作者: climax 時(shí)間: 2025-3-21 21:55 作者: 熱心 時(shí)間: 2025-3-22 00:58 作者: filial 時(shí)間: 2025-3-22 07:55
Adeno-Associated Virus Gene Therapy and Its Application to the Prevention and Personalised Treatmenis applied to rare diseases, the first section of this chapter aims to illustrate how gene therapy aligns to the principles of PPPM whereas the second part of the chapter intends to provide an in depth review of the developments in the AAV field that underpin the use of these viruses as gene therapy delivery systems.作者: 似少年 時(shí)間: 2025-3-22 12:23
National Plans on Rare Diseases,specific features and approaches. It critically assesses the national achievements in this field, drawing conclusions to further strengthen the process of planning, implementing and evaluating RD national policies..A national plan for RD can be defined as an official strategic public health document作者: laxative 時(shí)間: 2025-3-22 14:25
,Biobanking for Rare Diseases – Impact on Personalised Medicine,ee the rights of stakeholders. Due to their medical and scientific expertise, they offer collections of human biological resources that meet with research project requirements. Because of their secure storage capacities, biobanks are front-line actors in collection management by enabling their devel作者: detach 時(shí)間: 2025-3-22 18:13 作者: invade 時(shí)間: 2025-3-23 01:00
Personalized Medicine for Hereditary Deafness,s. While the clinical phenotype, deafness, is shared and similar across different individuals, the substantial genetic heterogeneity makes the genetic etiology in individual cases rare. Identification of genetic causes has been central to a growing body of knowledge related to diagnostic tools, gene作者: 慢跑鞋 時(shí)間: 2025-3-23 05:20 作者: 報(bào)復(fù) 時(shí)間: 2025-3-23 08:41 作者: cauda-equina 時(shí)間: 2025-3-23 12:09
Enzyme Replacement Therapy in Lysosomal Storage Diseases,ysosomes before expanding to most of body tissues and organs. Impaired enzyme activity, molecular trafficking and transport of these proteins resulting from genetic mutations constitute the main pathogenic mechanisms. Clinical manifestations include storage signs and symptoms such as enlarged liver 作者: LOPE 時(shí)間: 2025-3-23 17:10
Rare Cancers, biology have resulted in novel ways to classify cancers based upon genetic alterations and not just anatomical location, and this revised classification is at the heart of any move toward more personalized healthcare. It is now increasingly accepted that cancer should be thought of as many hundreds作者: alabaster 時(shí)間: 2025-3-23 18:22
Adeno-Associated Virus Gene Therapy and Its Application to the Prevention and Personalised Treatmenene therapy and has brought this type of therapy even closer to clinical practice. There is little closer to the personalisation of medicine than the ability to repair or restore the function of a person’s own faulty genes, the core principle of gene therapy. It is therefore reasonable to argue that作者: 異教徒 時(shí)間: 2025-3-24 00:32
Induced Pluripotency for the Study of Disease Mechanisms and Cell Therapy, by direct cell replacement and also by paracrine effects. Advantage of iPS cells is also their unlimited availability. In this chapter we characterize the pluripotent state of cells starting from embryonic stem (ES) cells and comparing them with iPS cells. We also describe different ways of using i作者: harbinger 時(shí)間: 2025-3-24 05:23
2211-3495 rial for paradigm change towards predictive, preventive and This book focuses on predictive, preventative and personalized medicine (PPPM) and how it is related to the healthcare of rare diseases. Readers will discover how advanced rare diseases healthcare provides an excellent “proof-of-principles”作者: 貪婪性 時(shí)間: 2025-3-24 07:04
Emerging Technologies for Gene Identification in Rare Diseases,hnologies based on Next Generation Sequencing (NGS) greatly facilitate the discovery of disease-causing genes, especially when coupled with efficient data-analysis strategy. Additionally, NGS is slowly entering the clinical arena as a diagnostic tool for rare diseases, drastically reducing the time required to arrive at a correct diagnosis.作者: 水汽 時(shí)間: 2025-3-24 11:25
Book 2015discover how advanced rare diseases healthcare provides an excellent “proof-of-principles” for the personalisation of healthcare systems on a global scale. Chapters look at national plans for rare disease, at biobanking, gene identification, rare cancers, virus gene therapy , induced pluripotency fo作者: MOCK 時(shí)間: 2025-3-24 18:21 作者: aesthetic 時(shí)間: 2025-3-24 20:54 作者: 冰河期 時(shí)間: 2025-3-25 01:12 作者: 搖晃 時(shí)間: 2025-3-25 07:00 作者: Intersect 時(shí)間: 2025-3-25 07:38 作者: 懸崖 時(shí)間: 2025-3-25 12:35 作者: 占卜者 時(shí)間: 2025-3-25 17:49 作者: cliche 時(shí)間: 2025-3-25 20:59
Complexity of Genotype-Phenotype Correlations in Mendelian Disorders: Lessons from Gaucher Disease,d the complexity in interpreting genetic data in multigene disorders. Factors including genetic modifiers, gene-gene interaction, reduced penetrance, imprinting, processed and non-processed pseudogenes, regulatory polymorphisms, epigenetics and the abundant number of private mutations, provide chall作者: 接合 時(shí)間: 2025-3-26 00:08 作者: LAST 時(shí)間: 2025-3-26 05:33
Induced Pluripotency for the Study of Disease Mechanisms and Cell Therapy,s with genetic or other disorders and use of them as a “human cell model of human disease” to understand the mechanisms of the disease and to possibly find new chemicals to correct the defective pathways. This approach has already led to discoveries of new routes to medical treatments and potentiall作者: 控制 時(shí)間: 2025-3-26 11:15 作者: antiandrogen 時(shí)間: 2025-3-26 15:22 作者: Extricate 時(shí)間: 2025-3-26 18:48 作者: 修飾 時(shí)間: 2025-3-26 23:22 作者: 疾馳 時(shí)間: 2025-3-27 04:03 作者: DECRY 時(shí)間: 2025-3-27 05:48
Maria Judit Molnar,Klara PentelenyiAs an interdisciplinary tool, it will provide practical, authoritative information both for those involved in crime and security studies, as well as those from related disciplines who increasingly need to consider security as part of their work, such as police studies, counterterrorism, urban planni作者: 破譯 時(shí)間: 2025-3-27 13:12 作者: 螢火蟲(chóng) 時(shí)間: 2025-3-27 16:05 作者: Vital-Signs 時(shí)間: 2025-3-27 21:03
As an interdisciplinary tool, it will provide practical, authoritative information both for those involved in crime and security studies, as well as those from related disciplines who increasingly need to consider security as part of their work, such as police studies, counterterrorism, urban planni作者: Harass 時(shí)間: 2025-3-27 22:36
978-94-024-0802-7Springer Science+Business Media Dordrecht 2015作者: GUILE 時(shí)間: 2025-3-28 03:20
Rare Diseases978-94-017-9214-1Series ISSN 2211-3495 Series E-ISSN 2211-3509 作者: 打擊 時(shí)間: 2025-3-28 07:54
Advances in Predictive, Preventive and Personalised Medicinehttp://image.papertrans.cn/r/image/821232.jpg作者: 表被動(dòng) 時(shí)間: 2025-3-28 13:14
https://doi.org/10.1007/978-94-017-9214-1Invivo disease models; Personalized medicine; Personalized therapies; Personel genome based diagnosis; R作者: 物質(zhì) 時(shí)間: 2025-3-28 18:16 作者: VAN 時(shí)間: 2025-3-28 18:58
ompeting texts focus mainly on one or the other end of the t.The main purpose of the volume is to provide a synthesis of (1) the physical and chemical bases of dating methods, and (2) the applications of dating methods to the geological sciences, biology, and archaeology. This volume will serve as t作者: dictator 時(shí)間: 2025-3-28 23:51 作者: Musculoskeletal 時(shí)間: 2025-3-29 07:01 作者: 狂亂 時(shí)間: 2025-3-29 08:46 作者: LASH 時(shí)間: 2025-3-29 15:00 作者: Feature 時(shí)間: 2025-3-29 18:45
Maria Judit Molnar,Klara Pentelenyiample: cybercrime, terrorism, shoplifting and fraud), to applications on the job, to coordination between public and private sectors in handling security and emergency situations nationally and internationally. Special attention is given to security concepts, methods, functions, theories, organizati
