標題: Titlebook: RNA Towards Medicine; Volker Erdmann,Jan Barciszewski,Jürgen Brosius Book 2006 Springer-Verlag Berlin Heidelberg 2006 DNA.RNAi.Termination [打印本頁] 作者: 選民 時間: 2025-3-21 17:17
書目名稱RNA Towards Medicine影響因子(影響力)
書目名稱RNA Towards Medicine影響因子(影響力)學(xué)科排名
書目名稱RNA Towards Medicine網(wǎng)絡(luò)公開度
書目名稱RNA Towards Medicine網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱RNA Towards Medicine被引頻次
書目名稱RNA Towards Medicine被引頻次學(xué)科排名
書目名稱RNA Towards Medicine年度引用
書目名稱RNA Towards Medicine年度引用學(xué)科排名
書目名稱RNA Towards Medicine讀者反饋
書目名稱RNA Towards Medicine讀者反饋學(xué)科排名
作者: 分貝 時間: 2025-3-21 21:29 作者: Arthritis 時間: 2025-3-22 02:08
Regulatory RNAs in Mammals,ell-known classes of RNAs that take part in the transmission of genetic information from DNA to proteins, a new highly heterogeneous group of RNA molecules has emerged. The regulatory nonprotein-coding RNAs (npcRNAs) have been shown to be involved in modulation of gene expression on both the transcr作者: 柳樹；枯黃 時間: 2025-3-22 07:55
Aminoglycoside Interactions with RNAs and Nucleases,des interact and interfere with the function of several noncoding RNAs, among which ribosomal RNAs (rRNAs) are the best studied. Aminoglycosides are also known to interact with proteins such as ribonucleases. Here we review our current understanding of the interaction between aminoglycosides and RNA作者: mucous-membrane 時間: 2025-3-22 08:58 作者: 壓迫 時間: 2025-3-22 15:26
Antiviral Applications of RNAi,get gene. This down-regulation has been thought to predominantly function at the level of the messenger (m)RNA, post-transcriptional gene silencing (PTGS). Recently, the discovery that siRNAs can function to suppress a gene’s expression at the level of transcription, i.e., transcriptional gene silen作者: 客觀 時間: 2025-3-22 18:39
RNA Interference: Its Use as Antiviral Therapy,against viruses and transposons. RNAi was first observed in plants in the form of a mysterious immune response to viral pathogens. But RNAi is more than just a response to exogenous genetic material. Small RNAs termed microRNA (miRNA) regulate cellular gene expression programs to control diverse ste作者: ALE 時間: 2025-3-22 22:45
Gene Silencing of Virus Replication by RNA Interference,RNAs are widely used for assessing gene function in cultured mammalian cells or early developing vertebrate embryos. They are also promising reagents for developing gene-specific therapeutics. The specific inhibition of viral replication is particularly well suited to RNAi, as several stages of the 作者: expdient 時間: 2025-3-23 04:59
Progress in the Development of Nucleic Acid Therapeutics,ly less toxic than conventional therapies due its specificity. Over the years, many strategies have been proposed for silencing gene expression in a gene-specific manner. Three major approaches are antisense oligonucleotides (AS-ONs), ribozymes/DNAzymes, and RNA interference (RNAi). In this brief re作者: 小木槌 時間: 2025-3-23 09:33
Screening and Determination of Gene Function Using Randomized Ribozyme and siRNA Libraries,vided abundant sequence information, but functions of long stretches of these genomes remain to be determined. RNA-based technologies hold promise as tools that allow us to identify the specific functions of portions of these genomes. In particular, catalytic RNAs, known also as ribozymes, can be en作者: 談判 時間: 2025-3-23 12:06 作者: 任意 時間: 2025-3-23 17:34 作者: falsehood 時間: 2025-3-23 20:49
Oligonucleotide-Based Antiviral Strategies,tion measures and medical care in poorer countries, greatly facilitates the emergence and dissemination of new virus strains. The appearance of avian influenza viruses that can infect humans, the spread of the severe acute respiratory syndrome (SARS) virus, and the unprecedented raging of human immu作者: 減去 時間: 2025-3-24 01:40 作者: phytochemicals 時間: 2025-3-24 06:22
RNA Aptamers: From Basic Science Towards Therapy,gands (aptamers) from combinatorial oligonucleotide libraries against a target molecule. In the beginning of the technique’s use, RNA molecules were identified that bind to proteins that naturally interact with nucleic acids or to small organic molecules. In the following years, the use of the SELEX作者: 責(zé)問 時間: 2025-3-24 06:45
RNA Aptamers Directed Against Oligosaccharides,rates, abundant constituents of glycoproteins and glycolipids, are not common in cells. Biomedical applications of nucleic acids targeted against oligosaccharides, which are involved in the function of receptors, immune answer, host interaction with invading infectious agents, and cancer metastasis,作者: Ledger 時間: 2025-3-24 11:52 作者: agitate 時間: 2025-3-24 18:52
Application of Aptamers in Therapeutics and for Small-Molecule Detection,ent enzymatic methods. molecule classes. The main focus of this chapter is small molecules as targets. Aptamers are applied complementarily to antibody technologies and can substitute antibodies or small molecules wherever their different properties, such as biochemical nature or highly discriminati作者: Anthem 時間: 2025-3-24 21:12 作者: 社團 時間: 2025-3-24 23:33
Ribozymes and siRNAs: From Structure to Preclinical Applications,ent mRNA cleavage. To attain stability, ribozymes and siRNAs must also overcome several other problems, including accessibility to target messenger RNAs (mRNAs), efficient delivery to target cells and unwanted non-specific effects.作者: micturition 時間: 2025-3-25 03:46 作者: excrete 時間: 2025-3-25 11:01 作者: tinnitus 時間: 2025-3-25 13:22
Regulatory RNAs in Mammals,fluencing mRNA stability, processing, and translation. npcRNAs are key factors in genetic imprinting, dosage compensation of X-chromosome-linked genes, and many processes of differentiation and development.作者: 注入 時間: 2025-3-25 19:51
Aminoglycoside Interactions with RNAs and Nucleases,nt bacterial strains. Taken together, the general knowledge about aminoglycoside and RNA interaction is of utmost importance in the process of identifying/developing the next generation or new classes of antibiotics. In this perspective, previously unrecognized as well as known noncoding RNAs, apart from rRNA, are promising targets to explore.作者: 治愈 時間: 2025-3-25 21:27 作者: 果仁 時間: 2025-3-26 00:32
Gene-Expressed RNA as a Therapeutic: Issues to Consider, Using Ribozymes and Small Hairpin RNA as S address the relevant scientific and some of the commercial issues in the use of RNA as a therapeutic. Specifically, the chapter discusses delivery, expression, potency, toxicity and commercial development using, as examples, hammerhead ribozymes and small hairpin RNA.作者: 旅行路線 時間: 2025-3-26 06:15
RNA Aptamers Directed Against Oligosaccharides,s of biochemical recognition processes in which carbohydrates are involved. Several RNA and DNA aptamers directed against carbohydrates have already been isolated and characterized. The results are summarized in this article, and an attempt is made to draw initial conclusions concerning the perspectives of the outlined approach.作者: 心胸開闊 時間: 2025-3-26 12:22 作者: Genetics 時間: 2025-3-26 13:29
Progress in the Development of Nucleic Acid Therapeutics,view, we will discuss the successes and shortcomings of these three gene-silencing methods, and the approaches being taken to improve the effectiveness of antisense molecules. We will also provide an overview of some of the clinical applications of antisense therapy.作者: 解開 時間: 2025-3-26 20:02 作者: Enteropathic 時間: 2025-3-27 00:55 作者: Affection 時間: 2025-3-27 04:57
0171-2004 RNAs, amplification/selection (SELEX) generated aptamers as well as ribozymes are at the threshold of impacting medicine..978-3-642-06603-0978-3-540-27262-5Series ISSN 0171-2004 Series E-ISSN 1865-0325 作者: 高原 時間: 2025-3-27 07:35
High-Throughput RNA Interference in Functional Genomics,ional genomics studies using RNAi, several high-throughput approaches have been developed based on microarray or microwell assays. The recent establishment of large libraries of RNAi reagents combined with a variety of detection assays has further improved the performance of functional genome-wide screens in mammalian cells.作者: gnarled 時間: 2025-3-27 11:29
Gene Silencing of Virus Replication by RNA Interference,for developing gene-specific therapeutics. The specific inhibition of viral replication is particularly well suited to RNAi, as several stages of the viral life cycle and many viral and cellular genes can be targeted. The future success of this approach will depend on the recent advances in siRNA-based clinical trials.作者: 兵團 時間: 2025-3-27 16:30
Book 2006arious promising avenues where RNA and nucleic acid derivatives including antisense RNAs, such as siRNA, miRNAs, amplification/selection (SELEX) generated aptamers as well as ribozymes are at the threshold of impacting medicine..作者: Allege 時間: 2025-3-27 20:09 作者: RENIN 時間: 2025-3-28 01:48
quantitative predictions of experimentally measured behavior, so that comparisons between theory and experiment can be readily made. We first outline essential features of the dramatic phenomena, and then describe basic features of a quantitative theory based on transient aqueous pores. Throughout w作者: 空中 時間: 2025-3-28 04:06
A. Richgation of regulatory regions associated with a gene, various animal systems and tissue-cultured cells are widely employed, each having unique advan tages and drawbacks. We find that electroporation of chicken embryos is most advantageous for systematic survey of development-associated regulatory reg作者: blackout 時間: 2025-3-28 06:42
T. Geissmann,M. Possedko,E. Huntzinger,P. Fechter,C. Ehresmann,P. Rombygation of regulatory regions associated with a gene, various animal systems and tissue-cultured cells are widely employed, each having unique advan tages and drawbacks. We find that electroporation of chicken embryos is most advantageous for systematic survey of development-associated regulatory reg作者: 換話題 時間: 2025-3-28 11:16
M. Szymański,J. Barciszewskidhemovic I, et al. Biomed Eng Online 14 Suppl 3: S5, 2015). The treatment of tumors of the bladder and urethra is mainly clinical with stabilization of the disease by chemotherapy and a median survival >1-year has been noted with this treatment. A surgical approach is not ever feasible as the involv作者: 要求比…更好 時間: 2025-3-28 16:35
L.A. Kirsebom,A. Virtanen,N.E. Mikkelsen increase the power of DNA immunization, with in vivo electroporation emerging as one of the most attractive approaches. This chapter will provide an overview of?our promising veterinary studies using adjuvant DNA vaccination through in vivo electroporation, targeting the chondroitin sulfate proteog作者: etidronate 時間: 2025-3-28 21:03
M. Janitz,D. Vanhecke,H. Lehrach new electrodes and the implementation of pre-treatment planning advances the acquired experience of current ECT knowledge to treatment of deep-seated and intraluminal localized tumors. The validation of new electrodes in animal model is needed to transfer their use in clinical practice.作者: Rankle 時間: 2025-3-28 23:29 作者: nautical 時間: 2025-3-29 04:27 作者: Lumbar-Spine 時間: 2025-3-29 09:24 作者: glacial 時間: 2025-3-29 15:27
A. Kalota,V.R. Dondeti,A.M. Gewirtzlved ampullary organs and the newly evolved tuberous electroreceptors in teleosts is uncertain. It has been claimed that ampullary organs in catfishes develop from lateral line placodes, whereas ampullary and tuberous organs in gymnotids are claimed to develop from general ectoderm. Clearly, experim作者: Mammal 時間: 2025-3-29 17:31
S. Matsumoto,H. Akashi,K. Tairang of waveform (pulse duration) of their EODs. Pulse duration is sampled by a type of time-coding electroreceptors (knollenorgan) that are specialized for communication and is decoded in the midbrain..Understanding of the tuberous electrosensory system of electric fishes has been greatly advanced as作者: intertwine 時間: 2025-3-29 20:58
M. Sioudlved ampullary organs and the newly evolved tuberous electroreceptors in teleosts is uncertain. It has been claimed that ampullary organs in catfishes develop from lateral line placodes, whereas ampullary and tuberous organs in gymnotids are claimed to develop from general ectoderm. Clearly, experim作者: Accrue 時間: 2025-3-30 01:01 作者: CUB 時間: 2025-3-30 07:17 作者: Airtight 時間: 2025-3-30 09:21 作者: 易于出錯 時間: 2025-3-30 16:17 作者: 注意力集中 時間: 2025-3-30 19:46
M. Sprinzl,M. Milovnikova,C.S. Voertlerng of waveform (pulse duration) of their EODs. Pulse duration is sampled by a type of time-coding electroreceptors (knollenorgan) that are specialized for communication and is decoded in the midbrain..Understanding of the tuberous electrosensory system of electric fishes has been greatly advanced as作者: Anthropoid 時間: 2025-3-30 23:02 作者: gait-cycle 時間: 2025-3-31 04:51 作者: Arb853 時間: 2025-3-31 08:51
H.U. G?ringer,M. Homann,M. Zacharias,A. Adlerng of waveform (pulse duration) of their EODs. Pulse duration is sampled by a type of time-coding electroreceptors (knollenorgan) that are specialized for communication and is decoded in the midbrain..Understanding of the tuberous electrosensory system of electric fishes has been greatly advanced as作者: 偏離 時間: 2025-3-31 11:46
Antiviral Applications of RNAi,since siRNAs are a small nucleic acid reagent, they are unlikely to elicit an immune response, making them a theoretically good future therapeutic. This review will focus on the development, delivery, and potential therapeutic use of antiviral siRNAs in treating viral infections as well as emerging 作者: hardheaded 時間: 2025-3-31 13:39 作者: 鴕鳥 時間: 2025-3-31 18:05 作者: JIBE 時間: 2025-3-31 23:39 作者: 宏偉 時間: 2025-4-1 02:13
