標(biāo)題: Titlebook: Rational Drug Design; Methods and Protocol Yi Zheng Book 2012 Springer Science+Business Media New York 2012 ATP binding.GTPases.Structure b [打印本頁(yè)] 作者: ANNOY 時(shí)間: 2025-3-21 17:53
書目名稱Rational Drug Design影響因子(影響力)
書目名稱Rational Drug Design影響因子(影響力)學(xué)科排名
書目名稱Rational Drug Design網(wǎng)絡(luò)公開(kāi)度
書目名稱Rational Drug Design網(wǎng)絡(luò)公開(kāi)度學(xué)科排名
書目名稱Rational Drug Design被引頻次
書目名稱Rational Drug Design被引頻次學(xué)科排名
書目名稱Rational Drug Design年度引用
書目名稱Rational Drug Design年度引用學(xué)科排名
書目名稱Rational Drug Design讀者反饋
書目名稱Rational Drug Design讀者反饋學(xué)科排名
作者: 進(jìn)取心 時(shí)間: 2025-3-21 20:52
Jacek Biesiada,Aleksey Porollo,Jaroslaw Meller book if very accurate metal-alkyl bond dissociation enthalpy data were available, which, together with the enthalpies of formation of the parent organometallic molecules and of the organometallic fragments (produced upon dissocia-tion of the metal-alkyl bonds), would lead to the enthalpies of forma作者: 許可 時(shí)間: 2025-3-22 02:46 作者: addition 時(shí)間: 2025-3-22 06:03
Xun Shang,Yi Zhenghod was reasonably successful. It is limited in a major way if molecules contain strain, because the bond additivities do not in themselves include such strain. However, if the strain is independently determined, it can be added into the calculation. This was done by hand methods years ago by simply作者: 一再困擾 時(shí)間: 2025-3-22 12:37 作者: Tremor 時(shí)間: 2025-3-22 14:44 作者: 法律 時(shí)間: 2025-3-22 17:02
Julien Viaud,Jeffrey R. Petersonf einen festgesetzten Prozentsatz des Wirkstromverbrauchs beschr?nken bzw. den durchschnittlichen Leistungsfaktor in Verbindung mit der Wirkleistungsspitze als Grundlage für die Ermittlung der zu verrechnenden Scheinleistungsspitze verwenden. Der Blindstrombedarf der Industriebetriebe liegt aber dur作者: 無(wú)畏 時(shí)間: 2025-3-22 21:29 作者: 憤怒歷史 時(shí)間: 2025-3-23 05:23
Nathalie Bouquier,Sylvie Fromont,Anne Debant,Susanne Schmidtdungen, Affekte und Willens?u?erungen, die auf krankhaften Vorstellungen beruhen. Es ist verst?ndlich, da? derartige Symptome nur auftreten k?nnen, wenn ein konstitutionelles Ueberwiegen der sekund?ren Funktion vorhanden ist, wenn also Hyperfunktion von S besteht. Es handelt sich hier um die gew?hnl作者: tenuous 時(shí)間: 2025-3-23 08:15 作者: 參考書目 時(shí)間: 2025-3-23 12:53 作者: induct 時(shí)間: 2025-3-23 16:37 作者: 悄悄移動(dòng) 時(shí)間: 2025-3-23 18:57
Rational Drug Design978-1-62703-008-3Series ISSN 1064-3745 Series E-ISSN 1940-6029 作者: animated 時(shí)間: 2025-3-23 23:08 作者: 懦夫 時(shí)間: 2025-3-24 05:52
https://doi.org/10.1007/978-1-62703-008-3ATP binding; GTPases; Structure based virtual screening; anti-sense microRNA; drug discovery; drug resist作者: 可觸知 時(shí)間: 2025-3-24 10:35 作者: 圖畫文字 時(shí)間: 2025-3-24 12:18
Virtual Ligand Screening Combined with NMR to Identify Dvl PDZ Domain Inhibitors Targeting the Wnt Virtual ligand screening is a powerful technique to identify potential hits of targets and to increase hit rates. Here, we describe how we used this technique combined with NMR .N HSQC experiments to obtain small molecules that bind to the PDZ domain of Dvl targeting the Wnt signaling pathway.作者: genesis 時(shí)間: 2025-3-24 18:14
Determination of the Kinetics and Thermodynamics of Ligand Binding to a Specific Inactive ConformatRecent interest in inactive kinase conformations has generated the need to develop new biochemical tools to study them. Here, we describe the use of a fluorescent probe that selectively and potently binds to a specific inactive conformation of protein kinases. This allows for the thermodynamics and kinetics of ligand binding to be determined.作者: transplantation 時(shí)間: 2025-3-24 20:47
Yi ZhengAids scienctist in further study of rational drug design.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts.Includes suppleme作者: ungainly 時(shí)間: 2025-3-25 01:28 作者: 天然熱噴泉 時(shí)間: 2025-3-25 04:06
Random Mutagenesis of Peptide Aptamers as an Optimization Strategy for Inhibitor Screening,pproach, which has proven valid and efficient, is that stronger interaction in yeast will also lead to stronger inhibition. Our optimization method is effective, without loss of specificity, which is of a great importance for the discovery of inhibitors that target specific protein–protein interacti作者: Yourself 時(shí)間: 2025-3-25 10:48 作者: ARENA 時(shí)間: 2025-3-25 13:35 作者: 協(xié)議 時(shí)間: 2025-3-25 18:02
1064-3745 eproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls..?.Authoritative and practical, .Rational Drug Design: Methods and Protocols .seeks to aid scientists in the further study of rational drug design and future drug discovery..978-1-4939-5900-6978-1-62703-008-3Series ISSN 1064-3745 Series E-ISSN 1940-6029 作者: conception 時(shí)間: 2025-3-25 22:35
Valerie Hindie,Laura A. Lopez-Garcia,Ricardo M. Biondi作者: observatory 時(shí)間: 2025-3-26 01:31 作者: 供過(guò)于求 時(shí)間: 2025-3-26 08:08
he US National Institute of Standards and Technology. We trust the other contributors to this volume — and the reader alike — will not take umbrage or take flight at our choice, for we are fully confident that quantitatively little is changed, and qualitatively almost nothing is affected, by our cho作者: 哭得清醒了 時(shí)間: 2025-3-26 09:28
Jacek Biesiada,Aleksey Porollo,Jaroslaw Mellere other way around: organometallic thermochemists often . thermochemical data of organic free radicals to derive metal-ligand bond dissociation enthalpy values. In other words, the energetics of organometallic molecules may be regarded as an applica-tion example of the energetics of free radicals. T作者: 憤怒事實(shí) 時(shí)間: 2025-3-26 14:35
Jufang Shan,Jie J. Zheng is a “weak” bond. This, in turn, is related to bond order: an interatomic bond of high order is both shorter and stronger than a bond of lower order between the same two elements. There is a lot of reliable experimental evidence to support these principles when elements of the first short period (n作者: 襲擊 時(shí)間: 2025-3-26 18:52 作者: 言外之意 時(shí)間: 2025-3-26 22:27
Wenyong Tong,Tara Sprules,Kalle Gehring,H. Uri Saragovithods. Either way, we can sum this together with ordinary bond energy terms and calculate the heats of formation of molecules. The question is, how general is this, and how accurate?.We have carried out these methods in some detail for saturated hydrocarbons, and are extending the methods like vario作者: 勉強(qiáng) 時(shí)間: 2025-3-27 01:44 作者: 認(rèn)識(shí) 時(shí)間: 2025-3-27 09:21
Julien Viaud,Jeffrey R. Petersondie aus anderen Gründen ohnehin Synchronmaschinen einsetzen. Selbst in diesen Betrieben wird man jedoch meist zus?tzlich noch Kondensatoren zur Blindstromkompensation einsetzen, die sich durch ihre geringen Beschaffungskosten, den Wegfall der Wartung, ger?uschlosen Betrieb, hohe Lebensdauer, Aufteil作者: Exhilarate 時(shí)間: 2025-3-27 13:30
Anne Blangy,Philippe Forte Forschungsstelle für Energiewirtschaft macht bei ihren Untersuchungen in den Betrieben der verschiedensten Industriezweige immer wieder die Erfahrung, da? die innerbetrieblichen Stromverteilungen unwirtschaftlich betrieben werden, was insbesondere für die kleineren und mittleren Betriebe zutrifft, in denen 978-3-663-00482-0978-3-663-02395-1作者: 克制 時(shí)間: 2025-3-27 16:40
Nathalie Bouquier,Sylvie Fromont,Anne Debant,Susanne Schmidt bezeichnen und damit in Gegensatz zu den prim?ren Symptomen zu setzen. Die prim?ren Halluzinationen, Affekte und Willens?u?erungen k?nnen reproduzierte Elemente enthalten, die prim?re Wahnidee in unserem Sinne mu? sogar überwiegend Aeu?erung der sekund?ren Funktion sein, sie sind aber nie hysterisc作者: 無(wú)王時(shí)期, 時(shí)間: 2025-3-27 21:33 作者: arthrodesis 時(shí)間: 2025-3-27 22:45
Chinavenmeni S. Velu,H. Leighton Grimesd Grenzen des Einsatzes werden diskutiert; alle Energiequellen werden sodann nach Definition eines energetischen Erntefaktors miteinander verglichen. Die Speicher- und Transportm?glichkeiten und - hiermit eng verbunden - die Handlungsspielr?ume rationellen Umgangs mit den diversen Formen der Energie作者: 枕墊 時(shí)間: 2025-3-28 05:50
Book 2012oting and avoiding known pitfalls..?.Authoritative and practical, .Rational Drug Design: Methods and Protocols .seeks to aid scientists in the further study of rational drug design and future drug discovery..作者: 誓言 時(shí)間: 2025-3-28 09:13 作者: Clinch 時(shí)間: 2025-3-28 10:25 作者: 一條卷發(fā) 時(shí)間: 2025-3-28 14:47
Affinity Purification of Protein Kinases that Adopt a Specific Inactive Conformation,irements for adopting this conformation are still poorly understood. Here, we describe a general method for enriching DFG-out adopting kinases from cell lysates with an affinity resin that contains a general ligand that specifically recognizes this inactive form.作者: 不再流行 時(shí)間: 2025-3-28 19:19 作者: 動(dòng)作謎 時(shí)間: 2025-3-29 02:59
On Setting Up and Assessing Docking Simulations for Virtual Screening,lining experimental efforts in that regard. In this chapter, we describe specific software packages and protocols that can be used to efficiently set up a computational screening using a library of compounds and a docking program. We also discuss consensus- and clustering-based approaches that can b作者: 大猩猩 時(shí)間: 2025-3-29 04:20
Rational Design of Rho GTPase-Targeting Inhibitors, Virtual screening of compounds that fit into surface grooves of RhoA known to be critical for guanine nucleotide exchange factor (GEF) interaction produced chemical candidates with minimized docking energy. Subsequent screening for inhibitory activity of RhoA binding to the Rho-GEF, LARG, identifie作者: agenda 時(shí)間: 2025-3-29 09:17
Rational Design of Peptide Ligands Against a Glycolipid by NMR Studies,e GD2 and of GD2 bound to anti-GD2 mAb 3F8 were resolved by saturation transfer difference nuclear magnetic resonance and molecular modeling. Then small molecule cyclic peptide ligands that bind to GD2 selectively were designed, and shown to affect GD2-mediated signal transduction. The solution stru作者: 印第安人 時(shí)間: 2025-3-29 11:29 作者: 取之不竭 時(shí)間: 2025-3-29 16:54
Identification of Allosteric Inhibitors of p21-Activated Kinase,cuous inhibition of additional unintended kinase targets. Allosteric inhibitors that target less conserved regions of protein kinases represent an alternative approach that may provide more selective kinase inhibition. In this report, protocols are provided for the screening and identification of Pa作者: subordinate 時(shí)間: 2025-3-29 22:13
Using a Modified Yeast Two-Hybrid System to Screen for Chemical GEF Inhibitors,that over-activation of Ras-like pathways participates in the development of many cancer types. In particular, GTPases of the Rho family control cell adhesion, survival, motility, and invasion, cell properties dysregulated in most cancer types. Rho activation is triggered by RhoGEFs, most of which f作者: 祝賀 時(shí)間: 2025-3-30 00:40
Random Mutagenesis of Peptide Aptamers as an Optimization Strategy for Inhibitor Screening,pplied to a variety of different targets. Because of the screening method in cells and the highly combinatorial libraries available, this approach yields rapidly highly specific candidate inhibitors. Once a hit peptide has been identified, its interaction strength and affinity towards its target pro作者: 想象 時(shí)間: 2025-3-30 06:56 作者: vitreous-humor 時(shí)間: 2025-3-30 08:27 作者: 細(xì)微的差異 時(shí)間: 2025-3-30 14:30
Affinity Purification of Protein Kinases that Adopt a Specific Inactive Conformation,onserved in all kinases, the inactive DFG-out conformation appears to be accessible to only certain kinases. This inactive conformation has been successfully targeted with highly selective kinase inhibitors, including the cancer drugs imatinib and sorafenib. However, the structural and sequence requ作者: 細(xì)節(jié) 時(shí)間: 2025-3-30 19:34 作者: 粗野 時(shí)間: 2025-3-31 00:45 作者: 浸軟 時(shí)間: 2025-3-31 02:51 作者: 借喻 時(shí)間: 2025-3-31 07:07 作者: 舊石器 時(shí)間: 2025-3-31 12:44
Mouse Models for Tumor Metastasis,ntaneous metastasis mouse model, 4T1 mouse breast tumor cells are injected into the mammary gland of host mice and the metastasis of 4T1 tumor cells into the lung are examined with a colonogenic assay. In the second experimental metastasis mouse model, luciferase-labeled MDA-MB-231 human breast tumo作者: lesion 時(shí)間: 2025-3-31 16:35 作者: BILL 時(shí)間: 2025-3-31 18:07
Purification and Specific Assays for Measuring APE-1 Endonuclease Activity,celerated by the use of high-throughput screening. Nevertheless, potential inhibitors must be tested in other counterscreens to validate their selectivity for APE-1. Here, we describe in-depth protocols for APE-1 purification and development of assays specific for APE-1 endonuclease activity.作者: 爭(zhēng)論 時(shí)間: 2025-3-31 22:20
An In Vitro Screening to Identify Drug-Resistant Mutations for Target-Directed Chemotherapeutic Ageening strategy to identify the spectrum of resistance-conferring mutations, which has helped in designing the next-generation BCR/ABL inhibitors such as Nilotinib, Dasatinib, and Ponatinib. Here we provide a detailed methodology for the screen, which can be generally applied to any drug–target pair.作者: 優(yōu)雅 時(shí)間: 2025-4-1 01:51 作者: Celiac-Plexus 時(shí)間: 2025-4-1 07:59 作者: hauteur 時(shí)間: 2025-4-1 11:25 作者: Memorial 時(shí)間: 2025-4-1 18:11 作者: Anonymous 時(shí)間: 2025-4-1 22:20 作者: NEG 時(shí)間: 2025-4-2 00:44
Image Analysis by Wavelet-Type Transforms: Group Theoretic Approach,issibility condition of a mother wavelet-type transform. The following special cases of interest in image representation and in biological and computer vision are discussed: 2-and 3-D rigid motion, similarity and Lorentzian groups, and 2-D projective groups obtained from 3-D camera rotation.作者: amnesia 時(shí)間: 2025-4-2 05:57
2191-8112 approaches.Presents information about various systems, whicThis book shows how machine learning can detect moving objects in a digital video stream. The authors present different background subtraction approaches, foreground segmentation, and object tracking approaches to accomplish this. They also
