標(biāo)題: Titlebook: Ras Superfamily Small G Proteins: Biology and Mechanisms 2; Transport Alfred Wittinghofer Book 2014 Springer International Publishing Switz [打印本頁] 作者: CHAFF 時間: 2025-3-21 18:40
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作者: 表示向前 時間: 2025-3-21 22:16
alike.Includes traditional questions, more recent developmeThis encyclopedia covers all topics in the philosophy of law and social philosophy, including the history, theory, and leading theorists in both fields.? Featuring specially commissioned entries by an international team of the world‘s most 作者: 巧思 時間: 2025-3-22 01:59
Roger S. Goody,Yaowen Wu,Aymelt Itzen alike.Includes traditional questions, more recent developmeThis encyclopedia covers all topics in the philosophy of law and social philosophy, including the history, theory, and leading theorists in both fields.? Featuring specially commissioned entries by an international team of the world‘s most 作者: 出生 時間: 2025-3-22 06:36
Marnix Wieffer,Marisa P. McShane,Marino Zerial alike.Includes traditional questions, more recent developmeThis encyclopedia covers all topics in the philosophy of law and social philosophy, including the history, theory, and leading theorists in both fields.? Featuring specially commissioned entries by an international team of the world‘s most 作者: 會犯錯誤 時間: 2025-3-22 11:39
Lena Katharina Oesterlin,Olena Pylypenko,Bruno Goud alike.Includes traditional questions, more recent developmeThis encyclopedia covers all topics in the philosophy of law and social philosophy, including the history, theory, and leading theorists in both fields.? Featuring specially commissioned entries by an international team of the world‘s most 作者: Delude 時間: 2025-3-22 13:02 作者: 毗鄰 時間: 2025-3-22 20:32 作者: Melodrama 時間: 2025-3-23 00:15 作者: FEIGN 時間: 2025-3-23 02:19
Murray Stewart alike.Includes traditional questions, more recent developmeThis encyclopedia covers all topics in the philosophy of law and social philosophy, including the history, theory, and leading theorists in both fields.? Featuring specially commissioned entries by an international team of the world‘s most 作者: Insatiable 時間: 2025-3-23 07:49 作者: 沉思的魚 時間: 2025-3-23 11:18 作者: 宇宙你 時間: 2025-3-23 14:41 作者: 得意牛 時間: 2025-3-23 18:58
Frank Adolf,Felix T. Wieland alike.Includes traditional questions, more recent developmeThis encyclopedia covers all topics in the philosophy of law and social philosophy, including the history, theory, and leading theorists in both fields.? Featuring specially commissioned entries by an international team of the world‘s most 作者: sclera 時間: 2025-3-23 22:30 作者: groggy 時間: 2025-3-24 05:40
Shigeru Hashimoto,Ari Hashimoto,Hirokazu Sugino,Ayumu Yoshikawa,Haruka Handa,Masanao Yoshino,Yutaro alike.Includes traditional questions, more recent developme.This encyclopedia covers all topics in the philosophy of law and social philosophy, including the history, theory, and leading theorists in both fields.? Featuring specially commissioned entries by an international team of the world‘s most作者: jagged 時間: 2025-3-24 10:09
alike.Includes traditional questions, more recent developme.This encyclopedia covers all topics in the philosophy of law and social philosophy, including the history, theory, and leading theorists in both fields.? Featuring specially commissioned entries by an international team of the world‘s most作者: lethargy 時間: 2025-3-24 13:23 作者: FISC 時間: 2025-3-24 17:55 作者: 蕁麻 時間: 2025-3-24 22:03 作者: 規(guī)范要多 時間: 2025-3-25 01:58
Rab Proteins and the Organization of Organelle Membrane Domainsout we will highlight how these proteins are regulated such as via feedback and feed-forward loops to create cascades. Finally, we propose that signaling domains on organelles are also coordinated by Rab GTPases.作者: Pepsin 時間: 2025-3-25 04:44 作者: overhaul 時間: 2025-3-25 08:35 作者: atopic-rhinitis 時間: 2025-3-25 15:22 作者: 健壯 時間: 2025-3-25 16:47 作者: plasma-cells 時間: 2025-3-25 20:28 作者: Bereavement 時間: 2025-3-26 03:11
Prenylation of RabGTPases, Their Delivery to Membranes, and Rab Recyclinge able to interact with membranes. Here, we review the basic mechanism of geranlygeranylation and then address the still unsolved question of how prenylated Rabs are delivered to specific membranes. The evidence reviewed leads to a model in which specifically localized guanine nucleotide exchange fa作者: Expurgate 時間: 2025-3-26 05:06
Rab Proteins and the Organization of Organelle Membrane Domainsins consist of a cluster of specific lipids and proteins that provide membranes with a distinct molecular identity. Rab GTPases are one of the main coordinators of membrane domain formation and dynamics. In this chapter, we will give a brief introduction into Rab GTPases and focus on how they create作者: Optimum 時間: 2025-3-26 10:26
Effectors of Rab GTPases: Rab Binding Specificity and Their Role in Coordination of Rab Function and via a similar Rab surface area which shows the largest conformational changes upon nucleotide exchange. This surface is also involved in the interaction with other Rab interacting proteins. In spite of the high structural similarity of the Rab proteins, the Rab binding domains of effector proteins 作者: NAVEN 時間: 2025-3-26 15:32 作者: Humble 時間: 2025-3-26 17:06
Rab GEFs and GAPs: The Enigma Variations polarisation and autophagy. Rabs undergo a cycle of activation involving GTP binding and inactivation involving GTP hydrolysis in response to cellular regulators. Each Rab has a cognate GDP–GTP exchange factor (GEF) promoting release of GDP and subsequent binding of GTP, and a GTPase activating pro作者: 反抗者 時間: 2025-3-26 22:29
Ran in Nucleocytoplasmic Transportubunits. The nucleotide state of Ran provides a means by which the cytoplasmic and nucleoplasmic compartments are recognized as a consequence of RCC1, the Ran guanine nucleotide exchange factor (RanGEF), being located in the nucleus, whereas the Ran GTPase activating protein, RanGAP, is located in t作者: 揮舞 時間: 2025-3-27 04:33 作者: ANA 時間: 2025-3-27 07:29
Arf Proteins and Their Regulators: At the Interface Between Membrane Lipids and the Protein Traffickand hydrolysis. The first function identified for Arf proteins was recruitment of cytosolic coat complexes to membranes to mediate vesicle formation. However, subsequent studies have uncovered additional functions, including roles in plasma membrane signalling pathways, cytoskeleton regulation, lipi作者: Afflict 時間: 2025-3-27 11:59 作者: 不規(guī)則 時間: 2025-3-27 17:14
ARF-Like (ARL) ProteinsFs and each other and are assumed to share basic mechanisms of regulation and a very incompletely documented degree of overlapping regulators. At least four ARLs were already present in the last eukaryotic common ancestor, along with one ARF, and these have been expanded to >20 members in mammals. W作者: FLING 時間: 2025-3-27 19:10 作者: Diverticulitis 時間: 2025-3-28 00:41
Rag GTPasesbility to cell growth. Dysregulation of mTORC1 is implicated in a number of human diseases, including cancer and diabetes. In response to amino acid availability the Rag GTPases are regulated by the Ragulator and GATOR complexes, which are a guanine nucleotide exchange factor (GEF) and GTPase activa作者: GROWL 時間: 2025-3-28 05:15 作者: limber 時間: 2025-3-28 10:16
Ran in Nucleocytoplasmic Transportget compartments, respectively. Generally the nucleocytoplasmic transport of macromolecules is mediated by transport factors of the karyopherin-β family that change their conformation depending on whether RanGTP is bound or not, and this conformational change in turn mediates the affinity of the transport factors for their cargoes.作者: 波動 時間: 2025-3-28 12:05
Book 2014 the focus lies on the Rab, Ran and?Arf subfamily members. As in Volume 1, the book is written by international renowned scientists in the field of small G-proteins. In elaborate reviews, biochemistry, structure, function and G-protein - effector interactions are described. Together with Volume 1 th作者: Irritate 時間: 2025-3-28 15:04 作者: BABY 時間: 2025-3-28 18:52 作者: 沒花的是打擾 時間: 2025-3-29 02:01 作者: 光亮 時間: 2025-3-29 06:39
https://doi.org/10.1007/978-3-319-07761-1G-Protein effector-interactions; GTP binding; GTPase; intracellular transport; nucleo-cytoplasmic transp作者: 不在灌木叢中 時間: 2025-3-29 08:04
Effectors of Rab GTPases: Rab Binding Specificity and Their Role in Coordination of Rab Function andlity of the Rab proteins are crucial for their specificity..Rab:effector interactions exhibit a large diversity in binding affinities. The μM equilibrium dissociation constants (..s) of some complexes are most likely crucial for a fast regulation of Rab-regulated processes as they allow fast access 作者: omnibus 時間: 2025-3-29 12:04
A Rab Effector Called the Exocyst and Related Vesicle Tether Complexesing SNARE complex assembly in preparation for membrane fusion. Here, we will review in depth the first of these tethers, the exocyst complex that is required for the exocytic fusion of vesicles with the plasma membrane, and then discuss various parallels in both structure and function with the relat作者: 冷淡一切 時間: 2025-3-29 19:26
Rab GEFs and GAPs: The Enigma Variationscontrast, almost all known Rab GAPs possess a TBC1 domain. Here I will discuss the mechanisms by which these GEFs and GAPs regulate Rab GTPases, highlighting common themes and points of difference, and briefly outlining the cellular processes they regulate.作者: FOLLY 時間: 2025-3-29 20:14
Arf Proteins and Their Regulators: At the Interface Between Membrane Lipids and the Protein Trafficklators outnumber their Arf substrates by at least 3-to-1, an important aspect of understanding Arf function is elucidating the mechanisms by which a single Arf protein is incorporated into different GEF, GAP, and effector complexes. New insights into these mechanisms have come from recent studies sh作者: 占線 時間: 2025-3-30 03:06
