標(biāo)題: Titlebook: Quantitative Decisions in Drug Development; Christy Chuang-Stein,Simon Kirby Book 20171st edition Springer International Publishing AG 201 [打印本頁] 作者: 指責(zé) 時(shí)間: 2025-3-21 19:10
書目名稱Quantitative Decisions in Drug Development影響因子(影響力)
書目名稱Quantitative Decisions in Drug Development影響因子(影響力)學(xué)科排名
書目名稱Quantitative Decisions in Drug Development網(wǎng)絡(luò)公開度
書目名稱Quantitative Decisions in Drug Development網(wǎng)絡(luò)公開度學(xué)科排名
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書目名稱Quantitative Decisions in Drug Development被引頻次學(xué)科排名
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書目名稱Quantitative Decisions in Drug Development讀者反饋
書目名稱Quantitative Decisions in Drug Development讀者反饋學(xué)科排名
作者: 尋找 時(shí)間: 2025-3-22 00:15 作者: 關(guān)心 時(shí)間: 2025-3-22 01:32
Characteristics of a Diagnostic Test,nt years, companion diagnostics have been developed to preselect patients for specific treatments based on their own biology. In this chapter, we review the metrics commonly used to characterize the performance of a diagnostic test. We then discuss what it means when a diagnostic test returns a posi作者: Infraction 時(shí)間: 2025-3-22 07:33
The Parallel Between Clinical Trials and Diagnostic Tests,on to diagnose is whether the new drug has a clinically meaningful efficacious effect. This comparison offers us the opportunity to apply properties pertaining to diagnostic tests discussed in Chap. 3 to clinical trials. Building on the results in Chap. 3, we discuss why replication is such a critic作者: AWL 時(shí)間: 2025-3-22 12:25
Incorporating Information from Completed Trials in Future Trial Planning,onsider the Bayesian approach to incorporate existing information into future trial planning. Under the Bayesian approach, prior distributions are used to describe the accumulated knowledge about unknown parameters such as those representing treatment effects. The prior distributions are then used t作者: exigent 時(shí)間: 2025-3-22 13:21 作者: 的是兄弟 時(shí)間: 2025-3-22 20:11
Designing Proof-of-Concept Trials with Desired Characteristics,patients, and if the drug appears to have an effect, whether the size of the effect warrants investment in further development. A number of approaches have been proposed to make a decision for a POC study. In this chapter we review five of them. They are, the traditional hypothesis testing approach,作者: peptic-ulcer 時(shí)間: 2025-3-23 00:25 作者: 疲勞 時(shí)間: 2025-3-23 03:19 作者: objection 時(shí)間: 2025-3-23 05:50 作者: 引起 時(shí)間: 2025-3-23 10:37 作者: Medley 時(shí)間: 2025-3-23 14:47 作者: 清真寺 時(shí)間: 2025-3-23 19:06 作者: condemn 時(shí)間: 2025-3-24 00:00 作者: 作嘔 時(shí)間: 2025-3-24 03:13 作者: wall-stress 時(shí)間: 2025-3-24 10:07
The Parallel Between Clinical Trials and Diagnostic Tests,fference between statistical power and the probability of a positive trial. This last point becomes more important as a new drug moves through the various development stages as will be illustrated in Chap. 9.作者: jeopardize 時(shí)間: 2025-3-24 10:56
Incorporating Information from Completed Trials in Future Trial Planning,ities under some definitions of success. We can use simulations to estimate these probabilities when close-form expressions do not exist. With the use of prior distributions for the parameters of interest, we show how to assess the positive and negative predictive values of a design with its companion decision rule.作者: 勉勵(lì) 時(shí)間: 2025-3-24 15:07 作者: 磨坊 時(shí)間: 2025-3-24 22:21
Designing Phase 4 Trials,o consider a trial comparing a drug against a comparator using information obtained from the network meta-analysis. We also discuss how prior distributions for treatment effects may be obtained by other means such as PK/PD modeling.作者: Countermand 時(shí)間: 2025-3-25 01:42 作者: beta-cells 時(shí)間: 2025-3-25 04:43
Clinical Testing of a New Drug,development plan and new regulatory approval pathways. We offer some examples of recent advancements in clinical trial designs and conclude the chapter with a short summary of the salient points covered in the chapter.作者: 兇殘 時(shí)間: 2025-3-25 08:21 作者: PHON 時(shí)間: 2025-3-25 14:13 作者: jumble 時(shí)間: 2025-3-25 18:39 作者: Spirometry 時(shí)間: 2025-3-25 23:28 作者: MOT 時(shí)間: 2025-3-26 00:22 作者: esculent 時(shí)間: 2025-3-26 07:10
A Frequentist Decision-Making Framework,ons under the Frequentist approach are calibrated by how they would perform when they are used repeatedly. In the context of drug development, the two actions correspond to progressing or not progressing a drug for further development. These two actions are fundamental to decision-making in drug development.作者: 引起 時(shí)間: 2025-3-26 09:33
Characteristics of a Diagnostic Test,ew the metrics commonly used to characterize the performance of a diagnostic test. We then discuss what it means when a diagnostic test returns a positive or a negative result. We illustrate the discussions with the use of several decision rules.作者: 文字 時(shí)間: 2025-3-26 15:54
Book 20171st editionical industry who have a basic understanding of the drug-development processand the clinical trials conducted to support drug-marketing authorization.. .The authors provide software codes for select?analytical approaches discussed in the book. The book includes enough technical details to allow stat作者: 冷淡一切 時(shí)間: 2025-3-26 18:37 作者: 有危險(xiǎn) 時(shí)間: 2025-3-26 21:27
Christy Chuang-Stein,Simon Kirbyimulationexperience a success. There are numerous books on the market that deal with mathematical details of di?erent numerical methods for the calculation of electromagnetic ?elds. For engineers who want to kn978-3-642-06680-1978-3-540-28615-8Series ISSN 1860-4862 Series E-ISSN 1860-4870 作者: contradict 時(shí)間: 2025-3-27 03:39
Christy Chuang-Stein,Simon Kirbyimulationexperience a success. There are numerous books on the market that deal with mathematical details of di?erent numerical methods for the calculation of electromagnetic ?elds. For engineers who want to kn978-3-642-06680-1978-3-540-28615-8Series ISSN 1860-4862 Series E-ISSN 1860-4870 作者: 哎呦 時(shí)間: 2025-3-27 07:16
2366-8695 al trials conducted to support drug-marketing authorization.. .The authors provide software codes for select?analytical approaches discussed in the book. The book includes enough technical details to allow stat978-3-319-83434-4978-3-319-46076-5Series ISSN 2366-8695 Series E-ISSN 2366-8709 作者: 摻假 時(shí)間: 2025-3-27 11:55
d both groups need a practical introduction tocommercialEMmodelingsoftwaretomaketheir?rstsimulationexperience a success. There are numerous books on the market that deal with mathematical details of di?erent numerical methods for the calculation of electromagnetic ?elds. For engineers who want to kn作者: GLARE 時(shí)間: 2025-3-27 16:30
Christy Chuang-Stein,Simon Kirbyd both groups need a practical introduction tocommercialEMmodelingsoftwaretomaketheir?rstsimulationexperience a success. There are numerous books on the market that deal with mathematical details of di?erent numerical methods for the calculation of electromagnetic ?elds. For engineers who want to kn作者: 沉著 時(shí)間: 2025-3-27 20:51
Christy Chuang-Stein,Simon Kirbyd both groups need a practical introduction tocommercialEMmodelingsoftwaretomaketheir?rstsimulationexperience a success. There are numerous books on the market that deal with mathematical details of di?erent numerical methods for the calculation of electromagnetic ?elds. For engineers who want to kn作者: 笨拙的你 時(shí)間: 2025-3-27 22:17
Christy Chuang-Stein,Simon Kirbyd both groups need a practical introduction tocommercialEMmodelingsoftwaretomaketheir?rstsimulationexperience a success. There are numerous books on the market that deal with mathematical details of di?erent numerical methods for the calculation of electromagnetic ?elds. For engineers who want to kn作者: 墻壁 時(shí)間: 2025-3-28 02:24 作者: 一瞥 時(shí)間: 2025-3-28 07:46
Christy Chuang-Stein,Simon Kirbyd both groups need a practical introduction tocommercialEMmodelingsoftwaretomaketheir?rstsimulationexperience a success. There are numerous books on the market that deal with mathematical details of di?erent numerical methods for the calculation of electromagnetic ?elds. For engineers who want to kn作者: Left-Atrium 時(shí)間: 2025-3-28 13:18
Christy Chuang-Stein,Simon Kirbyn, and (iii) magnetostriction mechanism by the piezomagnetic effect. The Lorentz-force mechanism arises in all conducting materials, while other two appear only in ferromagnetic materials. For nonmagnetic metals, therefore, the Lorentz-force mechanism explains exactly the transfer with an EMAT (Gaer作者: compel 時(shí)間: 2025-3-28 15:02
Christy Chuang-Stein,Simon Kirbygives the case thickness in an A-scope display. It, however, requires the parts to be immersed in a water tank for acoustic coupling, making on-line inspection inapplicable. Another shortcoming is that the dominant front echo masks the signal from a shallow interface and this technique fails for a t作者: Inelasticity 時(shí)間: 2025-3-28 21:56
Christy Chuang-Stein,Simon Kirbyundaries in natural rocks, for instance. The opposite faces are in contact with each other but not well tightly. They open, close, or grind responding to the applied stress and acoustic fields. This rectifying effect can distort the waveform causing the nonlinearity.作者: cloture 時(shí)間: 2025-3-28 23:33
undaries in natural rocks, for instance. The opposite faces are in contact with each other but not well tightly. They open, close, or grind responding to the applied stress and acoustic fields. This rectifying effect can distort the waveform causing the nonlinearity.作者: Generator 時(shí)間: 2025-3-29 06:11
t are used to calculate approximate solutions of Maxwell’s equations have evolved from pure academic disciplines to powerful and user-friendly - gineering software tools. Meanwhile numerous commercial software packages exist that are widely used in the RF engineering community. Developments in theso作者: tattle 時(shí)間: 2025-3-29 07:54 作者: 秘方藥 時(shí)間: 2025-3-29 13:41
Christy Chuang-Stein,Simon Kirbyt are used to calculate approximate solutions of Maxwell’s equations have evolved from pure academic disciplines to powerful and user-friendly - gineering software tools. Meanwhile numerous commercial software packages exist that are widely used in the RF engineering community. Developments in theso作者: endoscopy 時(shí)間: 2025-3-29 15:58 作者: Preamble 時(shí)間: 2025-3-29 21:19
Christy Chuang-Stein,Simon Kirbylistic view on the capabilities and limits of up-to-date 3D Thisbookaddressesnumericalfull-wavemethodsfortheanalysisanddesignof antennas and microwave structures. In the last decades these numerical me- ods that are used to calculate approximate solutions of Maxwell’s equations have evolved from pur作者: Mortal 時(shí)間: 2025-3-30 02:44 作者: 使增至最大 時(shí)間: 2025-3-30 04:28 作者: 紳士 時(shí)間: 2025-3-30 11:57
Christy Chuang-Stein,Simon Kirbyt are used to calculate approximate solutions of Maxwell’s equations have evolved from pure academic disciplines to powerful and user-friendly - gineering software tools. Meanwhile numerous commercial software packages exist that are widely used in the RF engineering community. Developments in theso作者: Infant 時(shí)間: 2025-3-30 15:47
