large-Scale Multi-task Learning Network for Gene Expression Inferencenature of gene expression data, and the existing deep models are prone to overfitting due to the lack of using the interrelations of target genes in the learning framework. To address these challenges, we formulate the gene expression inference as a multi-task learning problem and propose a novel de作者: 外來 時間: 2025-3-25 15:25
A Randomized Parallel Algorithm for Efficiently Finding Near-Optimal Universal Hitting Setseverage advanced theoretical and architectural techniques to parallelize and decrease memory usage in calculating .-mer hitting numbers; and (ii) we build upon techniques from randomized Set Cover to select universal .-mers much faster. We implemented these innovations in PASHA, the first randomized作者: 周興旺 時間: 2025-3-25 19:02 作者: 卷發(fā) 時間: 2025-3-25 23:40
Supervised Adversarial Alignment of?Single-Cell RNA-seq Datast is the accuracy of cell type assignment and the second is the inability to distinguish the batch (domain). We tested the method by using the resulting representation to align several different datasets. As we show, by overcoming batch effects our method was able to correctly separate cell types, 作者: 填料 時間: 2025-3-26 00:10
RoboCOP: Multivariate State Space Model Integrating Epigenomic Accessibility Data to Elucidate Genomnucleotide sequence to compute genome-wide probabilistic scores of nucleosome and TF occupancy, for hundreds of different factors at once. . can be applied to any epigenomic dataset that provides quantitative insight into chromatin accessibility in any organism, but here we apply it to MNase-seq dat作者: 有法律效應(yīng) 時間: 2025-3-26 07:42
Representation of ,-mer Sets Using Spectrum-Preserving String Sets store a set of .-mers using an order-of-magnitude less disk space than other lossless compression tools. The second one is an exact static .-mer membership index, UST-FM, which we show improves index size by 10–44% compared to other state-of-the-art low memory indices. Our tool is publicly availabl作者: elucidate 時間: 2025-3-26 09:52 作者: cocoon 時間: 2025-3-26 15:23 作者: 抒情短詩 時間: 2025-3-26 16:54
Polynomial-Time Statistical Estimation of Species Trees Under Gene Duplication and Losshods, is . under this GDL model. We also provide a simulation study evaluating ASTRAL-multi for species tree estimation under GDL. All scripts and datasets used in this study are available on the Illinois Data Bank: ..作者: 憤慨點吧 時間: 2025-3-26 22:41 作者: 適宜 時間: 2025-3-27 01:53
Bagging MSA Learning: Enhancing Low-Quality PSSM with Deep Learning for Accurate Protein Structure Pk. Structure property prediction models are then built upon such enhanced PSSM features for more accurate predictions. Empirical evaluation of CB513, CASP11, and CASP12 datasets indicate that our unsupervised enhancing scheme indeed generates more informative PSSM features for structure property prediction.作者: 斜谷 時間: 2025-3-27 09:16 作者: 西瓜 時間: 2025-3-27 12:26
: Fast and Optimal Sequence-to-Graph Alignmenting subsequence in the query to be aligned, resulting in a provably optimal alignment algorithm called ...Experimental evaluation of . shows that it is 1–2 orders of magnitude faster than state-of-the-art optimal algorithms on the task of aligning Illumina reads to reference genome graphs. Implementations and evaluations are available at ..作者: Headstrong 時間: 2025-3-27 13:49
Computing the Rearrangement Distance of Natural Genomesclude the polynomial-time computability of the inversion distance by Hannenhalli and Pevzner in 1995 and the introduction of the double-cut and join (DCJ) distance by Yancopoulos, Attie and Friedberg in 2005. Both results, however, rely on the assumption that the genomes under comparison contain the作者: exhilaration 時間: 2025-3-27 18:25
Deep Large-Scale Multi-task Learning Network for Gene Expression Inferenceerimental conditions. Despite the recent advances in high-throughput technologies, profiling the whole-genome set is still challenging and expensive. Based on the fact that there is high correlation among the expression patterns of different genes, the above issue can be addressed by a cost-effectiv作者: 打折 時間: 2025-3-27 23:38
A Randomized Parallel Algorithm for Efficiently Finding Near-Optimal Universal Hitting Setsy introduced as an alternative to the central idea of minimizers in sequence analysis with the hopes that they could more efficiently address common tasks such as computing hash functions for read overlap, sparse suffix arrays, and Bloom filters. A UHS is a set of .-mers that hit every sequence of l作者: 沒有希望 時間: 2025-3-28 03:40
Multiple Competition-Based FDR Control and Its Application to Peptide Detections gained significant popularity in other fields after Barber and Candés laid its theoretical foundation in a more general setting that included the feature selection problem?[.]. In both cases, the competition is based on a head-to-head comparison between an observed score and a corresponding decoy/作者: Jingoism 時間: 2025-3-28 07:35
Supervised Adversarial Alignment of?Single-Cell RNA-seq Data of the profiled cells, such representations are used by many downstream analyses methods ranging from pseudo-time reconstruction to clustering to alignment of scRNA-seq data from different experiments, platforms, and labs. Both supervised and unsupervised methods have been proposed to reduce the di作者: Misnomer 時間: 2025-3-28 12:25
Bagging MSA Learning: Enhancing Low-Quality PSSM with Deep Learning for Accurate Protein Structure Pnction of a protein. PSSM (Position-Specific Scoring Matrix) features are widely used in the structure property prediction. However, some proteins may have low-quality PSSM features due to insufficient homologous sequences, leading to limited prediction accuracy. To address this limitation, we propo作者: JAMB 時間: 2025-3-28 17:46
: Fast and Optimal Sequence-to-Graph Alignmentt alignment graph. To find a shortest path, we instantiate the A. paradigm with a novel domain-specific heuristic function that accounts for the upcoming subsequence in the query to be aligned, resulting in a provably optimal alignment algorithm called ...Experimental evaluation of . shows that it i作者: 加劇 時間: 2025-3-28 20:05 作者: 協(xié)議 時間: 2025-3-29 01:45 作者: abracadabra 時間: 2025-3-29 03:47 作者: temperate 時間: 2025-3-29 09:04 作者: ABASH 時間: 2025-3-29 12:11
Stochastic Sampling of Structural Contexts Improves the Scalability and Accuracy of RNA 3D Module Idconnected by loops whose local conformations are critical determinants of global 3D architectures. Such local 3D structures consist of conserved sets of non-canonical base pairs, called RNA modules. Their prediction from sequence data is thus a milestone toward 3D structure modelling. Unfortunately,作者: gout109 時間: 2025-3-29 17:40
Lower Density Selection Schemes via?Small Universal Hitting Sets with?Short Remaining Path Lengthhere is a tight relationship between universal hitting sets and minimizers schemes, where minimizers schemes with low density (i.e., efficient schemes) correspond to universal hitting sets of small size. Local schemes are a generalization of minimizers schemes which can be used as replacement for mi作者: 不舒服 時間: 2025-3-29 22:56 作者: Filibuster 時間: 2025-3-30 02:03
978-3-030-45256-8Springer Nature Switzerland AG 2020作者: Gratuitous 時間: 2025-3-30 04:44
Research in Computational Molecular Biology978-3-030-45257-5Series ISSN 0302-9743 Series E-ISSN 1611-3349 作者: 容易懂得 時間: 2025-3-30 08:57
Lecture Notes in Computer Sciencehttp://image.papertrans.cn/r/image/827953.jpg作者: Aphorism 時間: 2025-3-30 14:08 作者: 圣人 時間: 2025-3-30 19:38
Strain-Aware Assembly of Genomes from?Mixed Samples Using Flow Variation?GraphsThe goal of strain-aware genome assembly is to reconstruct all individual haplotypes from a mixed sample at the strain level and to provide abundance estimates for the strains.作者: 值得贊賞 時間: 2025-3-30 21:30
Spectral Jaccard Similarity: A New Approach to Estimating Pairwise Sequence AlignmentsWe present Spectral Jaccard Similarity, a technique that combines min-hashing and spectral methods in order to efficiently estimate pairwise alignment between genomic reads.作者: Root494 時間: 2025-3-31 03:11 作者: 逗它小傻瓜 時間: 2025-3-31 08:21
Bayesian Non-parametric Clustering of Single-Cell Mutation ProfilesCancer is an evolutionary process characterized by the accumulation of mutations that drive tumor initiation, progression, and treatment resistance.作者: 東西 時間: 2025-3-31 12:32 作者: 口訣法 時間: 2025-3-31 13:47
