標(biāo)題: Titlebook: Reactive Oxygen Species; Network Pharmacology Harald H. H. W. Schmidt,Pietro Ghezzi,Antonio Cuad Book 2021 Springer Nature Switzerland AG 2 [打印本頁(yè)] 作者: HAVEN 時(shí)間: 2025-3-21 19:13
書目名稱Reactive Oxygen Species影響因子(影響力)
作者: 表示向前 時(shí)間: 2025-3-21 23:42
These challenges also relate to their specificity, resulting from the dual connection of the two inter-related systems: the business and the family. This connection leads family enterprises to simultaneously combine in their functioning the implementation of economic goals and the goals of the famil作者: scoliosis 時(shí)間: 2025-3-22 02:49 作者: 叢林 時(shí)間: 2025-3-22 07:27 作者: 等級(jí)的上升 時(shí)間: 2025-3-22 11:24 作者: scotoma 時(shí)間: 2025-3-22 12:55 作者: JOT 時(shí)間: 2025-3-22 17:56
Jie Zhang,Zhi-Wei Ye,Yvonne Janssen-Heininger,Danyelle M. Townsend,Kenneth D. Tew for chocolate, or France for wine. Germany has built such a strong country image for engineering and car manufacturing — so much that French car maker Citro?n created a parody TV ad campaign in 2008 claiming its C5 model was “unmistakably German.” While this is a rather funny anecdote, it demonstra作者: Insensate 時(shí)間: 2025-3-23 00:42 作者: Facilities 時(shí)間: 2025-3-23 02:37 作者: BOOR 時(shí)間: 2025-3-23 06:56
Pablo Duarte,Antonio Cuadrado,Rafael Leóndes Unternehmens beigemessen wird (vgl. .). Die vielfach klein- und mittelst?ndische Pr?gung der Tourismusbranche verst?rkt die Bedeutung des Unternehmers/der Führungskraft in touristischen Beherbergungsbetrieben im Hinblick auf den Unternehmenserfolg zus?tzlich. Nicht nur Manager in Gro?unternehmen作者: 討好女人 時(shí)間: 2025-3-23 11:38
Jala Soubhye,Paul G. Furtmüller,Francois Dufrasne,Christian Obingerdes Unternehmens beigemessen wird (vgl. .). Die vielfach klein- und mittelst?ndische Pr?gung der Tourismusbranche verst?rkt die Bedeutung des Unternehmers/der Führungskraft in touristischen Beherbergungsbetrieben im Hinblick auf den Unternehmenserfolg zus?tzlich. Nicht nur Manager in Gro?unternehmen作者: conduct 時(shí)間: 2025-3-23 15:57
enzarten auf die Entwicklungsgeschwindigkeit junger Technologieunternehmen (JTUs). Die Entwicklungsgeschwindigkeit leiten wir aus einem für diese Arbeit konzipierten Entwicklungsmodell ab, anhand dessen sich das Entwicklungsstadium der JTUs spezifizieren l?sst. Unsere Untersuchung der Zusammenh?nge 作者: companion 時(shí)間: 2025-3-23 19:12 作者: GLIDE 時(shí)間: 2025-3-23 22:36 作者: 使無(wú)效 時(shí)間: 2025-3-24 03:42
Keith M. Channonenzarten auf die Entwicklungsgeschwindigkeit junger Technologieunternehmen (JTUs). Die Entwicklungsgeschwindigkeit leiten wir aus einem für diese Arbeit konzipierten Entwicklungsmodell ab, anhand dessen sich das Entwicklungsstadium der JTUs spezifizieren l?sst. Unsere Untersuchung der Zusammenh?nge 作者: Gastric 時(shí)間: 2025-3-24 06:57
hat many entrepreneurs share. They tend to be good problem-solvers, innovative, they take risks, and they can mobilise people and resources to make things happen. However, finding the blueprint for making an entrepreneur can be quite difficult. In addition, many students do not want to become entrep作者: grieve 時(shí)間: 2025-3-24 14:32 作者: Eructation 時(shí)間: 2025-3-24 15:52
Mahmoud H. Elbatreek,Hermann Mucke,Harald H. H. W. Schmidt作者: 蕁麻 時(shí)間: 2025-3-24 20:54 作者: 公共汽車 時(shí)間: 2025-3-25 01:56
Demystifying Oxidative Stresss apparently wrong. Physiological ROS signalling may become dysfunctional or a disease trigger by at least five mechanisms: a physiological source may appear at an unphysiological site, a physiological source may be underactivated (less common) or overactivated (more common), a new source may appear作者: 永久 時(shí)間: 2025-3-25 06:17
Oxidants in Physiological Processesventions that target persistently altered ROS levels should include both selective inhibition of a specific source of primary ROS and careful consideration of a targeted pro-oxidant approach, an avenue that is still underdeveloped. Both strategies require attention to redox dynamics in complex cellu作者: ungainly 時(shí)間: 2025-3-25 08:25
Network Medicine-Based Unbiased Disease Modules for Drug and Diagnostic Target Identification in ROSringent subnet participation degree (SPD) of 0.4, hub nodes excluded. This resulted in 12 distinct human interactome-based ROS signalling modules, while 8 proteins remaining unconnected. This ROSome is in sharp contrast to commonly used highly curated and integrated KEGG, HMDB or WikiPathways. These作者: deviate 時(shí)間: 2025-3-25 13:44 作者: brother 時(shí)間: 2025-3-25 15:50 作者: 摸索 時(shí)間: 2025-3-25 22:33
Nitric Oxide Synthase Inhibitors into the Clinic at Lasteclining in clinical relevance or hold promise but need yet to enter formal therapeutic guidelines, respectively. Nevertheless, NOS inhibition in situations of NO overproduction often jointly with enhanced superoxide (or hydrogen peroxide production) still holds promise, but most likely only in acut作者: 別炫耀 時(shí)間: 2025-3-26 00:23 作者: Thymus 時(shí)間: 2025-3-26 05:34 作者: palette 時(shí)間: 2025-3-26 10:05
Effects of Mammalian Thioredoxin Reductase Inhibitorscancer efficacy. The observed increases in antioxidant capacity upon inhibition of TrxR in normal cells are in part dependent upon activation of the Nrf2 transcription factor, while exaggerated ROS levels in cancer cells can be explained by a non-oncogene addiction of cancer cells to TrxR1 due to th作者: 神化怪物 時(shí)間: 2025-3-26 13:36
Cardiovascular Therapeutic Potential of the Redox Siblings, Nitric Oxide (NO?) and Nitroxyl (HNO), icy of current therapies, such as nitrosovasodilators. As such, alternate therapies are sought. This review will discuss the impact of ROS dysregulation on the therapeutic utility of NO? and its redox sibling, nitroxyl (HNO)..Both nitric oxide (NO) and nitroxyl (HNO) donors signal through soluble gua作者: 小卷發(fā) 時(shí)間: 2025-3-26 19:47
Tetrahydrobiopterin and Nitric Oxide Synthase Recouplerstor, tetrahydrobiopterin (BH4). The duality of NOS functions as enzymes that generate both NO and ROS under different regulatory states has emerged as an important pathophysiologic mechanism, and is a potential therapeutic target, via agents that can maintain or restore NOS coupling, for example via作者: Abutment 時(shí)間: 2025-3-26 21:04
Soluble Guanylate Cyclase Stimulators and Activators heme-containing and oxidized, heme-free sGC, respectively, which results in an increase in cGMP production. The action of sGC stimulators at the heme-containing enzyme is independent of NO but is enhanced in the presence of NO whereas the sGC activators interact with the heme-free form of sGC. Thes作者: vascular 時(shí)間: 2025-3-27 05:01
Book 2021emain the same and this book will thus become, and for many years remain, the leadingreference for ROSopathies and their treatment by network pharmacology.??. .Chapter "Soluble Guanylate Cyclase Stimulators and Activators" is available open access under a Creative Commons Attribution 4.0 Internation作者: TOXIN 時(shí)間: 2025-3-27 07:39
0171-2004 ence for ROSopathies and their treatment by network pharmacology.??. .Chapter "Soluble Guanylate Cyclase Stimulators and Activators" is available open access under a Creative Commons Attribution 4.0 Internation978-3-030-68512-6978-3-030-68510-2Series ISSN 0171-2004 Series E-ISSN 1865-0325 作者: formula 時(shí)間: 2025-3-27 12:21
Book 2021exemplified by the failure of the so-called anti-oxidants. This book is a game changer for the field and many clinical areas such as cardiology and neurology. The term ‘oxidative stress’ is abandoned and replaced with a systems medicine and network pharmacology-based mechanistic approach to disease.作者: Decrepit 時(shí)間: 2025-3-27 16:20 作者: 戲法 時(shí)間: 2025-3-27 19:12 作者: conception 時(shí)間: 2025-3-27 22:10 作者: 燈絲 時(shí)間: 2025-3-28 04:45
Development of Telintra as an Inhibitor of Glutathione S-Transferase Pn certain tumors and is over-expressed in cancer drug resistance. It has diverse cellular functions that include, thiolase activities with small electrophilic agents or susceptible cysteine residues on the protein to mediate S-glutathionylation, and chaperone binding with select protein kinases. Pre作者: Memorial 時(shí)間: 2025-3-28 06:22 作者: Digest 時(shí)間: 2025-3-28 12:53
NOX Inhibitors: From Bench to Naxibs to Bedsideions. Pathophysiology arises when ROS are generated either in excess or in cell types or subcellular locations that normally do not produce ROS or when non-physiological types of ROS (e.g., superoxide instead of hydrogen peroxide) are formed. In the latter scenario, antioxidants were considered as t作者: Hdl348 時(shí)間: 2025-3-28 15:25
Nitric Oxide Synthase Inhibitors into the Clinic at Last nitrogen or reactive nitrogen/oxygen species) stirred great hopes. Clinical applications, however, have so far pertained exclusively to the downstream signaling of cGMP enhancing drugs such as phosphodiesterase inhibitors and soluble guanylate cyclase stimulators. All clinical attempts, so far, to 作者: 諷刺滑稽戲劇 時(shí)間: 2025-3-28 21:57
Xanthine Oxidoreductase Inhibitors oxidase inhibitor, Allopurinol has been shown to have other beneficial effects such as a reduction in vascular reactive oxygen species and mechano-energetic uncoupling. This chapter discusses these properties and their relevance to human pathophysiology with a focus on Allopurinol as well as newer 作者: 愛花花兒憤怒 時(shí)間: 2025-3-28 23:28
Monoamine Oxidase Inhibitors: From Classic to New Clinical Approachesfor several disorders and along the last 70 years a wide variety of MAO inhibitors have been developed as successful drugs for the treatment of complex diseases, being the first drugs approved for depression in the late 1950s. The discovery of two MAO isozymes (MAO-A and B) with different substrate 作者: 災(zāi)禍 時(shí)間: 2025-3-29 03:46
Inhibition of Myeloperoxidaseunique activity is its ability to use chloride as a cosubstrate with hydrogen peroxide to generate chlorinating oxidants such as hypochlorous acid, a potent antimicrobial agent. However, chronic MPO activation can lead to indiscriminate protein modification causing tissue damage, and has been associ作者: hereditary 時(shí)間: 2025-3-29 08:00
Effects of Mammalian Thioredoxin Reductase Inhibitors in turn help to keep thioredoxins (TXN, Trx) and further downstream targets reduced. Due to a wide range of functions in antioxidant defense, cell proliferation, and redox signaling, strong cellular aberrations are seen upon the targeting of TrxR enzymes by inhibitors. However, such inhibition can 作者: 窗簾等 時(shí)間: 2025-3-29 13:16
Cardiovascular Therapeutic Potential of the Redox Siblings, Nitric Oxide (NO?) and Nitroxyl (HNO), i. ROS such as superoxide (?O.), hydrogen peroxide (H.O.), hydroxyl (OH?) and peroxynitrite (ONOO.) have a marked impact on cardiovascular function, contributing to the vascular impairment and cardiac dysfunction associated with diseases such as angina, hypertension, diabetes and heart failure. Centr作者: 在駕駛 時(shí)間: 2025-3-29 16:51 作者: archetype 時(shí)間: 2025-3-29 22:34 作者: lattice 時(shí)間: 2025-3-30 00:24
Development of Telintra as an Inhibitor of Glutathione S-Transferase Pclinical and clinical testing of a nanomolar inhibitor of GSTP, TLK199 (Telintra; Ezatiostat) has indicated a role for the enzyme in hematopoiesis and utility for the drug in the treatment of patients with myelodysplastic syndrome.作者: Isthmus 時(shí)間: 2025-3-30 05:57
Inhibition of Myeloperoxidase differences with the other homologous human peroxidases, various rational and high-throughput screening attempts were performed in developing specific irreversible and reversible inhibitors. The most prominent candidates as well as MPO inhibitors already studied in clinical trials are introduced and discussed.作者: 留戀 時(shí)間: 2025-3-30 11:55 作者: 鐵塔等 時(shí)間: 2025-3-30 13:55 作者: 樂意 時(shí)間: 2025-3-30 20:27
en citizens’ opportunities to develop and operate their own businesses ceased to be restricted due to ideological reasons, economic growth has become unprecedented in the Polish history. Thanks to this growth, the Polish economy has transformed into a developing market from an underdeveloped one, gr作者: Adj異類的 時(shí)間: 2025-3-30 21:44
Pietro Ghezzi,Arshag D. Mooradianen citizens’ opportunities to develop and operate their own businesses ceased to be restricted due to ideological reasons, economic growth has become unprecedented in the Polish history. Thanks to this growth, the Polish economy has transformed into a developing market from an underdeveloped one, gr作者: APRON 時(shí)間: 2025-3-31 02:00 作者: 祖先 時(shí)間: 2025-3-31 06:04
Cristian Nogales,Alexander G. B. Gr?nning,Sepideh Sadegh,Jan Baumbach,Harald H. H. W. Schmidtprotect British products from foreign copycats of lower quality. And still today, the label “Made in… ” — despite its brevity — likely has one of the most significant impacts on people’s perceptions, value attribution and purchasing behavior across a wide range of product categories. This is true fr作者: 情節(jié)劇 時(shí)間: 2025-3-31 12:02
