標(biāo)題: Titlebook: Receptor-Mediated Targeting of Drugs; G. Gregoriadis,G. Poste,A. Trouet Book 1984 Springer Science+Business Media New York 1984 biology.en [打印本頁(yè)] 作者: lumbar-puncture 時(shí)間: 2025-3-21 19:25
書(shū)目名稱Receptor-Mediated Targeting of Drugs影響因子(影響力)
書(shū)目名稱Receptor-Mediated Targeting of Drugs影響因子(影響力)學(xué)科排名
書(shū)目名稱Receptor-Mediated Targeting of Drugs網(wǎng)絡(luò)公開(kāi)度
書(shū)目名稱Receptor-Mediated Targeting of Drugs網(wǎng)絡(luò)公開(kāi)度學(xué)科排名
書(shū)目名稱Receptor-Mediated Targeting of Drugs被引頻次
書(shū)目名稱Receptor-Mediated Targeting of Drugs被引頻次學(xué)科排名
書(shū)目名稱Receptor-Mediated Targeting of Drugs年度引用
書(shū)目名稱Receptor-Mediated Targeting of Drugs年度引用學(xué)科排名
書(shū)目名稱Receptor-Mediated Targeting of Drugs讀者反饋
書(shū)目名稱Receptor-Mediated Targeting of Drugs讀者反饋學(xué)科排名
作者: macular-edema 時(shí)間: 2025-3-21 23:47
Long-Term Kinetics of Antibody-Toxin Conjugates Show Resistant Cells,ched its maximal inhibition of protein synthesis. OX-7-A was incubated at subsaturating concentrations with cells for 30 h and the survivors were then treated with a second addition of OX-7-A at the same concentration as the first. The survivors were inhibited by the second incubation only 5–20% as 作者: HALO 時(shí)間: 2025-3-22 04:25
The Use of Ricin a Chain-Containing Immunotoxins to Kill Neoplastic B Cells,d Pihl, in press). There is evidence that the B chain can also facilitate the translocation of the A chain through the membrane of the endocytic vesicle, possibly by forming a pore (Jansen, et al., 1982; Neville and Youle, 1982; Thorpe and Ross, 1982; Houston, 1982). In the cytoplasm, the A chain of作者: Introvert 時(shí)間: 2025-3-22 06:09
Development of Monoclonal Antibodies with Specificity for Human Epithelial Cells,terest. It is probably fair to say that most of the antibodies reacting with malignant epithelial cells which have been produced so far, are tumour-associated rather than tumour-specific and show a positive reaction with some other normal cells, usually epithelial in origin.作者: 使堅(jiān)硬 時(shí)間: 2025-3-22 11:51 作者: gruelling 時(shí)間: 2025-3-22 13:53 作者: 乞討 時(shí)間: 2025-3-22 17:54 作者: DOLT 時(shí)間: 2025-3-22 23:13
M. M. Ponpipom,R. L. Bugianesi,J. C. Robbins,T. W. Doebber,T. Y. Shenrom other education systems...Expertise in Mathematics Instruction. builds on its theoretical and methodological approach with contributions from international experts in the field. Additionally, a review of related research from mathematics education serves as an introduction to the new research in作者: progestogen 時(shí)間: 2025-3-23 03:11 作者: Goblet-Cells 時(shí)間: 2025-3-23 06:15
Sjur Olsnes,Kirsten Sandvig,Anders Sundan,Kristin Eiklid,Alexander Pihl researchers have tacitly conceived of mathematics teachers as either diagnosticians of students’ thinking, conductors of classroom discourse, architects of curriculum, or river guides who are flexible in the moments of teaching. An awareness of these images of expertise will help the field both rec作者: 褲子 時(shí)間: 2025-3-23 12:09 作者: 弄皺 時(shí)間: 2025-3-23 16:14
Vic Raso,Marylu Basalas literate in Li. The second language is frequently not acquired to the same extent as the first language, first language literacy influences the acquisition of L2 literacy in complex ways, and the use of writing in different L2 contexts differs widely. What does it mean, then, to be an expert write作者: 灌輸 時(shí)間: 2025-3-23 21:00
Richard J. Youle,David M. Neville Jr.s literate in Li. The second language is frequently not acquired to the same extent as the first language, first language literacy influences the acquisition of L2 literacy in complex ways, and the use of writing in different L2 contexts differs widely. What does it mean, then, to be an expert write作者: Dawdle 時(shí)間: 2025-3-24 00:00 作者: 蟄伏 時(shí)間: 2025-3-24 06:14
Ellen S. Vitetta,Jonathan W. Uhrs literate in Li. The second language is frequently not acquired to the same extent as the first language, first language literacy influences the acquisition of L2 literacy in complex ways, and the use of writing in different L2 contexts differs widely. What does it mean, then, to be an expert write作者: synchronous 時(shí)間: 2025-3-24 06:53 作者: goodwill 時(shí)間: 2025-3-24 12:19 作者: 踉蹌 時(shí)間: 2025-3-24 15:30 作者: CESS 時(shí)間: 2025-3-24 22:48
Gregory Gregoriadis,Judith Senior,Barbara Wolff,Christopher KirbyThese industry subsidized courses taken after medical school graduation are one- or two-week courses whose curriculum is to train recent medical school graduates how to function as surgeons. Patients deserve the work of professionals in and out of the operating room.?.Expertise in the Operating Room作者: Volatile-Oils 時(shí)間: 2025-3-25 00:13
G. B. Humphrey,L. V. Allen,R. Blackstock,P. C. Comp,L. E. De Bault,C. T. Esmon,A. Harriman,F. A. Holder Expertise von Lehrkr?ften rekonstruiert werden, die ihr Denken und Wahrnehmen leiten. Die daraus resultierenden Diagnose- und F?rderpraktiken tragen ma?geblich zu einem tieferen Verst?ndnis der Expertise bei und erm?glichen die Entwicklung konkreter gegenstandsspezifischer Designelemente für die作者: constitute 時(shí)間: 2025-3-25 05:48
Vicente J. Carideze und theoretische Schwerpunkte. Inzwischen haben sich die beiden Forschungszweige inhaltlich soweit voneinander entfernt, da? sie sich nun gegenseitig mit Ideen und Methoden befruchten k?nnen und teilweise auch wollen. Für Psychologen sind die neuesten Arbeiten der Künstlichen Intelligenz, insbeso作者: Bronchial-Tubes 時(shí)間: 2025-3-25 09:35
Robert M. Straubinger,Keelung Hong,Daniel S. Friend,Nejat Duzgunes,Demetrios Papahadjopoulostiken tragen ma?geblich zu einem tieferen Verst?ndnis der Expertise bei und erm?glichen die Entwicklung konkreter gegenstandsspezifischer Designelemente für die978-3-658-36076-4978-3-658-36077-1Series ISSN 2512-0506 Series E-ISSN 2512-1162 作者: 冷淡一切 時(shí)間: 2025-3-25 14:39 作者: 拖債 時(shí)間: 2025-3-25 18:24 作者: 用不完 時(shí)間: 2025-3-25 23:46 作者: 溝通 時(shí)間: 2025-3-26 02:39
NATO Science Series A:http://image.papertrans.cn/r/image/823557.jpg作者: 省略 時(shí)間: 2025-3-26 07:59
https://doi.org/10.1007/978-1-4684-4862-7biology; enzymes; pharmacology; protein; proteins; receptor作者: mortgage 時(shí)間: 2025-3-26 09:27 作者: 招募 時(shí)間: 2025-3-26 16:35 作者: 報(bào)復(fù) 時(shí)間: 2025-3-26 16:54 作者: Ancestor 時(shí)間: 2025-3-26 23:36
activation or by their inability to interact with or reach target sites efficiently. New trends in pharmacology empha- size the development of methods for the optimization of drug action, for instance by the delivery of drugs, enzymes, hormones, antigens, genetic material, ets. through carrier syste作者: infelicitous 時(shí)間: 2025-3-27 02:06
Drug Targeting in Human Cancer Chemotherapy,ough a covalent bond to macromolecular carriers which are recognized by receptors or antigens present at the cell surface of the target cells and thereafter endocytosed to allow the release of the drug after hydrolysis of the covalent linkage by lysosomal enzymes.作者: seduce 時(shí)間: 2025-3-27 08:18 作者: 民間傳說(shuō) 時(shí)間: 2025-3-27 11:18
Monoclonal Antibodies as Cell Targeted Carriers of Covalently and Non-Covalently Attached Toxins, active toxic portion, these components can be cleaved and isolated (Olsnes and Pihl, 1973). Thus, purified toxic subunits can be coupled to antibodies to produce highly selective cytotoxic agents which are devoid of residual toxin binding.作者: CHOP 時(shí)間: 2025-3-27 16:01
Endocytosis of Liposomes and Intracellular Fate of Encapsulated Molecules: Strategies for Enhanced ecently, several groups have shown that it is possible to couple covalently to the liposome surface a variety of ligands, such as immunoglobulins, to promote specificity of lipo-some-cell interaction and to increase the number of liposomes bound to or internalized by cells (Heath et al., 1980; Leserman et al., 1980; Heath et al., 1983).作者: 宴會(huì) 時(shí)間: 2025-3-27 18:30 作者: Servile 時(shí)間: 2025-3-28 02:00
The Use of Liposomes in Diagnostic Imaging,f, the route (including the administration route and the path between the site of administration and the final destination) and the target tissue. Drug carriers, route and target have specific chemical, physical and anatomical features that deserve special consideration.作者: Hyperplasia 時(shí)間: 2025-3-28 03:18
Drug Targeting in Human Cancer Chemotherapy,itable side effects resulting from an interaction of the drugs with non target cells and, on the other hand, enhance the pharmacological activity by increasing the proportion of the administered drug found within the target cells. Our conceptual approach to this problem consists in linking drugs thr作者: 詩(shī)集 時(shí)間: 2025-3-28 06:57
Toxic Conjugates of Epidermal Growth Factor and Asialofetuin, cell surface receptors and initiate a cascade of biological responses leading either to cell division or expression of a new phenotype as a consequence of ligand-receptor interactions. In many cases one of the most notable initial responses is ligand-induced endocytosis of the receptor-ligand compl作者: Nucleate 時(shí)間: 2025-3-28 11:12
Saccharide Receptor-Mediated Drug Delivery,ccepted that exposed sugar residues on glycoproteins serve as determinants for in-vivo (i.e., clearance) and in-vitro (i.e., uptake) recognition. Carbohydrate-mediated endocytosis in mammals has since become the subject of intensive studies.. Mammalian hepatic receptors are known to be specific for 作者: 即席演說(shuō) 時(shí)間: 2025-3-28 18:37
Study of the Transferrin Receptor Using a Cytotoxic Human Transferrin-Ricin a Chain Conjugate,ttachment of pure A chain to cell membranes has not been demonstrated (Raso, 1981), it is toxic at high concentrations indicating that cells can inefficiently internalize this 30,000 MW protein. Cytotoxicity is enhanced 10.–10.-fold however by recombining A chain either with its natural B chain subu作者: 財(cái)主 時(shí)間: 2025-3-28 22:33
How do Protein Toxins Kill Cells?,elated toxic proteins produced by bacteria and plants. The main reason why these toxins are used for this purpose is their extreme toxicity. This is due to the fact that the active moieties of the toxins possess enzymatic activity. A single molecule may inactivate components required for protein syn作者: BAIL 時(shí)間: 2025-3-29 02:41 作者: Emg827 時(shí)間: 2025-3-29 05:14
Monoclonal Antibodies as Cell Targeted Carriers of Covalently and Non-Covalently Attached Toxins,rable interest because of its therapeutic potential. Intact plant or bacterial toxins linked to antibodies may acquire some cell selectivity but because toxin binding sites are retained, non-specific toxicity can still occur. Since the binding region of such toxins is distinct from the enzymatically作者: 輪流 時(shí)間: 2025-3-29 09:40
Long-Term Kinetics of Antibody-Toxin Conjugates Show Resistant Cells, After this period, the surviving cells began growing again. The maximal rate of protein synthesis inactivation was one log inactivation each 10 h and was reached when the cell surface antigen was saturated with conjugate. Therefore, the maximal inactivation of one addition of conjugate over the 15 作者: 少量 時(shí)間: 2025-3-29 13:37
Significance of the Kinetics of Immunotoxin Cytotoxicity, have been described by several laboratories as cytotoxic agents with high specificity for their target cells.. However, there was great variation from high to low potency depending on the antigen-immunotoxin (IT) system used. The advantage of the I-A-Ts is their low non-specific toxicity in-vivo (L作者: growth-factor 時(shí)間: 2025-3-29 19:35
The Use of Ricin a Chain-Containing Immunotoxins to Kill Neoplastic B Cells,ts to apply this concept to the elimination of neoplastic and other target cells using antibodies coupled to toxic agents. A cell-binding antibody conjugated to a plant or bacterial toxin has been termed an “immunotoxin”. One such toxin, ricin, like most toxic proteins produced by bacteria and plant作者: 拘留 時(shí)間: 2025-3-29 22:23
Selective Cytotoxicity of Ricin a Chain-Anti Carcinoembryonic Antibody Conjugates to Human Adenocartion antigens (1, 2) and immunoglobulin on the surface of murine and human B cell leukemia cells (3–6). We have recently explored this approach utilizing antibodies directed against the carcinoembryonic antigen, CEA (7–9), a well described tumor-associated antigen of adult human solid malignancies.作者: 搖擺 時(shí)間: 2025-3-30 02:47 作者: Heretical 時(shí)間: 2025-3-30 06:24
Fate of Liposomes In Vivo: Control Leading to Targeting,iculoendothelial system (RES). Rate of uptake in particular tissues of the RES depends on vesicle size, surface charge and lipid composition, amount of liposomal lipid given, animal species and physiological state. For instance, a large vesicle size and/or a negative surface charge promote rapid upt作者: 仲裁者 時(shí)間: 2025-3-30 09:36 作者: Cabg318 時(shí)間: 2025-3-30 15:31
Endocytosis of Liposomes and Intracellular Fate of Encapsulated Molecules: Strategies for Enhanced materials and deliver them, functionally intact, to particular in-vivo or in-vitro compartments. Liposomes are adaptable to the requirements of a wide range of experimental conditions, since it is possible to alter such parameters as liposome size, surface charge, bilayer fluidity, and stability. R作者: 船員 時(shí)間: 2025-3-30 18:46 作者: 執(zhí) 時(shí)間: 2025-3-30 21:03 作者: 獸皮 時(shí)間: 2025-3-31 04:42
The Use of Liposomes in Diagnostic Imaging,ructure. Using drug carriers the pharmacokinetics can be changed to make possible the selective drug delivery to normal and pathological tissues. Besides protecting the drug, the carrier facilitates the movement of the drug across anatomic and biochemical barriers to selected cells, tissues or organ作者: Visual-Acuity 時(shí)間: 2025-3-31 08:44
Book 1984 or by their inability to interact with or reach target sites efficiently. New trends in pharmacology empha- size the development of methods for the optimization of drug action, for instance by the delivery of drugs, enzymes, hormones, antigens, genetic material, ets. through carrier systems selecti作者: Creditee 時(shí)間: 2025-3-31 10:46
How do Protein Toxins Kill Cells?,ue to the fact that the active moieties of the toxins possess enzymatic activity. A single molecule may inactivate components required for protein synthesis more rapidly than the cell can produce new ones and hence kill the cell in the course of a few hours.作者: Agnosia 時(shí)間: 2025-3-31 16:30
Significance of the Kinetics of Immunotoxin Cytotoxicity,m high to low potency depending on the antigen-immunotoxin (IT) system used. The advantage of the I-A-Ts is their low non-specific toxicity in-vivo (LD/50 in mice 20mg/kg),. which will allow their utilization in human patients in the near future.作者: Complement 時(shí)間: 2025-3-31 20:08
