標(biāo)題: Titlebook: RNA Interference and Cancer Therapy; Methods and Protocol Lekha Dinesh Kumar Book 2019 Springer Science+Business Media, LLC, part of Spring [打印本頁(yè)] 作者: CILIA 時(shí)間: 2025-3-21 18:34
書目名稱RNA Interference and Cancer Therapy影響因子(影響力)
書目名稱RNA Interference and Cancer Therapy影響因子(影響力)學(xué)科排名
書目名稱RNA Interference and Cancer Therapy網(wǎng)絡(luò)公開度
書目名稱RNA Interference and Cancer Therapy網(wǎng)絡(luò)公開度學(xué)科排名
書目名稱RNA Interference and Cancer Therapy被引頻次
書目名稱RNA Interference and Cancer Therapy被引頻次學(xué)科排名
書目名稱RNA Interference and Cancer Therapy年度引用
書目名稱RNA Interference and Cancer Therapy年度引用學(xué)科排名
書目名稱RNA Interference and Cancer Therapy讀者反饋
書目名稱RNA Interference and Cancer Therapy讀者反饋學(xué)科排名
作者: Antioxidant 時(shí)間: 2025-3-21 21:42
siRNA-Based Drug Targeting Human Bcl-xL Against Cancers, to functionally deliver tumor-specific siRNA molecules in nude mice. Here, we introduce an orthotopic tumor inoculation model in nude mice: the resulting orthotopic tumors more closely replicate the clinical conditions in humans—including the metastasis mode—than ectopic subcutaneously inoculated tumors.作者: deactivate 時(shí)間: 2025-3-22 04:23
,Design Strategy to Access siRNA-Encapsulating DNA “Nanosuitcases” That Can Conditionally Release Thstrategies. We present an overview of the design strategy used to access these DNA nanostructures, followed by the steps involved in DNA sequence generation, assembly, and validation of this construct.作者: 褪色 時(shí)間: 2025-3-22 06:13 作者: apiary 時(shí)間: 2025-3-22 12:15
,Preparation of a?Carrier to Achieve In Vivo Delivery of siRNA: The Example of Chitosan-Coated Poly(e nanoparticles with the siRNA can be achieved by performing an association yield above 90% using a mass ratio of 1 mg siRNA/50 mg of nanoparticles (20?μg siRNA/mg nanoparticles, 1?nmol siRNA (. 14?kDa)/mg nanoparticles).作者: gerontocracy 時(shí)間: 2025-3-22 14:52 作者: dendrites 時(shí)間: 2025-3-22 17:51 作者: angiography 時(shí)間: 2025-3-23 00:50
Combinatorial siRNA Polyplexes for Receptor Targeting,de a brief background on the formulation design and detailed protocols to evaluate polyplex formation, gene silencing efficiency, and receptor-directed cell killing in cancer cells using targeted combinatorial siRNA polyplexes.作者: Pigeon 時(shí)間: 2025-3-23 02:27
Systemic Modulation of Lymphocyte Subsets Using siRNAs Delivered via Targeted Lipid Nanoparticles,nduce therapeutic gene silencing. This approach utilizes antibodies that decorate lipid nanoparticle surfaces to home into lymphocyte subsets. This approach opens new avenues for discovery of new drug targets and potentially for therapeutics.作者: Charade 時(shí)間: 2025-3-23 07:00
Silencing PRDM14 via Oligonucleotide Therapeutics Suppresses Tumorigenicity and Metastasis of Breasuced the size of tumors and lung metastases in nude mice. In this chapter, we introduce the concept and methods to develop and apply systematically injected small interfering RNA therapy for breast cancer models in vivo.作者: burnish 時(shí)間: 2025-3-23 10:09
siRNA Library Screening to Identify Complementary Therapeutic Pairs in Triple-Negative Breast Canceon of the plasticity of such networks is stimulating the development of combinational therapy to overcome the limitations of one-dimensional therapies. Synergistic pairs of siRNAs or siRNA and drug combinations are the new frontiers in identifying effective therapeutic combinations. To elucidate eff作者: deviate 時(shí)間: 2025-3-23 14:43 作者: 只有 時(shí)間: 2025-3-23 18:43 作者: insightful 時(shí)間: 2025-3-24 00:59
Relative Quantification of siRNA Strand Loading into Ago2 for Design of Highly Active siRNAs,ay proteins, including Argonaute 2 (Ago2). Based on these interactions, one strand of the siRNA is loaded into Ago2 forming the active RNA-induced silencing complex (RISC). Optimal siRNAs maximize RISC activity against the intended target and minimize off-target silencing. To achieve the desired act作者: 植物學(xué) 時(shí)間: 2025-3-24 05:03
VEGFA Gene Silencing in CXCR4-Expressing Cells via siRNA Delivery by Means of Targeted Peptide Carrers. The efficacious delivery of therapeutic siRNAs into the cells is a crucial step in RNA interference (RNAi) application, but it remains challenging. Non-viral vectors can provide specific cellular uptake, stable siRNA complex formation, and intracellular siRNA release. Recently, we evaluated mod作者: CRAMP 時(shí)間: 2025-3-24 08:31 作者: fallible 時(shí)間: 2025-3-24 12:21
Combinatorial siRNA Polyplexes for Receptor Targeting,parkled intense investigations. To develop tumor-specific carriers for cytosolic and systemic siRNA delivery, our laboratory has recently generated folate-conjugated targeted combinatorial siRNA polyplexes based on sequence-defined oligomer platform compatible with solid-phase-supported synthesis. T作者: irradicable 時(shí)間: 2025-3-24 15:08 作者: flavonoids 時(shí)間: 2025-3-24 20:59 作者: Largess 時(shí)間: 2025-3-24 23:48 作者: Vo2-Max 時(shí)間: 2025-3-25 06:53
Systemic Modulation of Lymphocyte Subsets Using siRNAs Delivered via Targeted Lipid Nanoparticles,c modality for hematological malignancies and autoimmune disorders. However, lymphocytes are among the most difficult cells to transfect with RNAi, as they are resistant to conventional transfection reagents and are dispersed throughout the body, making it a challenge to successfully deliver these p作者: Blood-Clot 時(shí)間: 2025-3-25 11:00
Targeting Cancer with Peptide RNAi Nanoplexes, siRNA and gene therapy, all of which require delivery of highly charged nucleic acids from siRNA with a molecular weight of about 1.4?×?10. to plasmids with an approximate molecular weight of 2.0–3.0?×?10.. This chapter describes the delivery of shRNA via plasmid or siRNA with a peptide-based carri作者: 元音 時(shí)間: 2025-3-25 12:43
,Preparation of a?Carrier to Achieve In Vivo Delivery of siRNA: The Example of Chitosan-Coated Poly(es of xenograft tumor models of mice. The nanoparticles are prepared by a method of emulsion polymerization that includes steps of polymerization and purification. The polymerization method is carried out in a single pot in an aqueous medium. siRNAs are coupled with the nanoparticles at the end of t作者: 思想 時(shí)間: 2025-3-25 18:37
Monoclonal Antibody-Conjugated Dendritic Nanostructures for siRNA Delivery, specific and reliable carrier system. Herein we describe a targeted carrier system that can deliver siRNA to cancer cells overexpressing the human epidermal growth factor 2 (HER2) receptor. Trastuzumab-conjugated poly(amido)amine dendrimers can be synthesized using the protocols described here.作者: Epithelium 時(shí)間: 2025-3-25 21:58
Synthesis of Gold Nanoparticles for Gene Silencing,rfering RNAs (siRNAs, 21-base-pair double-stranded RNA) were shown able to elicit RNA interference (RNAi), efforts were directed toward the development of efficient delivery systems to preserve siRNA bioactivity throughout the delivery route, from administration site to the target cell. Starting fro作者: 輕浮思想 時(shí)間: 2025-3-26 00:19
Design of Eco-Friendly Gold Nanoparticles for Cancer Treatment,ing. However, the toxicity of nanoparticles remains a challenge for using them in biological system. The morphology and surface chemistry of GNP can be manipulated by their method of preparation. GNP can be synthesized and functionalized by various methods. This chapter illustrates the synthesis of 作者: 泰然自若 時(shí)間: 2025-3-26 08:18 作者: ATOPY 時(shí)間: 2025-3-26 10:47
Silencing PRDM14 via Oligonucleotide Therapeutics Suppresses Tumorigenicity and Metastasis of Breaslification. In contrast, PRDM14 is not expressed in normal, and differentiated tissues. PRDM14. breast cancer cells are resistant to chemotherapy drugs, are tumorigenic, and metastasize to the lungs. It is commonly assumed that genes that are overexpressed in cancers, such as PRDM14, are effective t作者: interference 時(shí)間: 2025-3-26 12:57
Biodrug Suppresses Breast and Colorectal Cancer in Murine Models,y and greater potency. However, it is hindered due to lack of appropriate targeting technologies. Therefore, there is an imminent need to develop specific and robust delivery systems for successful gene silencing. Nanotechnology-based strategies have been in place to combat the shortcomings associat作者: Infiltrate 時(shí)間: 2025-3-26 19:13
In Vitro Evaluation of Candidate Gene Targets for Cancer Therapy, moving on to animal studies and clinical trials. This chapter describes a relatively simple and straightforward protocol that makes use of small interfering RNA to achieve knockdown of the candidate gene target and to evaluate the resultant effects on four aspects of cancer cell behavior: migration, invasion, proliferation, and adhesion.作者: Basal-Ganglia 時(shí)間: 2025-3-26 21:10
Relative Quantification of siRNA Strand Loading into Ago2 for Design of Highly Active siRNAs,ivity and specificity, selection of the appropriate siRNA strand for loading into Ago2 is essential. Here, we provide a protocol to quantify the relative loading of individual siRNA strands into Ago2, one factor in determining the capacity of a siRNA to achieve silencing activity and target specificity.作者: THROB 時(shí)間: 2025-3-27 02:09
Minicell-Based Targeted Delivery of shRNA to Cancer Cells: An Experimental Protocol,ized by fluorescence microscopy and transmission electron microscopy. In the next step, targeting ligand was conjugated on the minicell surface for the active targeting of cancer cell surface receptors. Eventually, target-specific delivery of minicells was explored in vitro in selected cancer cell line and in vivo in mice bearing tumor xenograft.作者: Asparagus 時(shí)間: 2025-3-27 07:00
Design of Eco-Friendly Gold Nanoparticles for Cancer Treatment,highly biocompatible GNP using a natural gum, i.e., xanthan gum (XG). Moreover, due to the presence of mannose moiety in XG, these XG-stabilized GNP may also act as self-targeted drug carriers for the delivery of chemotherapeutic agents/siRNA/shRNA to mannose receptor overexpressing cancer cells.作者: 釘牢 時(shí)間: 2025-3-27 10:43 作者: Aggressive 時(shí)間: 2025-3-27 16:05
Methods in Molecular Biologyhttp://image.papertrans.cn/r/image/820171.jpg作者: Visual-Acuity 時(shí)間: 2025-3-27 18:44
https://doi.org/10.1007/978-1-4939-9220-1Cancer treatment; Therapeutic tools; RNAi-based strategies; Bio-drugs; Drug development; Targeted deliver作者: 價(jià)值在貶值 時(shí)間: 2025-3-28 01:00 作者: incarcerate 時(shí)間: 2025-3-28 03:06 作者: Pelvic-Floor 時(shí)間: 2025-3-28 09:59 作者: 葡萄糖 時(shí)間: 2025-3-28 14:15 作者: filicide 時(shí)間: 2025-3-28 16:14
l City Authority use to disclose information on its operations? What is the mix of offline- and online channels (blended participation) do local political representatives use to connect with electorates? Is this more for planning or for monitoring purposes. To answer these questions, both quantitati作者: Incumbent 時(shí)間: 2025-3-28 20:36 作者: 死亡率 時(shí)間: 2025-3-28 22:56
Xing Fei Tan,Wei Xuan Teo,George W. Yipses often meets a wide variety of resistance. Hence, this paper investigates what barriers but also chances these communication experts identify from their professional point of view. For this purpose, we have conducted a quantitative study with more than 100 participants, including journalists, pre作者: 否決 時(shí)間: 2025-3-29 04:06 作者: 廢墟 時(shí)間: 2025-3-29 07:37
Phillip A. Angart,Kwasi Adu-Berchie,Rebecca J. Carlson,Daniel B. Vocelle,Christina Chan,S. Patrick Wses often meets a wide variety of resistance. Hence, this paper investigates what barriers but also chances these communication experts identify from their professional point of view. For this purpose, we have conducted a quantitative study with more than 100 participants, including journalists, pre作者: malapropism 時(shí)間: 2025-3-29 12:49
Anna A. Egorova,Marianna A. Maretina,Anton V. Kiselevles for analyzing potential needs for re-design of institutions. Through a re-analysis of two case studies on automation in Swedish public organizations, we illustrate and discuss the institutional design. Hereby, we identify critical points for further analysis of emerging demands for institutional作者: ELUDE 時(shí)間: 2025-3-29 17:25 作者: single 時(shí)間: 2025-3-29 20:19 作者: Blanch 時(shí)間: 2025-3-30 00:13
Daniel F. Costa,Can Sarisozen,Vladimir P. Torchilinogy describing entities involved in the chosen domain has been developed in order to provide a semantic description of terms in lexicons. A modular integration of such resources, represented in RDF/OWL standard format, allowed their effective and flexible access from a legislative drafting applicati作者: 詞匯記憶方法 時(shí)間: 2025-3-30 05:15 作者: 彩色的蠟筆 時(shí)間: 2025-3-30 08:40 作者: myocardium 時(shí)間: 2025-3-30 15:14 作者: 倔強(qiáng)一點(diǎn) 時(shí)間: 2025-3-30 19:31
A. James Mixson,Qixin Leng,Szu-Ting Chou,Martin C. Woodley match offers of different mobility providers (e.g. voluntary drivers, public transportation services, taxis drivers etc.) with citizens’ mobility demands in rural areas. Citizens needing a ride can find, book and pay the best offer for their journeys through the app. They can also rate the mobilit作者: calumniate 時(shí)間: 2025-3-30 21:57
Christine Vauthierfrom the regulations. The method enables to compare different variants of a legal regulation planned to be established. The presented method was practically applied to the process of registration of a civil law partnership in Poland. It was proved within the conducted research that the process redes作者: frivolous 時(shí)間: 2025-3-31 04:48
Hitesh Kulhari,Ashok K. Jangid,David J. Adamshas been concluded that this approach has the fundamental preconditions for a wide diffusion (relative advantage, compatibility with existing values and processes, reasonable complexity, trialability and observability), at least in government organizations having a tradition of bi-directional commun作者: Collision 時(shí)間: 2025-3-31 07:19
Claudia Tortiglione,Jesús M de la Fuentecollaboration. The second approach is building a linked data set by extracting assessment criteria for a specific social issue from public opinions. This paper deals with candidate terms that potentially represent such criteria for a specific public project automatically extracted from clusters of c作者: 斗志 時(shí)間: 2025-3-31 10:37 作者: Minutes 時(shí)間: 2025-3-31 14:21 作者: 無(wú)脊椎 時(shí)間: 2025-3-31 17:31
Hiroaki Taniguchi,Kohzoh Imaiersal welfare state. The analysis focused on citizenship practices in daily activities when technologies mediate participation and interaction among the public, civic and market actors. The conclusions contribute to the conceptualization of citizenship act and agency and elaborates on citizenship as作者: miracle 時(shí)間: 2025-3-31 21:41
Syed Sultan Beevi,Naveen Kumar Tangudu,Vinod Kumar Verma,Lekha Dinesh Kumarvation in the public sector. It provides relevant examples from child protection services to illustrate where and how these different theoretical foundations help researchers to understand phenomena associated with social innovation. In so doing, this paper seeks to clarify the diverse approaches to作者: 杠桿支點(diǎn) 時(shí)間: 2025-4-1 05:16 作者: Feigned 時(shí)間: 2025-4-1 06:28 作者: ordain 時(shí)間: 2025-4-1 13:28
VEGFA Gene Silencing in CXCR4-Expressing Cells via siRNA Delivery by Means of Targeted Peptide CarrFA gene expression in A172 glioblastoma cells and in EA.hy 926 endothelial cells. Also, delivery of anti-VEGFA siRNA/peptide complexes led to significant inhibition of endothelial cell migration. Our results showed that L1 peptide carrier modified with CXCR4 ligand is a promising tool for targeted s作者: Anguish 時(shí)間: 2025-4-1 16:30 作者: Genome 時(shí)間: 2025-4-1 18:48 作者: 不近人情 時(shí)間: 2025-4-1 23:34
64Cu-Labeled Aptamers for Tumor-Targeted Radionuclide Delivery, using positron emission tomography (PET). Closely following this protocol allows many aptamers to be successfully radiolabeled to accurately and quantitatively trace their distribution in vivo for a wide range of medical applications.作者: 貧窮地活 時(shí)間: 2025-4-2 05:20 作者: 雪白 時(shí)間: 2025-4-2 10:07
