標(biāo)題: Titlebook: Randomised Controlled Clinical Trials; Christopher J. Bulpitt Book 1996Latest edition Springer Science+Business Media New York 1996 drugs. [打印本頁] 作者: 游牧 時間: 2025-3-21 18:27
書目名稱Randomised Controlled Clinical Trials影響因子(影響力)
作者: 準(zhǔn)則 時間: 2025-3-21 20:31 作者: LAPSE 時間: 2025-3-22 00:46
Recruitment of Subjects,The recruitment of subjects must be considered very carefully to ensure that sufficient persons with the characteristics required by the investigators are enrolled within an appropriate period of time. The number of subjects is of great importance and was discussed in chapter 6.作者: Reservation 時間: 2025-3-22 05:57 作者: 愚笨 時間: 2025-3-22 11:27 作者: obnoxious 時間: 2025-3-22 15:44
,The Conduct of the Trial — Good Clinical Practice,are foreseen and taken into account of prior to the start of the trial and those that are unexpected. Murphy’s law states, “..” This law has been attributed to captain E Murphy, a development engineer, who applied it first to an individual technician saying, “.” [215].作者: 某人 時間: 2025-3-22 18:09 作者: BAIL 時間: 2025-3-23 00:15
Early Trials on New Drugs, three phases of early trials: trials to determine safety and early clinical pharmacology (phase I); trials to determine clinical efficacy and further clinical pharmacology (phase II); and trials for the early clinical development of the drug (phase III). A drug regulatory authority may be involved in these early trials.作者: Brittle 時間: 2025-3-23 03:56 作者: 不能和解 時間: 2025-3-23 08:19
asurement of the benefit:risk comparison; determination ofcost- effectiveness and cost utility; stopping rules for trials;meta-analysis and subgroup analysis are all new sections. Thereferences are expanded from 305 to 512 and include the recentadvances in trial design, such as the .n.-of-1 trials a作者: 嬰兒 時間: 2025-3-23 10:26 作者: SSRIS 時間: 2025-3-23 15:42 作者: ANTI 時間: 2025-3-23 18:56
Writing The Protocol, and lastly supplying a permanent record of what was intended in the trial. The same document may serve all these functions, and in addition a section on finances may be included when the document is used as a grant application.作者: 軍械庫 時間: 2025-3-24 01:26 作者: Concerto 時間: 2025-3-24 05:15 作者: 有限 時間: 2025-3-24 08:00
Analysis of the Results, Subgroup and Meta-Analysis,nd scope of this book to describe in detail the statistical methods required to analyse the results of randomised controlled trials. The reader is referred to standard texts such as the books by Armitage and Berry [290], Everitt [291] and Bailar and Mosteller [292].作者: macabre 時間: 2025-3-24 13:10 作者: 聯(lián)想記憶 時間: 2025-3-24 17:08
nalysis are all new sections. Thereferences are expanded from 305 to 512 and include the recentadvances in trial design, such as the .n.-of-1 trials andmegatrials, and up-to-date examples to illustrate the points made inthe 20 chapters.978-1-4613-7915-7978-1-4615-6347-1作者: 腫塊 時間: 2025-3-24 21:01 作者: Muscularis 時間: 2025-3-25 00:21
The Objectives of a Randomised Controlled Trial,an investigator may be interested in a trial of a new antihypertensive drug in elderly patients. The major objective could be either to demonstrate the efficacy of the drug in lowering blood pressure or in preventing cardiovascular deaths. The first objective could be answered in a few patients stud作者: 奇怪 時間: 2025-3-25 03:56 作者: Morbid 時間: 2025-3-25 09:02
How Many Subjects are Required For a Trial?,defined for the trial; the level of significance that must be achieved if the objective is reached; the confidence with which a result will be reported if the objective is not reached; and the variability of the end-point measurements.作者: FLAIL 時間: 2025-3-25 14:07 作者: Inflated 時間: 2025-3-25 16:52 作者: 偏狂癥 時間: 2025-3-25 22:54
,The Conduct of the Trial — Good Clinical Practice,are foreseen and taken into account of prior to the start of the trial and those that are unexpected. Murphy’s law states, “..” This law has been attributed to captain E Murphy, a development engineer, who applied it first to an individual technician saying, “.” [215].作者: Curmudgeon 時間: 2025-3-26 02:48 作者: 牲畜欄 時間: 2025-3-26 07:15 作者: Free-Radical 時間: 2025-3-26 09:54 作者: deceive 時間: 2025-3-26 16:21 作者: optic-nerve 時間: 2025-3-26 18:49
The Detection of Adverse Drug Reactions, lack of efficacy being classified as an ADR [408]. During the course of a randomised trial it may not be recognised that an occurrence is indeed an ADR. Only the final analysis may reveal that the adverse event is due to a drug. This has led to the collection of Adverse Events (AEs) during a trial.作者: 折磨 時間: 2025-3-26 23:04
Measurement of the Benefit : Risk Comparison, Cost-Effectiveness and Cost-Utility.,the same units as benefits and comprise increases in mortality and morbidity and a deterioration in QOL. Both benefit and risk should be expressed numerically as incidence, for example a 1% decrease in mortality from coronary heart disease/year to be compared with 0.01%/year increase in deaths from 作者: Subjugate 時間: 2025-3-27 04:02 作者: Congestion 時間: 2025-3-27 06:06 作者: mastoid-bone 時間: 2025-3-27 12:29
Different Trial Designs,concurrently (cross-over trial to detect an interaction). The remaining design variations do not involve a fixed number of persons being entered. The standard trial, cross-over trial, trial to detect an interaction between treatments, and cross-over trial to detect an interaction are illustrated in figure 5-1 for four treatments A, B, C, and D.作者: 聚集 時間: 2025-3-27 16:01
Information to be Collected During a Trial, defaulters and the attempts made to contact them. This chapter also considers the quantity of data to be collected, the design of documents, the questions to be asked, and the various stages of data preparation.作者: perpetual 時間: 2025-3-27 17:51 作者: 有雜色 時間: 2025-3-27 22:23 作者: calumniate 時間: 2025-3-28 02:11
The Evaluation of Subjective Well-Being and Measurement of Quality of Life,l. Only a few of the subjects may be expected to get the disease and in only a proportion of these may the preventive medicine be effective; yet adverse effects may affect all the subjects. In such a situation small risks may outweigh small gains and it is important to measure subjective well-being 作者: 泄露 時間: 2025-3-28 08:42 作者: MIR 時間: 2025-3-28 13:46 作者: 抗生素 時間: 2025-3-28 16:57
e of data. GIS is widely utilized by national and local authorities, private enterprises, non-governmental organizations (NGOs), and experts due to its ability to integrate spatial data with descriptive attributes. Moreover, GIS plays a significant role in the context of smart cities, representing t作者: 使激動 時間: 2025-3-28 21:37 作者: 確定的事 時間: 2025-3-28 22:55
Nils Rennebachvisual analytics tools and techniques to synthesize information and detect the data anomalies (possible outbreaks) from massive, dynamic, and often ambiguous surveillance data. Represented visually, the assessments of public health status are better understood and also more effectively communicated 作者: 鴕鳥 時間: 2025-3-29 04:16 作者: 貴族 時間: 2025-3-29 11:16 作者: kyphoplasty 時間: 2025-3-29 15:07
Populationorld total. The population has increased nearly sevenfold since the beginning of the twentieth century, when it was about 45 million, nearly fivefold since 1920, when it was about 61 million, and by 58 percent over the last twenty years.作者: Confirm 時間: 2025-3-29 16:11
Liver Disease and Anticancer Drug Treatment,iven to patients at doses producing moderate to severe toxicity. Significant patient toxicity is closely associated with the use of all the effective anticancer drugs (1). There is good evidence that higher doses of anticancer drugs offer a greater likelihood of therapeutic response and in order to 作者: 記憶法 時間: 2025-3-29 23:30 作者: 圓柱 時間: 2025-3-30 03:52
Nootropika,Aufmerksamkeit, Urteilsverm?gen und Orientierung verbessern und beeintr?chtigte soziale Alltagsaktivit?ten beheben k?nnen. Die Substanzen sind sehr heterogen, entstammen verschiedensten pharmakologischen Gruppen und haben unterschiedliche Wirkmechanismen. Es wird vermutet, da? die Nootropika noch fu作者: Immunotherapy 時間: 2025-3-30 05:55
Optimal Nash Equilibria for Bandwidth Allocationndwidth she receives among all links in her desired path. Recent market mechanisms for this problem have either focused on only Nash welfare?[.], or ignored strategic behavior?[.]. We propose a nonlinear variant of the classic trading post mechanism, and show that for almost the entire family of CES作者: audiologist 時間: 2025-3-30 11:49
J. Bowers international status it deserves and the organization of a series devoted to it is very timely in view of its actual rapid development. Biologists, physiologists, and biochemists, independently of their basic scientific orientation, will find this new series of major interest.978-3-642-73377-2978-3-642-73375-8Series ISSN 0938-2763 作者: expansive 時間: 2025-3-30 15:39
Attributionstheorienent auch dazu, das eigene Selbstbild gegen Abwertungen zu verteidigen oder zu steigern (sog. Selbstwerterh?hung). Dieses Feld behandelt eine Reihe von Attributionstheorien. Sie erkl?ren das, was Laien als den ?gesunden Menschenverstand“ bezeichnen.作者: Charitable 時間: 2025-3-30 18:37 作者: SSRIS 時間: 2025-3-30 23:53
A Simple Operating System Kernel,al Kofi Annan looked in depth at Bosnia (Loizides and Keskiner, 2004). Joe R. Biden and Leslie H. Gelb (2006) suggested that after ‘a(chǎn) decade [living] in relative peace’ that Bosnia could be used as a model for the partition of Iraq. More often prolonged conflict in Bosnia in the 1990s has been regar作者: 橫條 時間: 2025-3-31 01:02 作者: Erythropoietin 時間: 2025-3-31 06:52
: How Horizontal Gene Transfer Shaped Two Different Pathogenic Lifestyles in a Marine Bacterium strains, and a large virulence plasmid that encodes a type III secretion system has been described in the type strain of this subspecies. Regarding the subspecies ., many isolates harbor a small (pPHDP10) and a large plasmid (pPHDP70) that encode the apoptotic toxin AIP56 and the siderophore piscib作者: Override 時間: 2025-3-31 12:29
2365-7472 resenting novel ‘perceptual portraits’ of the artists and scientists who have augmented the art of illusion. The reader can experience the paradoxes of pictures as well as producing their own by using the stere978-3-319-25229-2Series ISSN 2365-7472 Series E-ISSN 2365-7480 作者: ESPY 時間: 2025-3-31 16:30
Zeit m?glichst sinnvoll zu verwenden. Entscheiden Sie sich nun dafür, um 6:00?Uhr in der Früh aufzustehen, um vor der ersten Vorlesung noch eine Runde joggen zu gehen, so haben Sie eine Entscheidung zwischen Alternativen gew?hlt. . noch eine Stunde l?nger schlafen . stattdessen eine Runde laufen. F作者: 媒介 時間: 2025-3-31 20:58 作者: 放逐 時間: 2025-4-1 00:03
Conference proceedings 2008etherlands, during June 14-17, 2008, in collaboration with the NLGD Festival of Games. The 24 revised papers presented during the workshop cover topics on crowd simulation; virtual humans; motion synthesis; interfaces; navigation and steering; and facial and behavioral animation.
